Reorganized Hubs of Brain Functional Networks after Acute Mild Traumatic Brain Injury

Bai, Lijun; Yin, Bo; Lei, Shuoyan; Li, Tianhui; Wang, Shan; Pan, Yizhen; Gan, Shuoqiu; Jia, Xiaoyan; Li, Xuan; Xiong, Feng; Yan, Zhihan; Bai, Guanghui

doi:10.1089/neu.2021.0450

Cited by 6 publications

(9 citation statements)

References 91 publications

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“…Specifically, increased DMN hub and non-hub connectivity was associated with increased cognitive and somatic symptoms after a concussion. While these results are consistent with prior work 23 , we did not find evidence of a relationship with affective symptoms that has been demonstrated (based on depression-related symptoms) in other work 25 . Our findings of functional connectivity between DMN hubs and non-hubs and the relationship to symptomology help expand the understanding of the pathophysiology of clustered symptoms after concussion.…”

Section: Discussionsupporting

confidence: 87%

“…Similar findings have been identified when comparing moderate TBI participants to healthy participants 62 . In addition, another study focused on a hub within the visual network and found functional connectivity was specifically associated with sensitivity to light and noise in a concussed population 23 . Similarly, we also identified a stronger relationship with somatic symptoms, which encompasses light and noise sensitivity, and functional connectivity between DMN and visual network at post-injury.…”

Section: Between Dmn Functional Connectivitymentioning

confidence: 99%

“…These more specific changes may primarily impact connectivity to regions that are critical in promoting network efficiency across the brain, such as hubs 49 . Prior research has identified disruption to hubs across the brain in a concussed population [22][23][24][25] , but there is lack of consensus in the location of changes. Some studies found that a concussed population had on average a different set of brain regions identified as hubs compared to a non-concussed group and that this set of hubs differed throughout a 6-month recovery period 23,24 .…”

Section: Within Dmn Functional Connectivitymentioning

confidence: 99%

“…Prior research has identified disruption to hubs across the brain in a concussed population [22][23][24][25] , but there is lack of consensus in the location of changes. Some studies found that a concussed population had on average a different set of brain regions identified as hubs compared to a non-concussed group and that this set of hubs differed throughout a 6-month recovery period 23,24 . Similarly, we identified that connectivity involving DMN hubs is disrupted after concussion and during recovery.…”

Section: Within Dmn Functional Connectivitymentioning

confidence: 99%

“…Therefore, when hubs are disrupted through pathological processes, there is a disproportionate decrease in network efficiency compared to disruption of non-hubs. For example, lesions to regions identified as hubs can lead to long-term cognitive deficits 16, , and more subtle injuries, such as a concussion, may also result in a disruption to hubs [22][23][24][25] . However, this research on concussions (typically classified as mild TBIs) is limited and only includes imaging data collected post-injury.…”

Section: Introductionmentioning

confidence: 99%

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Concussion-related disruptions to hub connectivity in the default mode network are related to symptoms and cognition

Bouchard

Higgins

Amadon

et al. 2023

Preprint

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Concussions present with a myriad of symptomatic and cognitive concerns; however, the relationship between these functional disruptions and the underlying changes in the brain are not yet well understood. Hubs, or brain regions that are connected to many different functional networks, may be specifically disrupted after concussion. Given the implications in concussion research, we quantified hub disruption within the default mode network (DMN) and between the DMN and other brain networks. We collected resting-state functional magnetic resonance imaging data from collegiate student-athletes (n = 44) at three timepoints: baseline (prior to beginning their athletic season), acute post-injury (approximately 48 hours after a diagnosed concussion), and recovery (after starting return-to-play progression, but prior to returning to contact). To link these connectivity changes to clinical outcomes, self-reported symptoms and computerized cognitive assessments were collected across similar timepoints. Functional connectivity between regions within in the DMN increased from baseline to post-injury and decreased from post-injury to recovery. The relationship between functional connectivity and symptoms was stronger post-injury than at baseline and recovery. Similarly, the relationship between functional connectivity in the DMN and visual memory performance was stronger post-injury than at baseline and recovery. In addition, functional connectivity between DMN hubs and visual network non-hubs decreased from baseline to post-injury and increased from post-injury to recovery. The relationship between somatic symptoms and functional connectivity between DMN hubs and visual network non-hubs was also stronger post-injury. The relationship between visual memory performance and functional connectivity between DMN hubs and visual network non-hubs was also stronger post-injury. These results highlight a unique relationship between self-reported symptoms, visual memory performance and acute functional connectivity changes involving DMN hubs after concussion in athletes. This may provide evidence for a disrupted balance of within- and between-network communication highlighting possible network inefficiencies after concussion. These results aid in our understanding of the pathophysiological disruptions after concussion and inform our understanding of the associations between disruptions in brain connectivity and specific clinical presentations acutely post-injury.

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Section: Discussionsupporting

confidence: 87%

Section: Between Dmn Functional Connectivitymentioning

confidence: 99%

Section: Within Dmn Functional Connectivitymentioning

confidence: 99%

Section: Within Dmn Functional Connectivitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Concussion-related disruptions to hub connectivity in the default mode network are related to symptoms and cognition

Bouchard

Higgins

Amadon

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Concussion-Related Disruptions to Hub Connectivity in the Default Mode Network Are Related to Symptoms and Cognition

Bouchard,

Higgins,

Amadon

et al. 2024

Journal of Neurotrauma

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Disrupted network communication predicts mild cognitive impairment in end-stage renal disease: an individualized machine learning study based on resting-state fMRI

Yu,

Pang,

Liu

et al. 2023

Cerebral Cortex

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End-Stage Renal Disease (ESRD) is known to be associated with a range of brain injuries, including cognitive decline. The purpose of this study is to investigate the functional connectivity (FC) of the resting-state networks (RSNs) through resting state functional magnetic resonance imaging (MRI), in order to gain insight into the neuropathological mechanism of ESRD. A total of 48 ESRD patients and 49 healthy controls underwent resting-state functional MRI and neuropsychological tests, for which Independent Components Analysis and graph-theory (GT) analysis were utilized. With the machine learning results, we examined the connections between RSNs abnormalities and neuropsychological test scores. Combining intra/inter network FC differences and GT results, ESRD was optimally distinguished in the testing dataset, with a balanced accuracy of 0.917 and area under curve (AUC) of 0.942. Shapley additive explanations results revealed that the increased functional network connectivity between DMN and left frontoparietal network (LFPN) was the most critical predictor for ESRD associated mild cognitive impairment diagnosis. Moreover, hypoSN (salience network) was positively correlated with Attention scores, while hyperLFPN was negatively correlated with Execution scores, indicating correlations between functional disruption and cognitive impairment measurements in ESRD patients. This study demonstrated that both the loss of FC within the SN and compensatory FC within the lateral frontoparietal network coexist in ESRD. This provides a network basis for understanding the individual brain circuits and offers additional noninvasive evidence to comprehend the brain networks in ESRD.

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Reorganized Hubs of Brain Functional Networks after Acute Mild Traumatic Brain Injury

Cited by 6 publications

References 91 publications

Concussion-related disruptions to hub connectivity in the default mode network are related to symptoms and cognition

Concussion-related disruptions to hub connectivity in the default mode network are related to symptoms and cognition

Concussion-Related Disruptions to Hub Connectivity in the Default Mode Network Are Related to Symptoms and Cognition

Disrupted network communication predicts mild cognitive impairment in end-stage renal disease: an individualized machine learning study based on resting-state fMRI

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