2023
DOI: 10.3390/ijms242115783
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Repaglinide Induces ATF6 Processing and Neuroprotection in Transgenic SOD1G93A Mice

Rafael Gonzalo-Gobernado,
Laura Moreno-Martínez,
Paz González
et al.

Abstract: The interaction of the activating transcription factor 6 (ATF6), a key effector of the unfolded protein response (UPR) in the endoplasmic reticulum, with the neuronal calcium sensor Downstream Regulatory Element Antagonist Modulator (DREAM) is a potential therapeutic target in neurodegeneration. Modulation of the ATF6–DREAM interaction with repaglinide (RP) induced neuroprotection in a model of Huntington’s disease. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no cure, characterized… Show more

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