Repeated Acquisition of a Spatial Navigation Task in Mice: Effects of Spacing of Trials and of Unilateral Middle Cerebral Artery Occlusion

Klapdor, Karin; Staay, Franz Josef van der

doi:10.1016/s0031-9384(98)00003-1

Cited by 21 publications

(9 citation statements)

References 41 publications

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“…The spacing effect in LTM is observed across a variety of tasks, including spatial reference memory (Bolding and Rudy, 2006), working memory (Klapdor and Van Der Staay, 1998), appetitive associative conditioning (Colomb, Kaiser, Chabaud, and Preat, 2009), aversive associative conditioning (Amano and Maruyama, 2011; Williams, Frame, and LoLordo, 1991; Yin, Wallach, Del Vecchio, Wilder, Zhou, Quinn, and Tully, 1994) and both sensitization and habituation (Carew, Pinsker, and Kandel, 1972; Pinsker, Carew, Hening, and Kandel, 1973; Sutton, Ide, Masters, and Carew, 2002). Effective training intervals appear to be task specific and are controlled by a number of factors, including the retention interval examined (e.g., Beck, Schroeder, & Davis, 2000; Gerber, Wustenberg, Schutz, & Menzel, 1998) and the relationship between trial duration and trial spacing (Gibbon, Baldock, Locurto, Gold, and Terrace, 1977).…”

Section: General Principles Of the Spacing Effectmentioning

confidence: 99%

“…The spacing effect does not appear to regulate the acquisition or development of STM, but strongly regulates the induction of LTM in a variety of learning tasks in a wide range of species, including pigeon (Gibbon et al, 1977), rodent (Bolding and Rudy, 2006; Klapdor and Van Der Staay, 1998; Williams et al, 1991), honeybee (Gerber et al, 1998), Drosophila (Tully et al, 1994), Hermissenda (Rogers, Talk, and Matzel, 1994), Lymnaea (Lukowiak, Cotter, Westly, Ringseis, and Spencer, 1998), and Aplysia (Carew et al, 1972). The effect of training pattern on the formation of ITM is less well studied, but has shown to be of benefit in some cases (Sutton et al, 2002).…”

Section: Cellular and Molecular Correlates Of The Spacing Effectmentioning

confidence: 99%

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Pattern and predictability in memory formation: From molecular mechanisms to clinical relevance

Philips

Kopec

Carew

2013

Neurobiology of Learning and Memory

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Most long-term memories are formed as a consequence of multiple experiences. The temporal spacing of these experiences is of considerable importance: experiences distributed over time (spaced training) are more easily encoded and remembered than either closely spaced experiences, or a single prolonged experience (massed training). In this article, we first review findings from studies in animal model systems that examine the cellular and molecular properties of the neurons and circuits in the brain that underlie training pattern sensitivity during long-term memory (LTM) formation. We next focus on recent findings which have begun to elucidate the mechanisms that support inter-trial interactions during the induction of LTM. Finally, we consider the implications of these findings for developing therapeutic strategies to address questions of direct clinical relevance.

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Section: General Principles Of the Spacing Effectmentioning

confidence: 99%

Section: Cellular and Molecular Correlates Of The Spacing Effectmentioning

confidence: 99%

Pattern and predictability in memory formation: From molecular mechanisms to clinical relevance

Philips

Kopec

Carew

2013

Neurobiology of Learning and Memory

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“…The "distribution of practice" (McGaugh 1966) or "the spacing effect" has been demonstrated in a variety of learning models, including word-pair associates in humans (Hser and Wickens 1989), appetitive conditioning in rodents (Lattal 1999), and olfactory avoidance in Drosophila (Yin et al 1995). The effect is observed in one of the most frequently tested animal learning tasks, the Morris water maze (Klapdor and Van Der Staay 1998;Gerlai 2001). In one study, animals trained with spaced trials performed better than animals trained with massed trials, and as expected, had a better memory after training (Commins et al 2003).…”

mentioning

confidence: 99%

Neurogenesis and the spacing effect: Learning over time enhances memory and the survival of new neurons

Sisti¹,

Glass²,

Shors³

2007

Learn. Mem.

159

111

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Information that is spaced over time is better remembered than the same amount of information massed together. This phenomenon, known as the spacing effect, was explored with respect to its effect on learning and neurogenesis in the adult dentate gyrus of the hippocampal formation. Because the cells are generated over time and because learning enhances their survival, we hypothesized that training with spaced trials would rescue more new neurons from death than the same number of massed trials. In the first experiment, animals trained with spaced trials in the Morris water maze outperformed animals trained with massed trials, but there was not a direct effect of trial spacing on cell survival. Rather, animals that learned well retained more cells than animals that did not learn or learned poorly. Moreover, performance during acquisition correlated with the number of cells remaining in the dentate gyrus after training. In the second experiment, the time between blocks of trials was increased. Consequently, animals trained with spaced trials performed as well as those trained with massed, but remembered the location better two weeks later. The strength of that memory correlated with the number of new cells remaining in the hippocampus. Together, these data indicate that learning, and not mere exposure to training, enhances the survival of cells that are generated 1 wk before training. They also indicate that learning over an extended period of time induces a more persistent memory, which then relates to the number of cells that reside in the hippocampus.

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“…Even subtle differences in relatedness can have large effects on behavioral responses. For example, variation in rodent strains can impact swimming behavior, visual acuity, and other factors, all of which may impact performance on spatially based tests . When thinking about animals with vastly different umwelt, methodological differences unrelated to cognitive processing ability can contribute to differential performance on cognitive tasks.…”

Section: Integrating Neurobiology and Context‐relevant Behavior Provimentioning

confidence: 99%

Reptilian Cognition: A More Complex Picture via Integration of Neurological Mechanisms, Behavioral Constraints, and Evolutionary Context

2019

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Unlike birds and mammals, reptiles are commonly thought to possess only the most rudimentary means of interacting with their environments, reflexively responding to sensory information to the near exclusion of higher cognitive function. However, reptilian brains, though structurally somewhat different from those of mammals and birds, use many of the same cellular and molecular processes to support complex behaviors in homologous brain regions. Here, the neurological mechanisms supporting reptilian cognition are reviewed, focusing specifically on spatial cognition and the hippocampus. These processes are compared to those seen in mammals and birds within an ecologically and evolutionarily relevant context. By viewing reptilian cognition through an integrative framework, a more robust understanding of reptile cognition is gleaned. Doing so yields a broader view of the evolutionarily conserved molecular and cellular mechanisms that underlie cognitive function and a better understanding of the factors that led to the evolution of complex cognition.

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Repeated Acquisition of a Spatial Navigation Task in Mice: Effects of Spacing of Trials and of Unilateral Middle Cerebral Artery Occlusion

Cited by 21 publications

References 41 publications

Pattern and predictability in memory formation: From molecular mechanisms to clinical relevance

Pattern and predictability in memory formation: From molecular mechanisms to clinical relevance

Neurogenesis and the spacing effect: Learning over time enhances memory and the survival of new neurons

Reptilian Cognition: A More Complex Picture via Integration of Neurological Mechanisms, Behavioral Constraints, and Evolutionary Context

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