Repair what is lost: Neuroprotection through neural stem cells in progressive MS

Schoonheim, Menno M.; Strijbis, Eva

doi:10.1016/j.xcrm.2023.100985

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Validating the Safety And Efficacy Of Cellular Therapies Bas...1

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2023

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“…It usually occurs in young people, and the mechanism of disease progression pathology is not yet clear. Most patients have relapses and remissions, and this relapsing-remitting treatment is mainly through immunoregulatory and immunosuppressive drugs [ 62 ]. Studies have shown that autologous hematopoietic stem cells (HSCs) transplantation treatment for MS patients has reduced the mortality rate from 7.3 % in 2000 to 0.2 % in 2016 [ 63 ].…”

Section: Validating the Safety And Efficacy Of Cellular Therapies Bas...mentioning

confidence: 99%

Current state of stem cell research in non-human primates: an overview

Wu,

Shi,

Yang

et al. 2023

Medical Review

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The remarkable similarity between non-human primates (NHPs) and humans establishes them as essential models for understanding human biology and diseases, as well as for developing novel therapeutic strategies, thereby providing more comprehensive reference data for clinical treatment. Pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells provide unprecedented opportunities for cell therapies against intractable diseases and injuries. As continue to harness the potential of these biotechnological therapies, NHPs are increasingly being employed in preclinical trials, serving as a pivotal tool to evaluate the safety and efficacy of these interventions. Here, we review the recent advancements in the fundamental research of stem cells and the progress made in studies involving NHPs.

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Section: Validating the Safety And Efficacy Of Cellular Therapies Bas...mentioning

confidence: 99%