Rentabilidad de la baciloscopia y el cultivo en muestras de jugo gástrico para el diagnóstico de la tuberculosis

Durán, D. Gómez-Pastrana; Santiago, R. Torronteras; Mateo, P. Caro; López-Barrio, A.M.; Mardones, Patricia; Martín, Arturo Sousa; Mantecon, Matthieu; González, J.

doi:10.1016/s1695-4033(00)78620-6

Cited by 10 publications

(5 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nonetheless, in a child with a high pre-test probability of having pulmonary TB, a positive result has a high predictive value, and studies using culture as a reference standard report a very high specificity (~95%) [61–63]. Microscopy’s low sensitivity and inability to differentiate between AFB species (especially relevant for gastric aspirate specimens), means it should not be used as a sole mycobacterial test for detecting M. tuberculosis .…”

Section: Mycobacterial Detectionmentioning

confidence: 99%

Tuberculosis exposure, infection and disease in children: a systematic diagnostic approach

Roya-Pabón

Pérez-Vélez

2016

Pneumonia

View full text Add to dashboard Cite

The accurate diagnosis of tuberculosis (TB) in children remains challenging. A myriad of common childhood diseases can present with similar symptoms and signs, and differentiating between exposure and infection, as well as infection and disease can be problematic. The paucibacillary nature of childhood TB complicates bacteriological confirmation and specimen collection is difficult. In most instances intrathoracic TB remains a clinical diagnosis. TB infection and disease represent a dynamic continuum from TB exposure with/without infection, to subclinical/incipient disease, to non-severe and severe disease. The clinical spectrum of intrathoracic TB in children is broad, and the classification of clinical, radiological, endoscopic, and laboratory findings into recognized clinical syndromes allows a more refined diagnostic approach in order to minimize both under- and over-diagnosis. Bacteriological confirmation can be improved significantly by collecting multiple, high-quality specimens from the most appropriate source. Mycobacterial testing should include traditional smear microscopy and culture, as well as nucleic acid amplification testing. A systematic approach to the child with recent exposure to TB, or with clinical and radiological findings compatible with this diagnosis, should allow pragmatic classification as TB exposure, infection, or disease to facilitate timely and appropriate management. It is important to also assess risk factors for TB disease progression and to undertake follow-up evaluations to monitor treatment response and ongoing evidence supporting a TB, or alternative, diagnosis.Electronic supplementary materialThe online version of this article (doi:10.1186/s41479-016-0023-9) contains supplementary material, which is available to authorized users.

show abstract

Section: Mycobacterial Detectionmentioning

confidence: 99%

Tuberculosis exposure, infection and disease in children: a systematic diagnostic approach

Roya-Pabón

Pérez-Vélez

2016

Pneumonia

View full text Add to dashboard Cite

show abstract

“…Induced sputum or nasopharyngeal aspirated samples can be a valid alternative, particularly in out-patient children, although the sensitivity is similar to that of gastric juice 19,20 . Direct staining of the samples obtained provides a rapid probable diagnosis that enables specific treatment to be started, however, its sensitivity (< 15 %) is significantly less than that of the culture 17,21 . Nucleic acid amplification techniques such as polymerase chain reaction (PCR), can provide rapid results within 1-2 days and increases the sensitivity to 60 % 22 .…”

Section: Diagnosis Of Tuberculosis Diseasementioning

confidence: 99%

Should pulmonary computed tomography be performed in children with tuberculosis infection without apparent disease?

Gómez‐Pastrana¹,

Carceller-Blanchard²

2007

An Pediatr (Barc)

