Reoccurrence of Suspected Human-to-Turkey Transmission of H1N1 Pandemic 2009 Virus in Turkey Breeder Flocks in Ontario and Manitoba, 2016

Berhane, Yohannes; Ojkić, Davor; Pople, Neil; Lung, Oliver; Pasick, John

doi:10.1111/tbed.12566

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…Since it first emerged in Mexico in the early 2009, 1 H1N1 viral infections have been recorded in most areas of the world 2, 3, 4 and are an important cause of severe acute pneumonia, which often results in acute respiratory distress syndrome (ARDS), a syndrome with a high risk of mortality. 5, 6, 7 Therefore, H1N1 infection represents a severe challenge and a significant threat to public health.…”

Section: Introductionmentioning

confidence: 99%

Nuclear translocation of HIF-1α induced by influenza A (H1N1) infection is critical to the production of proinflammatory cytokines

Guo

Zhu

Zhang

et al. 2017

Emerging Microbes & Infections

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Infection with the influenza A (H1N1) virus is a major challenge for public health because it can cause severe morbidity and even mortality in humans. The over-secretion of inflammatory cytokines (cytokine storm) is considered to be a key contributor to the severe pneumonia caused by H1N1 infection. It has been reported that hypoxia-inducible factor 1-alpha (HIF-1α) is associated with the production of proinflammatory molecules, but whether HIF-1α participates in the acute inflammatory responses against H1N1 infection is still unclear. To investigate the role of HIF-1α in H1N1 infection, the expression and nuclear translocation of HIF-1α in A549 and THP-1 cell lines infected with H1N1 virus were observed. The results showed that without altering the intracellular mRNA or protein expression of HIF-1α, H1N1 infection only induced nuclear translocation of HIF-1α under normal oxygen concentrations. The use of 2-methoxyestradiol (2ME2), a HIF-1α inhibitor that blocks HIF-1α nuclear accumulation, in H1N1-infected cells decreased the mRNA and protein expression of tumor necrosis factor-alpha (TNF-α) and interleukin (IL)-6 and increased the levels of IL-10. In contrast, H1N1-infected cells under hypoxic conditions had increased HIF-1α nuclear accumulation, increased expression of TNF-α and IL-6 and decreased levels of IL-10. In conclusion, our data implied that in vitro H1N1 infection induced nuclear translocation of HIF-1α without altering the expression of HIF-1α, which may promote the secretion of proinflammatory cytokines during H1N1 infection.

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Section: Introductionmentioning

confidence: 99%

Nuclear translocation of HIF-1α induced by influenza A (H1N1) infection is critical to the production of proinflammatory cytokines

Guo

Zhu

Zhang

et al. 2017

Emerging Microbes & Infections

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“…Of note, several AIVs, including H5, H7, and H9 viruses, have been reported in pigs [51]. Transmission of swIAV to poultry, mainly turkeys, has also been reported [170][171][172].…”

Section: Zoonotic Swine Influenza a Virus (Swiav)mentioning

confidence: 99%

Zoonotic Animal Influenza Virus and Potential Mixing Vessel Hosts

Abdelwhab

Mettenleiter

2023

Viruses

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Influenza viruses belong to the family Orthomyxoviridae with a negative-sense, single-stranded segmented RNA genome. They infect a wide range of animals, including humans. From 1918 to 2009, there were four influenza pandemics, which caused millions of casualties. Frequent spillover of animal influenza viruses to humans with or without intermediate hosts poses a serious zoonotic and pandemic threat. The current SARS-CoV-2 pandemic overshadowed the high risk raised by animal influenza viruses, but highlighted the role of wildlife as a reservoir for pandemic viruses. In this review, we summarize the occurrence of animal influenza virus in humans and describe potential mixing vessel or intermediate hosts for zoonotic influenza viruses. While several animal influenza viruses possess a high zoonotic risk (e.g., avian and swine influenza viruses), others are of low to negligible zoonotic potential (e.g., equine, canine, bat and bovine influenza viruses). Transmission can occur directly from animals, particularly poultry and swine, to humans or through reassortant viruses in “mixing vessel” hosts. To date, there are less than 3000 confirmed human infections with avian-origin viruses and less than 7000 subclinical infections documented. Likewise, only a few hundreds of confirmed human cases caused by swine influenza viruses have been reported. Pigs are the historic mixing vessel host for the generation of zoonotic influenza viruses due to the expression of both avian-type and human-type receptors. Nevertheless, there are a number of hosts which carry both types of receptors and can act as a potential mixing vessel host. High vigilance is warranted to prevent the next pandemic caused by animal influenza viruses.

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Risk of Swine influenza for veterinary medicine and human health in Ukraine

Stegniy,

Rula,

Muzyka

et al. 2023

J. Vet. Med. Biotechnol. Biosafety

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The article provides a brief review of the literature on influenza viruses, including their prevalence, classification, pathogenicity, ability to mutate and reassort, and some peculiarities of their biological properties. Special attention is given to swine influenza, since interspecies transmission of influenza viruses between pigs and humans can have serious consequences for both human and veterinary medicine. The results of pilot studies conducted at the NSC ‘IECVM’ prove the circulation of influenza A viruses among pigs in Ukraine — 324 samples of blood sera from pigs of different age groups from different regions of Ukraine were tested using an ELISA test system, 48 (14.8%) positive samples were found. Seroprevalence reached 100% in some farms and antibodies were detected in animals aged 24–73 days. The prospect of further work is to conduct surveillance studies (serological, molecular biological, virological) of pigs in both large breeding complexes and private households to detect antibodies to influenza A and, based on the results obtained, to draw conclusions about the circulation of influenza A viruses in Ukraine

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Reoccurrence of Suspected Human-to-Turkey Transmission of H1N1 Pandemic 2009 Virus in Turkey Breeder Flocks in Ontario and Manitoba, 2016

Cited by 3 publications

References 22 publications

Nuclear translocation of HIF-1α induced by influenza A (H1N1) infection is critical to the production of proinflammatory cytokines

Nuclear translocation of HIF-1α induced by influenza A (H1N1) infection is critical to the production of proinflammatory cytokines

Zoonotic Animal Influenza Virus and Potential Mixing Vessel Hosts

Risk of Swine influenza for veterinary medicine and human health in Ukraine

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