Repeated Administration of Vasopressin but Not Epinephrine Maintains Coronary Perfusion Pressure After Early and Late Administration During Prolonged Cardiopulmonary Resuscitation in Pigs

Wenzel, Volker; Lindner, Karl H.; Krismer, Anette C.; Miller, Egfried A.; Voelckel, Wolfgang G.; Lingnau, Werner

doi:10.1161/01.cir.99.10.1379

Cited by 183 publications

(62 citation statements)

References 31 publications

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“…Th ese studies consistently demonstrated that vasopressin doses between 0.4 and 0.8 U/kg led to a signifi cantly higher coronary perfusion pressure and myocardial blood fl ow than epinephrine and were associated with a higher percentage of successfully resusci tated animals [20][21][22][23]. However, adverse cardiovascular eff ects from vasopressin have been described as well.…”

Section: Vasopressinmentioning

confidence: 97%

Is There Still a Place for Vasopressors in the Treatment of Cardiac Arrest?

Sandroni¹,

Cavallaro²,

Antonelli³

2012

Annual Update in Intensive Care and Emergency Medicine 2012

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Section: Vasopressinmentioning

confidence: 97%

Is There Still a Place for Vasopressors in the Treatment of Cardiac Arrest?

Sandroni¹,

Cavallaro²,

Antonelli³

2012

Annual Update in Intensive Care and Emergency Medicine 2012

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“…Η ΠΠΣΑ φαί νεται ότι είναι ο μόνος αληθινός προγνωστικός παρά γοντας για την ανάκτηση της αυτόματης κυκλοφορίας (Wenzel et al 1999). Η ΠΠΣΑ, η οποία είναι υπεύθυ νη για την αιμάτωση του μυοκαρδίου, αυξάνεται κατά τη διάρκεια των θωρακικών συμπιέσεων (Paradis et al 1990).…”

Section: συζητησηunclassified

“…CPP appears to be the only prognostic factor for ROSC (Wenzel et al 1999). CPP, the pressure respon sible for supplying the myocardium with oxygen, is significantly increased during precordial compressions (Paradis et al 1990).…”

Section: συζητησηmentioning

confidence: 99%

Cardiopulmonary resuscitation in a swine model of cardiac arrest

Xanthos

Bassiakou

Papadimitriou

et al. 2017

J Hellenic Vet Med Soc

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Introduction: Cardiac arrest (CA) is a daunting medical emergency. In order to answer various questions regarding CA, and furthermore to implement novel therapeutic strategies, various animal models have been used.Aim: The aim of the present study is to describe the experimental model of CA and cardiopulmonary resuscitation (CPR), developed in our department.Materials and methods: Twenty pigs were anaesthetized and intubated. The internal jugular veins were surgically prepared, together with the carotid artery. Ventricular fibrillation (VF) was induced with an ordinary lithium battery through a pacing wire inserted into the right ventricle. The animals were resuscitated with the 2005 advanced life support algorythm (ALS), as proposed by International organizations. If the animals restored spontaneous circulation, they were further monitored for 30 minutes.Results: Nine animals restored spontaneous circulation with the implementation of the aforementioned protocol. Successful resuscitation was associated with the coronary perfusion pressure and PETCQ2 during external cardiac compressions.Conclusions: The use of an ordinary lithium battery is a safe and efficient way to induce CA. Swine baseline hemodynamics closely resemble those of human, making the swine model, a favorable model for experimental CA-induction and CPR.

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“…Despite its widespread use, a large body of experimental evidence from animal studies suggests that adrenaline may have no effect or even a detrimental effect on various measures of well-being and survival during resuscitation (Brown et al 1988;Wenzel et al 1999;Klouche et al 2003;Niemann and Garner 2005;Schwartz and Lagranha 2006) . High doses do not seem to improve survival and may increase adverse effects (Ditchey and Lindenfeld 1988;Lindner et al 1991b;Lindner et al 1991a;Hornchen et al 1993;Hilwig et al 2000;Voelckel et al 2000).…”

Section: Rationale For the Use Of Adrenaline In Cprmentioning

confidence: 99%