Reoperations in patients with venous leg ulcers

Saleem, Taimur

doi:10.1016/j.jvsv.2022.08.014

Cited by 1 publication

(2 citation statements)

References 6 publications

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“…The resulting venous stasis, which is marked by the development of oedema and an increase in tissue pressure, is a significant factor in the development of venous ulcers, regardless of the cause 23 . A sequence of pathogenic events that affect cells are set off by prolonged venous hypertension, which eventually results in skin disintegration and ulceration as well as clinical signs and symptoms of cardiovascular disease 24 . Overall, the relationship between DVT and VLUs is well established.…”

Section: Discussionmentioning

confidence: 99%

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Association between stroke and venous leg ulcers: A Mendelian randomization study

Xie,

Han,

Liu

et al. 2024

International Wound Journal

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To investigate any potential bidirectional causal relationships between stroke and venous leg ulcers (VLUs), Mendelian randomization (MR) analyses were carried out in this study. The exposure factor was stroke, the outcome factor was VLUs. The two‐sample MR study was carried out based on the online analysis platform (http://app.mrbase.org/). The association of stroke and VLUs was analysed via methods of Inverse Variance Weighted (IVW), Weighted Median, MR‐Egger and weighted mode. IVW method suggested no association between stroke and VLUs ((β 1.06; SE 9.321; p = 0.9095)). Weighted median estimator (β 5.906; SE 11.99, p = 0.6223), MR‐Egger (β −0.8677; SE 21.89; p = 0.9691) and weighted mode (β 9.336; SE 17.77; p = 0.6089) showed consistent results. Conversely, evidence indicating that the presence of VLUs increased the risk of stroke was lacking. According to this MR study, there is no causal connection between stroke and VLUs, which suggests that therapies targeting stroke may not be effective against VLUs.

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Section: Discussionmentioning

confidence: 99%

“… 23 A sequence of pathogenic events that affect cells are set off by prolonged venous hypertension, which eventually results in skin disintegration and ulceration as well as clinical signs and symptoms of cardiovascular disease. 24 Overall, the relationship between DVT and VLUs is well established.…”

Section: Discussionmentioning

confidence: 99%