Repeated administration of an aqueous spray-dried extract of the leaves of Passiflora alata Curtis (Passifloraceae) inhibits body weight gain without altering mice behavior

Braga, Andressa; Stein, Ana Cristina; Stolz, Eveline Dischkaln; Dallegrave, Eliane; Buffon, Andréia; Rego, Jean–Claude do; Gosmann, Grace; Viana, Alice Fialho; Rates, Stela Maris Kuze

doi:10.1016/j.jep.2012.10.034

Cited by 10 publications

(8 citation statements)

References 36 publications

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“…Loss of body mass and reduced food intake were also reported in a study published by Braga et al [ 34 ], upon the oral administration of 250 mg/kg/day of aqueous extract of P. alata leaves over a period of 14 days. These findings may be a sign of toxicity or may be related to possible anorectic properties of the species.…”

Section: Resultssupporting

confidence: 65%

Section: Resultsmentioning

confidence: 91%

“…A study with longer administration may show some hepatic alteration, as demonstrated by Braga et al [ 34 ] with aqueous extract of P. alata leaves, administered for 14 days, in doses of 25 and 250 mg/kg/day, which induced a reduction in liver mass, a reduction in ALT and a hydrological histological degeneration. Given the fact that the liver results reported by Braga et al [ 34 ] were obtained with 3 to 5 animals per group, longer and more detailed studies may be of scientific interest. In contrast, another study by Rudnicki et al [ 41 ], in which extract of P. alata leaves was administered to rats, demonstrated the hepatoprotective potential of the extract in the dosages of 1 and 5 mg/kg/day after 30 consecutive days of administration.…”

Section: Resultsmentioning

confidence: 91%

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Cytotoxic, Antitumor and Toxicological Profile of Passiflora alata Leaf Extract

et al. 2020

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Passiflora alata or passion fruit is a native flowering plant from Amazon, geographically spread from Peru to Brazil. The plant has long been used in folks medicine for its pharmacological properties and is included in the Brazilian Pharmacopoeia since 1929. The aim of this study was to evaluate the potential cytotoxic and antitumor activities of Passiflora alata leaf extract (PaLE) in S180-tumor bearing mice. The percentage of cell proliferation inhibition (% CPI) and IC50 in relation to 4 tumor cell lines were determined in PC3, K-562, HepG2 and S180 cell lines using the MTT assay. PaLE showed a CPI > 75% and greater potency (IC50 < 30 µg/mL) against PC3 and S180 cell lines. PaLE showed antitumor activity in treatments intraperitoneally (36.75% and 44.99% at doses of 100 and 150 mg/kg/day, respectively). Toxicological changes were shown in the reduced body mass associated with reduced food consumption, increased spleen mass associated with histopathological increase in the white pulp of the spleen and increased number of total leukocytes with changes in the percentage relationship between lymphocytes and neutrophils. Our outcomes corroborate the conclusion that PaLE has antitumor activity in vitro and in vivo with low toxicity.

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Section: Resultssupporting

confidence: 65%

Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 91%

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Cytotoxic, Antitumor and Toxicological Profile of Passiflora alata Leaf Extract

et al. 2020

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“…Thus, our data can be useful when choosing a Passiflora species and its parts (leaves and/or pericarp) for the development of potent sleep promoting phytopharmaceuticals in the future. However, it is worth to mention that a spray‐dried extract of P. alata has shown genotoxic effects in mice and rats (Boeira et al ., ) and the repeated administration of the extract inhibits body weight gain besides causing some hepatic alterations (Braga et al ., ). Although we did not observe any signs of toxicity in mice, further toxicity studies should be performed with the extracts used in this work to access its safety besides efficacy for human use.…”

Section: Discussionmentioning

confidence: 97%

Assessment of Sedative Effects of Passiflora edulis f. flavicarpa and Passiflora alata Extracts in Mice, Measured by Telemetry

et al. 2013

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Several Passiflora species have been used widely as a folk medicine due to their sedative and anxiolytic activities. In Brazil, a number of native plants of the genus Passiflora exist, but only Passiflora edulis f. flavicarpa (PE) and Passiflora alata (PA) are of commercial value. Thus, the aim of the present study was to investigate the sedative effects of aqueous extracts obtained from the pericarp as well as from the leaves of PE and PA in mice using radiotelemetry. Aqueous extracts from PE and PA were tested for effects on locomotion over 180 min in 300 mg/kg, 600 mg/kg and 1200 mg/kg, in male C57BL/6J mice after oral administration. For validation of the telemetry system, caffeine (negative control) and midazolam (positive control) were used. All tested extracts decreased locomotor activity in a dose-dependent manner in comparison to the control group. The two lower concentrations of each extract showed the highest decrease in locomotion after 24 min, while 1200 mg/kg had a significant sedative effect already after 18 min. Interestingly, aqueous extracts of PA were more active in comparison to aqueous extracts of PE and the pericarp extracts of both plants showed more pronounced effects on locomotor activity if compared to leaf extracts. In conclusion, the present study represents an innovative, objective approach to measure sedative effects of plant extracts with minimized handling-related stress and remote data collection.

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“…The main saponin constituent, triterpene quadranguloside is considered chiefly responsible for the anxiolytic activity. Consumption of high amounts of aqueous leaf extract of P. alata altered the feeding behaviour in mice resulting in reduced weight gain and also reduced the relative liver weight [6]. P. alata is used as a folklore medicine against hysteria, neurasthenia and insomnia.…”

Section: Leavesmentioning

confidence: 99%