Repair of the dura mater with processed collagen devices

Zerris, Vasilios A.; James, Kenneth S.; Roberts, Julie B.; Bell, Eugene; Heilman, Carl B.

doi:10.1002/jbm.b.30831

Cited by 107 publications

(79 citation statements)

References 22 publications

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“…To the best of our knowledge, previous animal studies [7, 8, 17, 19] did not investigate adhesions between semisynthetic collagen onlay grafts and lesioned cortex. Adhesions between graft and cortex are of significance in clinical use, since they might act as an epileptic focus.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast to previous animal studies for dural repair [1, 5, 7, 8, 10, 13–15, 17–19], in the present study, a dural defect and a cortical lesion were created to study the adhesion of devices to the dura, their subsequent tissue integration, and potential adhesion and scar formation with the underlying lesioned cortex. Properties of the dural substitutes regarding intraoperative handling and workability, initial watertightness of the dural reconstruction during surgery, biocompatabiliy, tissue integration and formation of adhesion to the intact or lesioned cortex were analysed at 1 and 6 months after the surgery.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of efficacy and biocompatibility of a novel semisynthetic collagen matrix as a dural onlay graft in a large animal model

et al. 2011

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BackgroundSemisynthetic collagen matrices are promising duraplasty grafts with low risk of cerebrospinal fluid (CSF) fistulas, good tissue integration and minor foreign body reaction. The present study investigates the efficacy and biocompatibility of a novel semisynthetic bilayered collagen matrix (BCM, B. Braun Aesculap) as dural onlay graft for duraplasty.MethodsThirty-four pigs underwent osteoclastic trepanation, excision of the dura, and placement of a cortical defect, followed by duraplasty using BCM, Suturable DuraGen™ (Integra Neuroscience), or periosteum. CSF tightness and intraoperative handling of the grafts were evaluated. Pigs were sacrificed after 1 and 6 months for histological analysis.FindingsBCM and DuraGen™ showed superior handling than periosteum with a trend for better adhesion to dura and CSF tightness for BCM. Periosteum, which was sutured unlike the synthetic grafts, had the highest intraoperative CSF tightness. Duraplasty time with periosteum was significantly higher (14.4 ± 2.7 min) compared with BCM (2.8 ± 0.8 min) or DuraGen™ (3.0 ± 0.5 min). Tissue integration by fibroblast infiltration was observed after 1 month for all devices. More adhesions between graft and cortex were observed with DuraGen™ compared with BCM and periosteum. No relevant adhesions between leptomeninges and BCM were observed and all devices showed comparable lymphocytic reaction of the brain. All devices were completely integrated after 6 months. BCM and DuraGen™ showed a trend for an enhanced lymphocytic reaction of the brain parenchyma compared with periosteum. Implant rejection was not observed.ConclusionSemisythetic collagen matrices are an attractive alternative in duraplasty due to their easy handling, lower surgical time, and high biocompatibility.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of efficacy and biocompatibility of a novel semisynthetic collagen matrix as a dural onlay graft in a large animal model

et al. 2011

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“…[8][9][10][11][12] However, the risk of disease transmission from allografts or animal-derived xenografts raises serious concerns. 2,5 Recent efforts have also been paid in bioresorbable synthetic polymer membranes as they are stronger, more suturable and lower in cost than collagen matrices. Poly(lactic acid) (PLA), polyglycolic acid (PGA) and poly("-caprolactone) (PCL) as well as copolymers of them are typical examples of FDA approved, semicrystalline polyesters that may degrade via hydrolysis of their ester linkages under physiological conditions with nontoxic degradation products.…”

Section: Introductionmentioning

confidence: 99%

Reconstructing spinal dura-like tissue using electrospun poly(lactide-co-glycolide) membranes and dermal fibroblasts to seamlessly repair spinal dural defects in goats

Li¹,

Yin²,

Liao

et al. 2015

J Biomater Appl

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Many neuro- and spinal surgeries involving access to the underlying nervous tissue will cause defect of spinal dural mater, further resulting in cerebrospinal fluid leakage. The current work was thus aimed to develop a package which included two layers of novel electrospun membranes, dermal fibroblasts and mussel adhesive protein for repairing spinal dural defect. The inner layer is electrospun fibrous poly(lactide-co-glycolide) membrane with oriented microstructure (O-poly(lactide-co-glycolide)), which was used as a substrate to anchor dermal fibroblasts as seed cells to reconstitute dura-like tissue via tissue engineering technique. The outer layer is chitosan-coated electrospun nonwoven poly(lactide-co-glycolide) membrane (poly(lactide-co-glycolide)-chitosan). During surgery, the inner reconstituted tissue layer was first used to directly cover dura defects, while the outer layer was placed onwards with its marginal area tightly immobilized to the surrounding normal spinal dura aided by mussel adhesive protein. Efficacy of the current design was verified in goats with spinal dural defects (0.6 cm × 0.5 cm) in lumbar. It was shown that seamless and quick sealing of the defect area with the implants was realized by mussel adhesive protein. Guided tissue growth and regeneration in the defects of goats were observed when they were repaired by the current package. Effective cerebrospinal fluid containment and anti-adhesion of the regenerated tissue to the surrounding tissue could be achieved in the current animal model. Hence, it could be ascertained that the current package could be a favorite choice for surgeries involving spinal dural defects.

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“…Moreover, gels placed in living tissues are remodeled over time by enzymes such as matrix metallo-proteases, enhancing the potential for integration of implants with surrounding tissue. Collagen is also used clinically in neurosurgery as a replacement for the outer meningeal membrane of the brain (Zerris et al, 2007) and has shown efficacy for the treatment of burns and slow healing skin wounds (Falanga & Sabolinski, 1999) and in reparation of damaged vocal cords (Luu et al, 2007; Kimura et al, 2010). …”

Section: Introductionmentioning

confidence: 99%

Self-Organizing Tissue-Engineered Constructs in Collagen Hydrogels

Gourdie¹,

Myers²,

McFadden

et al. 2012

Microsc Microanal

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A novel self-organizing behavior of cellularized gels composed of collagen type 1 that may have utility for tissue engineering is described. Depending on the starting geometry of the tissue culture well, toroidal rings of cells or hollow spheroids were prompted to form autonomously when cells were seeded onto the top of gels and the gels released from attachment to the culture well 12 to 24 h after seeding. Cells within toroids assumed distinct patterns of alignment not seen in control gels in which cells had been mixed in. In control gels, cells formed complex three-dimensional arrangements and assumed relatively higher levels of heterogeneity in expression of the fibronectin splice variant ED-A—a marker of epithelial mesenchymal transformation. The tissue-like constructs resulting from this novel self-organizing behavior may have uses in wound healing and regenerative medicine, as well as building blocks for the iterative assembly of synthetic biological structures.

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Repair of the dura mater with processed collagen devices

Cited by 107 publications

References 22 publications

Evaluation of efficacy and biocompatibility of a novel semisynthetic collagen matrix as a dural onlay graft in a large animal model

Evaluation of efficacy and biocompatibility of a novel semisynthetic collagen matrix as a dural onlay graft in a large animal model

Reconstructing spinal dura-like tissue using electrospun poly(lactide-co-glycolide) membranes and dermal fibroblasts to seamlessly repair spinal dural defects in goats

Self-Organizing Tissue-Engineered Constructs in Collagen Hydrogels

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