Repeated administration of exogenous Sodium-hyaluronate improved tendon healing in an in vivo transection model

Oryan, Ahmad; Moshiri, Ali; Parizi, Abdol Hamid Meimandi; Jahromi, Alireza Raayat

doi:10.1016/j.jtv.2012.06.002

Cited by 45 publications

(75 citation statements)

References 30 publications

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“…And this cuff region undergoing reparation becomes filled with and held together by Sharpey's fibers. 9,15) But postoperative pain may resolve even in situations where the repair of the rota- tor cuff was unsuccessful-that is independently of the action of Sharpey's fibers. Thus, it would be misleading to regard resolution of pain as the only parameter of successful cuff repairs, but other parameters such as restored normal tension in ligaments should also be evaluated.…”

Section: Discussionmentioning

confidence: 99%

“…6,16,17) According to a study by Mitsui et al., 18) HA has been shown to contribute to cell proliferation and to the expression of mRNA encoding pro-collagen alpha 1 (III), which is a precursor to type III collagen, but not of pro-collagen alpha 1 (I), which is a precursor to type I collagen; as a result of their findings, they proposed the adhesion barrier role of HA. Further, Oryan et al 15) reported that HA injection into injured flexor digitorum superficialis of rabbits reduced postoperative bleeding, odema, and inflammatory reactions. And Tuncay et al 19) reported that HA controls vascular genesis by inducing the expression of vascular endothelial growth factor during the repair of Achilles tendons.…”

Section: Discussionmentioning

confidence: 99%

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Effectiveness of the Anti-adhesive Agent Protescal after Arthroscopic Rotator Cuff Repair: A Retrospective Study

Chung

Yoo

Jeong

2017

Clinics in Shoulder and Elbow

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Background: Many hyaluronic acid (HA)-based anti-adhesive agents have been commercialized for clinical use in the pharmaceutical market. But their efficacy in arthroscopic rotator cuff repairs remains elusive. To determine their efficacy, we performed a comparative analysis of the effects of two hyaluronate/carboxymethylcellulose (CMC)-based anti-adhesive agents, Protescal and Guardix. Methods: We recruited a total of 256 patients who had received an arthroscopic rotator cuff repair at our hospital between January 2014 and March 2015. Among them, 96 patients fulfilled the study's selection criteria and were enrolled as the final population sample. Thirty patients who had received a postoperative injection of Protescal were allocated into Group A. Another 30 patients who had received a postoperative injection of Guardix were allocated into Group B. As controls, 36 patients who did not receive any injection were allocated into Group C. The patients included in this study were aged between 19 and 75 years. For the clinical assessment, we measured the following clinical parameters-the visual analogue scale for pain (PVAS), the American Shoulder and Elbow Surgeons (ASES) score, and the constant score, as well as passive range of motions (ROMs)-at three time-points (preoperatively, 2-month postop eratively, and 6-month postoperatively). Results: We found that Group A compared to Group B tended to show a swifter recovery in passive anterior elevation and in internal rotation by the 2-month postoperative follow-up, but the differences were not statistically significant. Conclusions: We found that the effects of HA/CMC-based injections were minimal after arthroscopic rotator cuff repairs. (Clin Shoulder Elbow 2017;20(1):3-9)

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effectiveness of the Anti-adhesive Agent Protescal after Arthroscopic Rotator Cuff Repair: A Retrospective Study

Chung

Yoo

Jeong

2017

Clinics in Shoulder and Elbow

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“…The incidence of tendon and ligament injuries is high and several peoples are presented with these injuries to orthopedic surgery [1][2][3][4][5]. Tendon and ligaments are low vascularized tissues and have low healing capacity and capability; therefore management of tendon and ligament injuries is technically demanding [4][5][6][7][8][9][10][11][12]. Regardless of the acute or chronic nature of the tendon and ligament injuries, surgical reconstruction of the large and massive tissue defects is a more complicated situation [13][14][15][16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Tendon and Ligament Tissue Engineering, Healing and Regenerative Medicine

Moshiri¹,

Oryan²

2013

J Sports Med Doping Stud 2013

Self Cite

102

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Tendons transmit forces from muscle to bone and provide the joint function and ligaments transmit forces from bone to bone and provide joint stability. Tendon and ligament injuries have high incidence and management of tendon and ligament injuries is technically demanding because the healing response of these soft connective tissues is low. In addition, number of the available options to be considered as tissue replacement for large defects is low and healing of tendon and ligaments is faced to significant limitations. Among the available options, autografts are still gold standard but all the auto-allo and xenografts have their own limitations. Tissue engineering is a newer option but it is still primitive to be applicable extensively, in clinical setting. Tissue engineering could be divided into four categories including scaffolds, healing promotive factors, stem cells and gene therapy. To be able to have a good judgment regarding the management of tendon and ligament injuries, it is crucial to have a basic knowledge of tendon and ligament healing and regeneration. In this review, we discussed various types of tendon and ligament injuries and their incidence, and introduced the available and future options in managing large and massive tendon and ligament injuries. We specifically discussed the tissue engineering and it's advantageous and disadvantageous. To give a better clarification for the readers, we described different phases and cascades of tendon and ligament healing, modeling and remodeling, host-graft interaction after implantation of the graft and various types of prosthetic implants and finally provided some suggestions for the future investigations.

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“…Injection of corticosteroids is efficacious for short time pain relief but is problematic because of rare severe adverse effects including tendon rupture [1]. There is a growing body of evidence supporting the use of hyaluronate injections in patient with ankle sprain, adhesive capsulitis of the shoulder, patients after flexor tendon injury and hip pathology, although the mechanism of the effect have not yet been clarified [6][7][8][9][10][11]. There is some evidence that hyaluronate significantly increase proliferation of vascular Endothelial Growth Factor (VEGF) and collagen type 4 for up to six weeks after injection.…”

Section: Introductionmentioning

confidence: 99%

Lateral Epicondylitis Injection Therapy: A Safety and Efficacy Analysis of Hyaluronate versus Corticosteroid Injections

Gorelick¹

2015

Adv Tech Biol Med

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Lateral epicondylitis or tennis elbow, is a common elbow malady the extensor carpi radialis brevis origin. It is commonly treated by local injections of steroids are often associated with severe side effects and limited long term efficacy. Recently, hyaluronate is being increasingly used for the treatment of different degenerative processes of joints and soft tissue. Hyaluronate significantly and dose-dependently inhibits cell proliferation and decreased the expression level of mRNA for adhesion-related pro-collagens and cytokines. It is possible that such hyaluronate injections might improve results of injection therapy in tennis elbow syndrome.

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Repeated administration of exogenous Sodium-hyaluronate improved tendon healing in an in vivo transection model

Cited by 45 publications

References 30 publications

Effectiveness of the Anti-adhesive Agent Protescal after Arthroscopic Rotator Cuff Repair: A Retrospective Study

Effectiveness of the Anti-adhesive Agent Protescal after Arthroscopic Rotator Cuff Repair: A Retrospective Study

Tendon and Ligament Tissue Engineering, Healing and Regenerative Medicine

Lateral Epicondylitis Injection Therapy: A Safety and Efficacy Analysis of Hyaluronate versus Corticosteroid Injections

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