Repeat protein mediated synthesis of gold nanoparticles: effect of protein shape on the morphological and optical properties

Geng, Xi; Grove, Tijana Ž.

doi:10.1039/c4ra12014k

Cited by 24 publications

(21 citation statements)

References 52 publications

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“…65 Furthermore, the electrostatic repulsion due to surface charges precludes the NP fusion process during the seed formation and the initial NT growth step, 24 thus improving the colloidal stability and reducing the polydispersity. In contrast to our previous findings that protein shape may exert an appreciable impact on the growth and morphology of gold NPs, 48 the morphology as well as the optical properties of Ag NTs are independent of the size and shape of the CTPR protein. (Fig.…”

Section: Mechanistic Investigation On the Formation Of Ag Ntscontrasting

confidence: 99%

“…46,47 Previously, our group has demonstrated that the morphology and optical properties of noble metal NPs could be modulated by the concentration and the structure of the CTPR proteins. 48 CTPR is a de novo protein sequence based on the tertratricopeptide repeat family. 49 The CTPR protein and repeat proteins in general are composed of a repeating structural motif.…”

Section: Introductionmentioning

confidence: 99%

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Protein-aided formation of triangular silver nanoprisms with enhanced SERS performance

et al. 2016

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Section: Mechanistic Investigation On the Formation Of Ag Ntscontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protein-aided formation of triangular silver nanoprisms with enhanced SERS performance

et al. 2016

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“…Specifically, the consensus tetratricopeptide repeat (CTPR) module, a 34 amino acids helix‐turn‐helix motif, was used as a study case . Previously, CTPR protein‐mediated synthesis of AuNCs and Au nanoparticles have been reported . In the present study, the capability of the designed CTPR proteins to act as templates for the green synthesis and stabilization of NCs composed of Au, Ag, or Cu is explored, by the incorporation of a designed cluster coordination site based on histidines (His) (Figure ).…”

Section: Figurementioning

confidence: 99%

A Simple Approach to Design Proteins for the Sustainable Synthesis of Metal Nanoclusters

et al. 2019

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Metal nanoclusters (NCs) are considered ideal nanomaterials for biological applications owing to their strong photoluminescence (PL), excellent photostability, and good biocompatibility. This study presents a simple and versatile strategy to design proteins, via incorporation of a di‐histidine cluster coordination site, for the sustainable synthesis and stabilization of metal NCs with different metal composition. The resulting protein‐stabilized metal NCs (Prot‐NCs) of gold, silver, and copper are highly photoluminescent and photostable, have a long shelf life, and are stable under physiological conditions. The biocompatibility of the clusters was demonstrated in cell cultures in which Prot‐NCs showed efficient cell internalization without affecting cell viability or losing luminescence. Moreover, the approach is translatable to other proteins to obtain Prot‐NCs for various biomedical applications such as cell imaging or labeling.

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“…Gold nanoparticles (Au-NPs) have been widely investigated due to their uniqueness especially in biomedication [3]. The multiple surface functionality of Au-NPs ease nanobiological attachment of Au-NPs with drug [4], oligonucleotides [5], antibodies [6], and protein [7]. The optical property of Au-NPs also enables them to play a role in bioimaging by acting as marking agent [8].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Gold Nanoparticles Using Aqueous Extract ofGarcinia mangostanaFruit Peels

Lee

Shameli

Miyake

et al. 2016

Journal of Nanomaterials

132

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The synthesis of gold nanoparticles (Au-NPs) is performed by the reduction of aqueous gold metal ions in contact with the aqueous peel extract of plant, Garcinia mangostana (G. mangostana). An absorption peak of the gold nanoparticles is observed at the range of 540-550 nm using UV-visible spectroscopy. All the diffraction peaks at 2 = 38.48 ∘ , 44.85 ∘ , 66.05 ∘ , and 78.00 ∘ that index to (111), (200), (220), and (311) planes confirm the successful synthesis of Au-NPs. Mostly spherical shape particles with size range of 32.96 ± 5.25 nm are measured using transmission electron microscopy (TEM). From the FTIR results, the peaks obtained are closely related to phenols, flavonoids, benzophenones, and anthocyanins which suggest that they may act as the reducing agent. This method is environmentally safe without the usage of synthetic materials which is highly potential in biomedical applications.

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Repeat protein mediated synthesis of gold nanoparticles: effect of protein shape on the morphological and optical properties

Abstract: Engineered repeat proteins were used to elucidate the effects of protein shape on the morphology and plasmonic properties of Au NPs, which will further guide the rational design of modular protein based bioconjugate frameworks.

Cited by 24 publications

References 52 publications

Protein-aided formation of triangular silver nanoprisms with enhanced SERS performance

Protein-aided formation of triangular silver nanoprisms with enhanced SERS performance

A Simple Approach to Design Proteins for the Sustainable Synthesis of Metal Nanoclusters

Green Synthesis of Gold Nanoparticles Using Aqueous Extract ofGarcinia mangostanaFruit Peels

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