Repair of Cloacal Exstrophy, Omphalocele, and Gastroschisis Using Porcine Small-Intestinal Submucosa or Cadaveric Skin Homograft

Management of complicated gastroschisis with porcine small intestinal submucosa and negative pressure wound therapy

“…All reports of fascial reconstruction with SIS have included only cases in which there was adequate skin for coverage [6,11]. Our patients lacked adequate skin for closure after fascial reconstruction with SIS; therefore, NPWT was used, which has been accepted since 1995 as an adjunct to the management of complex wounds in adults.…”

“…In addition, SIS grafts in animals have been shown to have a lower incidence of infection than PTFE [10]. Small intestinal submucosa can be used as either an inlay or an onlay graft to repair abdominal wall fascial defects in contaminated or infected fields [6,[11][12][13].…”

Small Intestinal Submucosa (Surgisis) as a Bioactive Prosthetic Material for Repair of Abdominal Wall Fascial Defect

“…Surgisis, as either an onlay or an inlay graft, for the repair of abdominal wall fascial defects was recently described in the plastic surgery literature in a case report, with good success. 13,14 SUMMARY There are adequate experimental data to support the efficacy of Surgisis as a bioactive prosthetic material for the repair of abdominal wall fascial defects, because it is a naturally occurring extracellular matrix that is easily absorbed, supports early and abundant new vessel growth, and serves as a scaffold for the constructive remodeling of fascial and related tissues. Clinically, Surgisis, as a mesh graft material of choice for the repair of abdominal wall or inguinal hernias in contaminated or infected sites and in the pediatric population, showed no chronic infection or hernia recurrence during a relatively short-term follow-up.…”

Fetal Abdominal Wall Repair with a Collagen Biomatrix in an Experimental Sheep Model for Gastroschisis

“…In these studies, full-or partial-thickness abdominal wall defects were surgically created, and scaffolds of extra cellular matrix were used to close these defects, resulting in firm connective tissue formation, degradation of the scaffold, and some reported regeneration of skeletal muscle.14,20-25 Acellular scaffolds have also been used experimentally in small numbers of hum ans w ith large abdominal wall defects that were inappropriate for prim ary closure. 26,27 In previous work, we used a collagen biomatrix to cover a surgically created neural tube defect in fetal lambs. 28,29 In the present study, we used the fetal lamb model for surgical creation of gastroschisis.…”