Repair of Pulmonary Artery Aneurysms

Tuncer, Altug; Tuncer, Eylem; Taş, Serpil; Erdem, Hasan; Polat, Adil

doi:10.1111/j.1540-8191.2011.01302.x

Cited by 8 publications

(9 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study established 2.9 cm in men and 2.7 cm in women as sex-specific normative reference values for MPA-d and 0.9 for MPA-r [ 14 ]. Aneurysms of MPA are defined with MPA-d >4 cm [ 20 , 21 ]. Such aneurysms are reported in 1 of 14,000 autopsies [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

“…Such aneurysms are reported in 1 of 14,000 autopsies [ 22 ]. Criteria for surgery of MPA aneurysms are not firmly established, but surgeons agree to operate upon in most patients with symptomatic MPA aneurysms or in aneurysms with MPA-d >6 cm [ 20 , 21 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

“…MPA aneurysms usually occur in the setting of PH, and they have been reported in PH group 1 [ 29 ] including PH related to congenital heart disease [ 30 ], where patent ductus arteriosus is the most frequently reported underlying pathology of the MPA aneurysms [ 31 , 32 ], PH group 2, including acquired heart valve disease [ 20 ], and PH group 3 including chronic obstructive pulmonary disease (COPD) [ 33 ]. Some MPA aneurysms arise in the absence of PH, and they may have a more benign prognosis than high pressure MPA aneurysms [ 30 , 32 ].…”

Section: Introductionmentioning

confidence: 99%

“…Some MPA aneurysms arise in the absence of PH, and they may have a more benign prognosis than high pressure MPA aneurysms [ 30 , 32 ]. These low pressure MPA aneurysms may arise from pulmonary valve stenosis [ 20 , 34 ], vasculitis such as Behcet’s disease [ 35 ] or giant cell arteritis [ 36 ], infections such as tuberculosis [ 37 ], syphilis [ 38 , 39 ] and septic emboli [ 22 ], extravascular [ 40 ] or endovascular trauma [ 31 , 41 ], or degenerative diseases including atherosclerosis [ 42 ] and media degeneration [ 43 ]. Some “idiopathic” MPA aneurysms may form without any of these causes [ 20 , 23 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The main pulmonary artery in adults: a controlled multicenter study with assessment of echocardiographic reference values, and the frequency of dilatation and aneurysm in Marfan syndrome

Sheikhzadeh

Backer

Gorgan

et al. 2014

Orphanet J Rare Dis

View full text Add to dashboard Cite

BackgroundEchocardiographic upper normal limits of both main pulmonary artery (MPA) diameters (MPA-d) and ratio of MPA to aortic root diameter (MPA-r) are not defined in healthy adults. Accordingly, frequency of MPA dilatation based on echocardiography remains to be assessed in adults with Marfan syndrome (MFS).MethodsWe enrolled 123 normal adults (72 men, 52 women aged 42 ± 14 years) and 98 patients with MFS (42 men, 56 women aged 39 ± 14 years) in a retrospective cross-sectional observational controlled study in four tertiary care centers. We defined outcome measures including upper normal limits of MPA-d and MPA-r as 95 quantile of normal persons, MPA dilatation as diameters > upper normal limits, MPA aneurysm as diameters >4 cm, and indication for surgery as MPA diameters >6 cm.ResultsMPA diameters revealed normal distribution without correlation to age, sex, body weight, body height, body mass index and body surface area. The upper normal limit was 2.6 cm (95% confidence interval (CI) =2.44-2.76 cm) for MPA-d, and 1.05 (95% CI = .86–1.24) for MPA-r. MPA dilatation presented in 6 normal persons (4.9%) and in 68 MFS patients (69.4%; P < .001), MPA aneurysm presented only in MFS (15 patients; 15.3%; P < .001), and no patient required surgery. Mean MPA-r were increased in MFS (P < .001), but ratios >1.05 were equally frequent in 7 normal persons (5%) and in 8 MFS patients (10.5%; P = .161). MPA-r related to aortic root diameters (P = .042), reduced left ventricular ejection fraction (P = .006), and increased pulmonary artery systolic pressures (P = .040). No clinical manifestations of MFS and no FBN1 mutation characteristics related to MPA diameters.ConclusionsWe established 2.6 cm for MPA-d and 1.05 for MPA-r as upper normal limits. MFS exhibits a high prevalence of MPA dilatation and aneurysm. However, patients may require MPA surgery only in scarce circumstances, most likely because formation of marked MPA aneurysm may require LV dysfunction and increased PASP.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The main pulmonary artery in adults: a controlled multicenter study with assessment of echocardiographic reference values, and the frequency of dilatation and aneurysm in Marfan syndrome

Sheikhzadeh

Backer

Gorgan

et al. 2014

Orphanet J Rare Dis

View full text Add to dashboard Cite

show abstract

“…Due to the low number of reported cases in the literature, the best treatment for patients with PAD has not yet been defined. Only a few patients have been treated surgically and several surgical approaches have been used (Table ).…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Artery Dissection

Perrotta

Lentini

2015

J Card Surg

View full text Add to dashboard Cite

show abstract

The Pulmonary Artery in Pediatric Patients with Marfan Syndrome: An Underestimated Aspect of the Disease

et al. 2018

View full text Add to dashboard Cite

Aortic root dilatation and its complications are known to be the most important and life limiting features in patients with Marfan syndrome (MFS). Since monitoring of patients, preventive medical and surgical treatments are available nowadays, other MFS pathologies are becoming more relevant for the outcome of the disease. Main pulmonary artery (MPA) dilatation is a cardiac finding, which has not been fully investigated in children. Due to the similarities in tissue composition of the aortic and pulmonary root, MPA dilatation may cause complications and require treatment. In addition, it may be a predictor for severe connective tissue involvement. We retrospectively examined 135 pediatric patients with MFS. 8.1% showed MPA dilatation. MPA dilatation was associated with earlier occurrence of aortic dilatation, mitral valve prolapse, and systemic manifestations of MFS compared with patients without MPA dilatation (p < 0.05). The presence of MPA dilatation was also associated with a higher incidence of ectopia lentis (p < 0.05). Medical treatment was started earlier in MPA dilatation patients than in those without (p < 0.05). We conclude that MPA dilatation is a sign of more severe vascular and connective tissue involvement. Regular examination of the pulmonary artery is essential in MFS to avoid complications. As medical treatment of life threatening MFS events has improved, other features of MFS need to be investigated to improve quality of life.

show abstract

Repair of Pulmonary Artery Aneurysms

Abstract: Pulmonary artery aneurysms are rare entities which are usually associated with other congenital defects. While surgery is the preferred treatment for symptomatic aneurysms, controversy exists as to the indications for repair in asymptomatic patients.

Cited by 8 publications

References 14 publications

The main pulmonary artery in adults: a controlled multicenter study with assessment of echocardiographic reference values, and the frequency of dilatation and aneurysm in Marfan syndrome

The main pulmonary artery in adults: a controlled multicenter study with assessment of echocardiographic reference values, and the frequency of dilatation and aneurysm in Marfan syndrome

Pulmonary Artery Dissection

The Pulmonary Artery in Pediatric Patients with Marfan Syndrome: An Underestimated Aspect of the Disease

Contact Info

Product

Resources

About