Repeat pancreatectomy for pancreatic ductal cancer recurrence in the remnant pancreas after initial pancreatectomy: Is it worthwhile?

Miyazaki, Masaru; Yoshitomi, Hideyuki; Shimizu, Hiroaki; Ohtsuka, Masayuki; Yoshidome, Hiroyuki; Furukawa, Katsunori; Takayasiki, Tsukasa; Kuboki, Satoshi; Okamura, Daiki; Suzuki, Daisuke; Nakajima, Masayuki

doi:10.1016/j.surg.2013.06.050

Cited by 102 publications

(90 citation statements)

References 17 publications

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“…Similar data were reported in Japan (110), United States (107;108) and other European countrie (111). A study published in 2016 has shown a 5-year survival rate of 40.1% after resection for recurrent (112).…”

Section: Resection For Recurrent Pdacsupporting

confidence: 76%

Onco-surgical Strategies in Pancreatic Ductal Adenocarcinoma

Popescu¹,

Dumitraşcu²

2017

SGO

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Pancreatic ductal adenocarcinoma (PDAC) is an important healthcare problem because is a leading cause of death by cancer. PDAC is a highly lethal disease with a very dismal prognosis. Most patients present advanced disease at diagnosis. The management of a patient diagnosed with PDAC should be discussed in a multidisciplinary team in high-volume centers. Pancreatectomy represents the single hope of long-term survival for a patient with PDAC but the resectability rate is less than 20% of the cases. Several progresses were observed in the last years regarding the surgical and oncological approach for PDAC. The aim of the paper is to make a brief review of the current onco-surgical strategies available for patients with PDAC.

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Section: Resection For Recurrent Pdacsupporting

confidence: 76%

Onco-surgical Strategies in Pancreatic Ductal Adenocarcinoma

Popescu¹,

Dumitraşcu²

2017

SGO

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“…There have been some reports of re-sectable recurrent pancreatic carcinoma after initial pancreatectomy for pancreatic ductal carcinoma. Although the number of reported cases was limited, repeat pancreatectomy showed beneficial effects in selected patients [13].…”

Section: Discussionmentioning

confidence: 99%

Six-Year Graft Survival After Partial Pancreas Heterotopic Auto-Transplantation: A Case Report

Kobayashi

Miura

Ishikawa

et al. 2016

Transplantation Proceedings

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“…The most recent study evaluating the role of repeat pancreatectomy for recurrent pancreatic cancer by Miyazaki et al [16] evaluated 170 patients from Japan with recurrent pancreatic cancer. Sixty-seven of these had isolated recurrences within the pancreatic remnant and 11 ultimately underwent re-resection.…”

Section: Discussionmentioning

confidence: 99%

Resection of metachronous pancreatic cancer 4 years after pancreaticoduodenectomy for stage III pancreatic adenocarcinoma

et al. 2015

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Pancreatic adenocarcinoma frequently recurs in patients even after resection with curative intent. The majority of these are early recurrences and are associated with metastatic disease, thus not amenable to repeat resection. Here we report a patient who underwent completion pancreatectomy for a metachronous pancreatic adenocarcinoma. This patient initially presented with painless jaundice and computed tomography (CT) revealed a mass in the head of the pancreas. Brushings obtained at endoscopic retrograde cholangiopancreatography (ERCP) were positive for adenocarcinoma. This patient then underwent a Whipple procedure and final pathology demonstrated stage III pancreatic ductal adenocarcinoma. Adjuvant therapy included gemcitabine and erlotinib. This patient was followed with physical examinations and serial laboratory and imaging studies. There was no evidence of disease for four years at which time and sharp elevation in CA-19-9 was found. Subsequent imaging revealed a mass in the remnant pancreas. Curative intent completion pancreatectomy was then performed which confirmed the presence of pancreatic adenocarcinoma. This was followed by adjuvant Gemcitabine based chemotherapy and chemoradiation. One year later the patient is alive with no evidence of disease. Thus, in highly selected patients with recurrent or metachronous pancreatic cancer, repeat pancreatectomy can be considered, but the course of treatment should be considered in a multidisciplinary setting.

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Repeat pancreatectomy for pancreatic ductal cancer recurrence in the remnant pancreas after initial pancreatectomy: Is it worthwhile?

Cited by 102 publications

References 17 publications

Onco-surgical Strategies in Pancreatic Ductal Adenocarcinoma

Onco-surgical Strategies in Pancreatic Ductal Adenocarcinoma

Six-Year Graft Survival After Partial Pancreas Heterotopic Auto-Transplantation: A Case Report

Resection of metachronous pancreatic cancer 4 years after pancreaticoduodenectomy for stage III pancreatic adenocarcinoma

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