Wildfires are becoming increasingly common in many parts of the world due to a variety of factors including historical fire suppression, increasing drought influenced by climate change, and increasing ignitions from humans. Indeed wildfire smoke is becoming an increasing source of air pollution people are breathing in some parts of the world. Wildfire smoke has been shown to affect numerous physical health endpoints, with clear evidence of impacts on respiratory health but less consistent and comprehensive evidence for effects on cardiovascular disease, mortality, birth outcomes and more. Additionally, we need more information on which populations are most affected by wildfire smoke, which could be affected by where people live and work and how much individuals are able to protect themselves. Public health interventions that are promoted such a as staying indoors, using personal air cleaners and masks may not be equally accessible to all individuals. Additionally, there needs to be research into how best to communicate public health guidance so that it reaches targeted populations. Health impacts from wildfires can also go beyond smoke to recovery when one’s home is lost to on-the-job dangers from wildland firefighters. Articles in this focus issue document scientific studies that address some of these topics and more.