Repeated administration of α-hederin results in alterations in maternal zinc status and adverse developmental outcome in the rat

Duffy, Jodie Y.; Baines, Donald; Overmann, Gary J.; Keen, Carl L.; Daston, George P.

doi:10.1002/(sici)1096-9926(199711)56:5<327::aid-tera6>3.0.co;2-u

Cited by 18 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, maternal dietary restriction of Zn resulted in cardiac malformations of the outflow tract and thin myocardium in the hearts of the conceptuses. As our group has previously demonstrated, primary or secondary Zn deficiency during pregnancy results in maternal unthriftiness and fetal deficiencies (Daston et al, 1994b; Taubeneck et al, 1994; Duffy et al, 1997). Maternal dietary Zn deficiency in this study reduced maternal weight gain during pregnancy, decreased the number of viable fetuses, and resulted in smaller live fetuses at the end of gestation.…”

Section: Discussionmentioning

confidence: 80%

“…Our group has also previously demonstrated that fetal Zn deficiency can occur in the face of adequate maternal dietary Zn when the Zn‐binding protein metallothionein is upregulated in the liver, sequestering available Zn away from the fetus (Keen et al, 1993; Daston et al, 1994b; Taubeneck et al, 1994). Metallothionein induction can be triggered by stress and a diverse list of substances that are not themselves teratogenic (Daston et al, 1994a; Duffy et al, 1997). This secondary mechanism leading to fetal Zn deficiency and malformations might be a new consideration for mechanisms underlying congenital heart disease.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cardiac abnormalities induced by zinc deficiency are associated with alterations in the expression of genes regulated by the zinc‐finger transcription factor GATA‐4

Duffy

Overmann

Keen

et al. 2004

Birth Defects Research Pt B

View full text Add to dashboard Cite

Zinc (Zn) deficiency during pregnancy results in a wide variety of developmental abnormalities. The objective of this study was to determine if expression of cardiac developmental genes regulated by Zn-finger transcription factors could be modulated during dietary Zn deficiency. Rats were fed 0.5 (low Zn) or 90 (controls) microg Zn/g diet throughout pregnancy. Fetal development was examined and RNA isolated at gestation day (GD) 13 and 20. Cardiac abnormalities were detected at GD 20 in 82% of fetuses from dams fed low Zn diets compared with only 2% in controls. Cardiac developmental gene expression regulated by the Zn-finger transcription factor, GATA-4, was measured by quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). In GD 13 and 20 hearts, two genes critical for heart development, alpha-myosin heavy chain (alpha-MHC) and cardiac troponin I (cTnI), were down-regulated in Zn-deficient fetuses. Expression of alpha-MHC was 66 and 40% lower at GD 13 and 20, respectively, in fetuses from dams fed low Zn diets compared with fetuses from control dams (p<0.05). Fetal cardiac TnI RNA levels were reduced 40 and 45% at GD 13 and 20 in the Zn-deficient group compared with controls (p<0.05). Fetal cardiac transcript levels of GATA-4 and MHox, a gene regulated by a helix-loop-helix transcription factor, whose expressions are not Zn-dependent, were unaffected by diet. These data indicated that alterations in gene regulation might be an underlying mechanism of cardiac abnormalities. Dysfunction of other Zn-dependent transcription factors may be an integral part of the extensive teratogenesis associated with Zn deficiency.

show abstract

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Cardiac abnormalities induced by zinc deficiency are associated with alterations in the expression of genes regulated by the zinc‐finger transcription factor GATA‐4

Duffy

Overmann

Keen

et al. 2004

Birth Defects Research Pt B

View full text Add to dashboard Cite

show abstract

“…Several studies (e.g., Khera, 1987Khera, , 1991Keen et al, 2003a;DeSesso & Goeringer, 1990;Carey et al, 2000Carey et al, , 2003DeSesso, 1987;Daston, 1994;Taubeneck et al, 1994;Duffy et al, 1997) illustrate the necessity to consider maternal toxicity as a common contributing cause to abnormal fetal development or death. Similarly, maternal toxicity can, and does, influence the development of the young during the postnatal period (Keen et al, 2003b;Weaver et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Analysis and Integration of Developmental Neurotoxicity and Ancillary Data into Risk Assessment: A Case Study of Dimethoate

DeSesso

Watson

Keen

et al. 2008

Journal of Toxicology and Environmental Health, Part A

Self Cite

View full text Add to dashboard Cite

“…Rats when treated with α-HN exhibited Zn depilation with a decreased fetal weight and increased the incidence of abnormal fetuses at high dose (300mM/kg) [57]. Duffy et al [58] suggested a secondary Zn deficiency in rats treated with α-HN at 20 or 30mM/kg for 10 days.…”

Section: Miscellaneousmentioning

confidence: 99%

A Pharmacological Emphasized Revision on Alpha-Hederin

Islam¹

2017

JCMAH

View full text Add to dashboard Cite

Herbal medicines are a great deal of attention to investigate emphasizing on health benefits. Alpha-hederin (α-HN) is a plant-derived saponin having a number of important biological activities. However, the studies on this component are not enough. This revision aims at summarizing the biological roles of α-HN including possible mechanism of actions. This study is made on the basis of evidence observed in electronic databases, Pubmed, Science Direct, Scopus, Web of Science and miscellaneous. A number of pharmacological actions of α-HN have been investigated, including antioxidant, anti-inflammatory, antiarthritic, bronchiolytic, antifungal, and antiparasitic activities. It also has anti-histaminic and antitumor activities. In addition, desmutagenic and hepatoprotective potentials also have been shown. Physiological zinc depletion and calcium influx are the two observed toxic events in α-HN treated rodents. However, it has synergistic effects with other chemicals, while antagonistic to a number of toxicants. The α-HN may be an interesting phytochemical, therefore, more researches are necessary for it.

show abstract

Repeated administration of α-hederin results in alterations in maternal zinc status and adverse developmental outcome in the rat

Cited by 18 publications

References 21 publications

Cardiac abnormalities induced by zinc deficiency are associated with alterations in the expression of genes regulated by the zinc‐finger transcription factor GATA‐4

Cardiac abnormalities induced by zinc deficiency are associated with alterations in the expression of genes regulated by the zinc‐finger transcription factor GATA‐4

Analysis and Integration of Developmental Neurotoxicity and Ancillary Data into Risk Assessment: A Case Study of Dimethoate

A Pharmacological Emphasized Revision on Alpha-Hederin

Contact Info

Product

Resources

About