In the absence of universally accepted staging systems, the assessment of both basal and squamous cell carcinomas presents a formidable challenge. The NCCN Guidelines, which reflect the most up-to-date, evidence-based data relating to the evaluation and management of these nonmelanoma neoplasms, provide criteria for their risk stratification. Moreover, the current treatment algorithms discussed to aid in risk category–based clinical decision-making. Case reports demonstrate the practical application of the NCCN Guidelines and highlight the importance of a multidisciplinary approach.