REPAIR OF UV-INDUCED PYRIMIDINE DIMERS IN <i>DROSOPHILA MELANOGASTER</i> CELLS IN VITRO

Trosko, James E.; Wilder, Kathy

doi:10.1093/genetics/73.2.297

Cited by 35 publications

(3 citation statements)

References 6 publications

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“…The study of TROSKO and WILDER (1973), which demonstrated dimer removal in Drosophila cells, along with the present UDS experiments, indicate that dimer removal and UV-induced excision repair are similar in both insect and mammalian cells. Since the survival of the TN-368 cells is about seven times greater than that of the '61-79 cells following UV irradiation and the UDS is about the same in both cell types, some factor other than UDS or excision repair must be responsible for the greater survival of the TN-368 cells in this instance.…”

Section: Unscheduled Dna Synthesis ( U D S )supporting

confidence: 64%

“…In view of their surprisingly high survival rate and unscheduled DNA synthesis (UDS) after X irradiation, we wanted to determine the survival rate after UV irradiation and the capacity of the TN-368 cells to repair UV-induced DNA damage. TROSKO and WILDER (1973) have reported that cultured Drosophila cells are able to eliminate UV-induced pyrimidine dimers from their DNA by both enzymatic photoreactivation and dark-repair excision mechanisms. The present study further demonstrates that the amount of UV-stimulated UDS in cabbage looper cells is similar to that found in Chinese hamster cells.…”

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confidence: 99%

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A COMPARISON OF SURVIVAL AND REPAIR OF UV-INDUCED DNA DAMAGE IN CULTURED INSECT VERSUS MAMMALIAN CELLS

et al. 1977

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Survival and unscheduled DNA synthesis (UDS) were measured in a cultured insect cell line, TN-368, and a cultured mammalian cell line, V-79-4, following exposure to several fluences of ultraviolet light. TN-368 cells were approximately seven times more resistant to the lethal effects of UV than V-79 cells, as determined by colony formation. The amount of UDS per unit amount of DNA is about the same in both cell types 4 hr after 10-50 J/m2 UV irradiations.

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Section: Unscheduled Dna Synthesis ( U D S )supporting

confidence: 64%

mentioning

confidence: 99%

A COMPARISON OF SURVIVAL AND REPAIR OF UV-INDUCED DNA DAMAGE IN CULTURED INSECT VERSUS MAMMALIAN CELLS

et al. 1977

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“…While u.v. is thought to produce pyrimidine dimers in nucleic acids, photoreversal is considered as a light-dependent enzymic process splitting these dimers (Setlow, 1966;Levin & Jordan, 1973;Trosko & Wilder, 1973). Therefore, we looked for photoreversal of the u.v.…”

Section: Wavelength Dependence Of Uv Induction Of Embryonic Defectsmentioning

confidence: 99%

Embryonic defects in Drosophila eggs after partial u.v. irradiation at different wavelengths

Bownes

Kalthoff

1974

Development

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Drosophila eggs at nuclear multiplication or blastoderm stages were regionally irradiated with monochromatic u.v. Twenty-four hours after irradiation, the results were classified as normal larvae, undifferentiated eggs, or defective embryos; the latter were subdivided into embryos with anterior or posterior defects, or embryos without anterior and posterior specificity. The irradiation of anterior (posterior) egg regions and the occurrence of anterior (posterior) defects were strongly correlated. These correlations were found using eggs of both stages. The size of the irradiated area did not obviously influence the types of defect. Dose-response curves were established irradiating anterior quarters of eggs at 245, 265, 285, or 305 nm wavelength. The frequency of embryonic defects increased with increasing u.v. doses, whereas the dosages applied did not increase the frequency of undifferentiated eggs over the control level. In eggs during nuclear multiplication 285 nm radiation was most effective in producing embryonic defects. After blastoderm formation, the efficiency of irradiation was generally increased but similar at all wavelengths employed. The induction of embryonic defects was photoreversible after u.v.-irradiation at the blastoderm stage. The data reported also include transmittance spectra of chorion and egg membrane preparations from Drosophila eggs.

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Moths: Myths and mysteries of stress resistance

Koval

1996

BioEssays

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SummaryA cabbage looper's job, in many respects not unlike our own, is to survive its early developmental period and grow up healthy, metamorphose into an adult moth, and beget the next generation of loopers. Given its numerous predators, exposure to the continuous barrage of toxic physical, chemical and biological agents delivered by humans in an effort to eradicate it, as well as nature's own hazards, such as the ultraviolet component of sunlight and hazardous natural chemicals in plants that serve to deter ingestion by the looper, it is not difficult to view the looper as a highly stressed organism. However, the looper and its lepidopteran ancestors have been quite successful at resisting such hazards since the Mesozoic Era. The purpose of this brief review will be to examine some of the potential mechanisms by which the looper and its relatives have been able Accepted to be so successful over these past 200 million years

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REPAIR OF UV-INDUCED PYRIMIDINE DIMERS IN DROSOPHILA MELANOGASTER CELLS IN VITRO

Cited by 35 publications

References 6 publications

A COMPARISON OF SURVIVAL AND REPAIR OF UV-INDUCED DNA DAMAGE IN CULTURED INSECT VERSUS MAMMALIAN CELLS

A COMPARISON OF SURVIVAL AND REPAIR OF UV-INDUCED DNA DAMAGE IN CULTURED INSECT VERSUS MAMMALIAN CELLS

Embryonic defects in Drosophila eggs after partial u.v. irradiation at different wavelengths

Moths: Myths and mysteries of stress resistance

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