View full text Add to dashboard Cite

Background During early childhood, in particular, there is a continuum between tuberculosis infection and disease. When establishing the diagnosis in a child with suspected tuberculosis, the distinction between infection and disease frequently depends on the interpretation of the chest X-ray. Some studies have shown hilar and mediastinal lymphadenopathies on computed tomography (CT) in children with tuberculosis infection without apparent disease, i.e., asymptomatic children with a positive tuberculin skin test and normal chest X-ray. These observations raise the issue of whether pulmonary CT should be performed in children with tuberculosis infection without apparent disease and whether different types of therapy should be administered depending on the results. Methods We reviewed the physiopathology of tuberculosis infection and disease, diagnostic methods and treatment, and the literature on the use of pulmonary CT scan in pediatric tuberculosis. Results Modern CT scanners indicate hilar and mediastinal lymphadenopathies in many of the children with tuberculosis infection with no apparent disease on chest X-rays. However, neither the size nor the morphology of these adenopathies allows active tuberculosis to be diagnosed. The natural history of childhood tuberculosis indicates that most children show hilar lymphadenopathies after the primary infection, although progression to disease is rare and is characterized by the presence of clinical symptoms. The exceptions are children younger than 4 years old and those with immune alterations who more frequently show progression of infection to disease and who require close follow-up. In addition, the experience accumulated over many years in the treatment of tuberculosis infection with isoniazid has shown this drug to be effective in both short-and long-term prevention of active disease. Official guidelines and expert opinion do not recommend systematic pulmonary CT scan in these children or modification of treatment according to the results. Conclusions Hilar and mediastinal lymph nodes are frequently found in the CT scans of children with tuberculosis infection without apparent disease but there is no evidence that these adenopathies indicate active disease or that these children require different treatment. Consequently, until demonstrated otherwise, pulmonary CT scanning and changes in chemoprophylaxis are not justified in children with tuberculosis infection.

show abstract

“…En niños infectados la sensibilidad del examen directo del jugo gástrico suele ser inferior al 10% y la especificidad es controvertida (en algunos estudios hasta el 96%), pudiendo existir falsos positivos; éstos se han atribuido a saprofitos ácido alcohol resistentes presentes en el jugo gástrico, por lo que el resultado de las baciloscopias debe ser confirmada con el cultivo. La rentabilidad del cultivo del jugo gástrico en tres muestras consecutivas es del 20-40%, pero en lactantes puede llegar al 70% 20 . Aumenta cuanto mayor es la afectación parenquimatosa del paciente, en niños menores de 2 años, pacientes con TB mayor de 17 mm o cuando la fuente de contagio es un conviviente.…”

Section: Diagnósticounclassified

“…Aumenta cuanto mayor es la afectación parenquimatosa del paciente, en niños menores de 2 años, pacientes con TB mayor de 17 mm o cuando la fuente de contagio es un conviviente. Las muestras obtenidas por lavado broncoalveolar en niños no parecen tener mayor rentabilidad que los jugos gástricos seriados 20 . La utilidad de la PCR en el estudio de la tuberculosis en niños no ha sido tan contrastada como en los adultos.…”

Section: Diagnósticounclassified

Características de la enfermedad tuberculosa en la infancia

Herranz

Bernaola

2007

Anales Sis San Navarra

View full text Add to dashboard Cite

RESUMENLa tuberculosis es un problema grave de salud mundial, con un incremento de los casos en los últimos años. Los niños son más vulnerables a la infección, con mayor riesgo de progresión a enfermedad y mayor frecuencia de formas graves de la misma. A pesar de ello es excepcional que sean bacilíferos, no teniendo su tratamiento un gran papel en el control epidemiológico de la enfermedad. Sin embargo, el tratamiento de la infección tuberculosa latente en los niños evita su progresión a enfermedad y el estudio familiar de contactos puede permitir el diagnóstico, tratamiento y control del adulto contagioso.En este trabajo se repasa la tuberculosis en la infancia, haciendo énfasis en algunas de sus peculiaridades. Se analizan la infección y la enfermedad tuberculosa, la conducta ante el hijo de madre con infección o enfermedad tuberculosa y aspectos de la prevención por medio de la quimio e inmunoprofilaxis.Palabras clave. Tuberculosis. Infancia. Neonatal. Vacuna BCG. Tuberculina.

show abstract

Rentabilidad de la baciloscopia y el cultivo en muestras de jugo gástrico para el diagnóstico de la tuberculosis

Cited by 10 publications

References 35 publications

Tuberculosis exposure, infection and disease in children: a systematic diagnostic approach

Tuberculosis exposure, infection and disease in children: a systematic diagnostic approach

Should pulmonary computed tomography be performed in children with tuberculosis infection without apparent disease?

Características de la enfermedad tuberculosa en la infancia

Contact Info

Product

Resources

About