Repeat Hepatectomy for Recurrent Colorectal Metastases

Sugawara, Gen; Isogai, Masatoshi; Kikuchi, Yuji; Suzuki, Masahiko; Yamaguchi, Akihiro

doi:10.1007/s00595-004-2945-8

Cited by 29 publications

(19 citation statements)

References 26 publications

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“…In addition, several reports have also mentioned that DFI after the first hepatectomy is an important prognostic factor (9,10,12,19). Patients with a longer DFI after the initial hepatectomy and with negative lymph nodes at the primary site may be therefore good candidates for repeat reduction surgery.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we first tried to identify the profile of patients with a long-term survival after recurrence and who had previously undergone an initial hepatectomy. There have been several reports describing the survival for repeat liver (7)(8)(9)(10)(11)(12)(13) and pulmonary (14)(15)(16)(17) resection in patients with recurrence after a curative resection of colorectal metastases. On the other hand, there have also been few reports about such treatments for extrahepatic and extra-pulmonary metastases after the initial hepatectomy (18,19).…”

Section: Introductionmentioning

confidence: 99%

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Repeat reduction surgery after an initial hepatectomy for patients with colorectal cancer

Matsuda¹,

Hotta²,

Uchiyama³

et al. 2007

Oncol Rep

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Abstract.A hepatectomy is the only treatment offering longterm survival in patients with colorectal liver metastases. However, 70-80% of the patients with a complete resection develop recurrent disease after an initial hepatectomy. Sixtyone patients who underwent metastases from colorectal carcinoma with a curative hepatectomy were entered into this study. Recurrence after hepatectomy was observed in 41 patients (67.2%). We reviewed the outcome of these 41 patients. Repeat reduction surgery was performed on 16 out of 41 patients (39.0%). According to a multivariate analysis, repeat reduction surgery and tumor size were found to be independent prognostic factors for the survival rate (p=0.007, p=0.018). Furthermore, in the group that underwent repeat reduction surgery, the rate of positive lymph nodes was significantly lower in the primary lesions, and the diseasefree interval (DFI) was also significantly longer than in the group that did not undergo repeat reduction surgery (p=0.023, p=0.045), respectively. Repeat reduction surgery was found to be the most important prognostic factor. Patients with a longer DFI and with negative lymph node findings at the primary site may therefore be considered to be good candidates for repeat reduction surgery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Repeat reduction surgery after an initial hepatectomy for patients with colorectal cancer

Matsuda¹,

Hotta²,

Uchiyama³

et al. 2007

Oncol Rep

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“…Most factors were related to the initial hepatectomy and included the following: a low serum level of [17,23,26,41] carcinoembryonic antigen (CEA) (variable threshold: less than 50 ng/mL or less than 5 ng/mL), the presence of small (less or equal to 4 cm) liver metastases, initial R0 resection, metachronous metastases, a long interval between the initial and subsequent hepatectomy (more than 6 months or more than 12 months). Other factors were related to the repeat hepatectomy including: the absence of extrahepatic disease at the time of repeat hepatectomy, R0 re-resection, low serum CEA, presence of a single metastasis, and small (less or equal to 5 cm) size of metastases.…”

Section: Prognostic Factorsmentioning

confidence: 99%

Repeat hepatectomy for liver metastases from colorectal primary cancer: A review of the literature

López

Marzano

Piardi

et al. 2012

Journal of Visceral Surgery

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“…Survival after repeated resections is as good after the first procedure. In two recently published Japanese series, the percentage of treatable patients with a second resection after the development of an intrahepatic recurrence ranged from 14.3 to 25.4%, and the 5-year survival was 49% [73,74].…”

Section: Survival After Resection Of Metastases From Colorectal Cancermentioning

confidence: 99%

Liver resections: complications and survival outcome

Grazi

2007

Expert Review of Pharmacoeconomics & Outcomes Research

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Today, liver resection represents one of the most effective therapies in the treatment of defined liver diseases, particularly for hepatocellular carcinomas, liver metastases and tumors originating from the bile ducts. There have been a number of improvements in the technique but the use of kellyclasia associated with meticulous control of hemostasis and biliostasis appears to be more effective and efficient. The procedure is still burdened with some postoperative complications, the more characteristic of which are liver insufficiency, biliary leakage and ascites. Several neoplastic diseases, both primitive and secondary, can benefit from this therapy with substantial improvement of long-term survival, and a notable change in the natural history of the disease. For these situations, a consultation should always be performed by a surgeon experienced in hepatic surgery.

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Repeat Hepatectomy for Recurrent Colorectal Metastases

Cited by 29 publications

References 26 publications

Repeat reduction surgery after an initial hepatectomy for patients with colorectal cancer

Repeat reduction surgery after an initial hepatectomy for patients with colorectal cancer

Repeat hepatectomy for liver metastases from colorectal primary cancer: A review of the literature

Liver resections: complications and survival outcome

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