Repeat Sample Intraocular Pressure Variance in Induced and Naturally Ocular Hypertensive Monkeys

Dawson, William W.; Dawson, Judyth C.; Hope, G. M.; Brooks, Dennis; Percicot, Christine L.

doi:10.1097/01.ijg.0000185419.80241.0a

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…A series of subsequent reports (Dawson et al, 1998; Dawson et al, 2005; Komaromy et al, 1998; Toris et al, 2010) defined a variety of ocular and demographic characteristics of subsets of animals, but the genetics of the colony and the histologic features of the neuropathy have not yet been described. A second small group of ocular hypertensive animals has been identified within an NHP colony in Singapore.…”

Section: Spontaneous Nhp Glaucoma and Other Spontaneous Nhp Optic Neumentioning

confidence: 99%

The non-human primate experimental glaucoma model

Burgoyne

2015

Experimental Eye Research

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The purpose of this report is to summarize the current strengths and weaknesses of the non-human primate (NHP) experimental glaucoma (EG) model through sections devoted to its history, methods, important findings, alternative optic neuropathy models and future directions. NHP EG has become well established for studying human glaucoma in part because the NHP optic nerve head (ONH) shares a close anatomic association with the human ONH and because it provides the only means of systematically studying the very earliest visual system responses to chronic IOP elevation, i.e. the conversion from ocular hypertension to glaucomatous damage. However, NHPs are impractical for studies that require large animal numbers, demonstrate spontaneous glaucoma only rarely, do not currently provide a model of the neuropathy at normal levels of IOP, and cannot easily be genetically manipulated, except through tissue-specific, viral vectors. The goal of this summary is to direct NHP EG and non-NHP EG investigators to the previous, current and future accomplishment of clinically relevant knowledge in this model.

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Section: Spontaneous Nhp Glaucoma and Other Spontaneous Nhp Optic Neumentioning

confidence: 99%

The non-human primate experimental glaucoma model

Burgoyne

2015

Experimental Eye Research

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Genetic studies on the Cayo Santiago rhesus macaques: A review of 40 years of research

Widdig

Kessler

Bercovitch

et al. 2015

American J Primatol

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Genetic studies not only contribute substantially to our current understanding of the natural variation in behavior and health in many species, they also provide the basis of numerous in vivo models of human traits. Despite the many challenges posed by the high level of biological and social complexity, a long lifespan and difficult access in the field, genetic studies of primates are particularly rewarding because of the close evolutionary relatedness of these species to humans. The free-ranging rhesus macaque (Macaca mulatta) population on Cayo Santiago (CS), Puerto Rico, provides a unique resource in this respect because several of the abovementioned caveats are of either minor importance there, or lacking altogether, thereby allowing long-term genetic research in a primate population under constant surveillance since 1956. This review summarizes more than 40 years of genetic research carried out on CS, from early blood group typing and the genetic characterization of skeletal material via population-wide paternity testing with DNA fingerprints and short tandem repeats (STRs) to the analysis of the highly polymorphic DQB1 locus within the major histocompatibility complex (MHC). The results of the paternity studies also facilitated subsequent studies of male dominance and other factors influencing male reproductive success, of male reproductive skew, paternal kin bias, and mechanisms of paternal kin recognition. More recently, the CS macaques have been the subjects of functional genetic and gene expression analyses and have played an important role in behavioral and quantitative genetic studies. In addition, the CS colony has been used as a natural model for human adult-onset macular degeneration, glaucoma, and circadian rhythm disorder. Our review finishes off with a discussion of potential future directions of research on CS, including the transition from STRs to single nucleotide polymorphism (SNP) typing and whole genome sequencing.

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Ophthalmology of Primatomorpha: Lemurs, Tarsiers, Monkeys, Apes, and Relatives

Thomasy

2022

Wild and Exotic Animal Ophthalmology

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Repeat Sample Intraocular Pressure Variance in Induced and Naturally Ocular Hypertensive Monkeys

Abstract: Laser induced ocular hypertension in rhesus monkeys produces large IOP repeat-sample variance mean results compared to controls and natural OH.

Cited by 4 publications

References 21 publications

The non-human primate experimental glaucoma model

The non-human primate experimental glaucoma model

Genetic studies on the Cayo Santiago rhesus macaques: A review of 40 years of research

Ophthalmology of Primatomorpha: Lemurs, Tarsiers, Monkeys, Apes, and Relatives

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