Cardiovascular diseases include coronary artery, cerebrovascular, renovascular, and peripheral vascular diseases. These vascular diseases are known to present with many serious conditions―which include angina and acute coronary syndromes, strokes, cognitive impairment and dementia, epilepsy, parkinsonism, claudication, erectile dysfunction, renal failure, and hypertension. The underlying pathology for these ailments is atherosclerosis. Since 1950s, we have become increasingly focused on causation and management of cardiovascular diseases, which have strong behavioral components. Primary and secondary prevention remains our long-term goal. This paper discusses a new perspective on targeting cardiovascular diseases through reorientation of activities.