Repair of tooth enamel by a biomimetic mineralization frontier ensuring epitaxial growth

Abstract

The regeneration of tooth enamel, the hardest biological tissue, remains a considerable challenge because its complicated and well-aligned apatite structure has not been duplicated artificially. We herein reveal that a rationally designed material composed of calcium phosphate ion clusters can be used to produce a precursor layer to induce the epitaxial crystal growth of enamel apatite, which mimics the biomineralization crystalline-amorphous frontier of hard tissue development in nature. After repair, the damaged enamel can be recovered completely because its hierarchical structure and mechanical properties are identical to those of natural enamel. The suggested phase transformation–based epitaxial growth follows a promising strategy for enamel regeneration and, more generally, for biomimetic reproduction of materials with complicated structure.

Isolation and Identification of Potentially Pathogenic Microorganisms Associated with Dental Caries in Human Teeth Biofilms

“…Caries results in the damage of the calcified structure of the dental apatite (tooth enamel). Despite the numerous efforts made by scientists to simulate the biomineralized crystallization–amorphous boundary of hard tissue in nature and to induce the epitaxial growth of enamel with current technology, damage of tooth enamel is irreversible [ 2 , 3 ]. Dental caries is a preventable disease that places a considerable burden on the economy and quality-of-life [ 1 ].…”

Enamel Repair with Amorphous Ceramics

“…When compared to traditional enamel repair methods, our enamel repair with amorphous ceramics is outstanding (Figure i). Both the Young's modulus and hardness of E‐Amorphous ZrO 2 surpassed the values of enamel repaired by remineralization and with a composite resin, which showed a similar behavior to the E‐Sound samples (Figure i). To the best of our knowledge, the adoption of amorphous ZrO 2 in the fields of enamel repair has not been previously reported, and our enamel repair approach has been proven advantages, indicating great potential for future clinical applications.…”

Application prospect of nanomaterials mediated magnetic technology in the diagnosis and treatment of surgical diseases

“…例如: 以羟基磷灰 石纳米材料构建的人造骨和基于聚合物多肽纳米材料 自塑纳米骨浆在骨科临床得到了广泛的应用 [6~8] . 具备 原位组装生长的智能纳米补牙材料 [9] , 以及兼具导热性 好、强度高和重量轻的齿基托纳米材料等 [10~12] , 在口 腔科展现出无可比拟的优点. 高分子纳米复合材料制 作的可降解医用导管如心脏导管、腹腔导管等, 可适 应临床多样性的需要, 同时在韧性、抗拉力及生物兼 容性方面显著优于现有导管材料 [13] .…”