Tetralogy of fallot (TOF) is a cyanotic congenital heart disease (CHD) characterized by aortic over riding, right ventricular outflow tract (RVOT) obstruction, pulmonary stenosis, and ventricular septal defect (VSD). We report a case of a neonate with TOF and anorectal malformation posted for a transverse colostomy. During this procedure, our objectives were to prevent cyanotic spells, balance pulmonary vascular resistance, and systemic vascular resistance.