Repeated anabolic androgenic steroid treatment causes antidepressant-reversible alterations of the hypothalamic–pituitary–adrenal axis, BDNF levels and behavior

Montorsi, Francesco; Modafferi, Antonella M.E.; Togna, G.; Barone, Ylenia; Pinna, Graziano; Nicoletti, Ferdinando; Scaccianoce, Sergio

doi:10.1016/j.neuropharm.2010.01.015

Cited by 51 publications

(54 citation statements)

References 65 publications

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“…It has also been shown that juvenile rats exposed to AAS had significantly smaller testes in adulthood following withdrawal from AAS than had rats exposed to AAS in adulthood, suggesting that early AAS exposure may impose a prolonged suppression of the hypothalamic/pituitary/gonadal (HPG) axis [38]. Such age-specific peripheral effects may, in turn, lead to long-term effects on aggression and anxiety through loss of the normal androgen-dependent regulation of cortisol/cortico-sterone synthesis and of stress-induced activation of the hypothalamic/pituitary/adrenal (HPA) axis [40,41]. …”

Section: The Behavioral Effects Of Aas On Aggressionmentioning

confidence: 99%

The Sturm und Drang of anabolic steroid use: angst, anxiety, and aggression

Oberlander

Henderson

2012

Trends in Neurosciences

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Anabolic androgenic steroids (AAS) are illicitly administered to enhance athletic performance and body image. Although conferring positive actions on performance, steroid abuse is associated with changes in anxiety and aggression. AAS users are often keenly invested in understanding the biological actions of these drugs. Thus, mechanistic information on AAS actions is important not only for the biomedical community, but also for steroid users. Here we review findings from animal studies on the impact of AAS exposure on neural systems that are crucial for the production of anxiety and aggression, and compare the effects of the different classes of AAS and their potential signaling mechanisms, as well as context-, age- and sex-dependent aspects of their actions.

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Section: The Behavioral Effects Of Aas On Aggressionmentioning

confidence: 99%

The Sturm und Drang of anabolic steroid use: angst, anxiety, and aggression

Oberlander

Henderson

2012

Trends in Neurosciences

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“…We centered a large part of the efforts for this study on the analysis of a large number of steroid hormones because of their relationship with behavior [39,40] and their alterations under stress [41], depression-like conditions [42,43], sexual drive, cycles [44] and role-related behavior [45]. In the obese, estrone levels are a correlate of body fat [46].…”

Section: Discussionmentioning

confidence: 99%

Purging Behavior Modulates the Relationships of Hormonal and Behavioral Parameters in Women with Eating Disorders

Grasa

Villarreal²,

Granero³

et al. 2013

Neuropsychobiology

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Background/Aims: There is ample consensus that there is a neurophysiological basis for eating disorders (ED). Traits of personality translate into behavioral traits, purging being a well-defined transversal example. The direct implication of steroid hormones on ED has seldom been studied, despite their effects on behavior. Methods: After psychological interview analysis, 57 ED female patients (31 purgative and 26 nonpurgative) and 17 female controls were studied. Metabolic parameters and analysis of androgen, estrogen and glucocorticoid hormones were determined in parallel to the psychopathological profile (EDI-2 and SCL-90-R) and anthropometric measurements. Results: Psychometric tests showed clear differences between ED and controls, but there were few hormonal-metabolic significant differences. In purgative ED there were repeated (significant) positive correlations with corticosteroid-binding globulin (CBG) and negative correlations with sex hormone-binding globulin (SHBG) versus eating and general psychopathology. In nonpurging ED there were positive correlations for deoxycortisol, free fatty acids and albumin and negative for aspartate aminotransferase and psychopathological traits. Conclusion: The data suggest that CBG/corticosteroids and sexual hormones/SHBG are involved in purging behavior and its psychopathology and severity scores. Correlations of selected psychometric data and the CBG/SHBG levels in purging may eventually result in clinical markers. This approach may provide additional clues for understanding the pathogenesis of ED.

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“…Thus, depending on the body weight of adult individuals, dosage of diclofenac received by Group B approximately resembled the typical daily dose of diclofenac in adults. The dose of stanozolol selected was in line with previous steroid studies using rat models and considered equivalent to those abused by humans on a milligram per kilogram of body weight basis [21][22][23][24]. Group C received a dose of 5 mg/bmkg to ascertain the effects of high dosage on steroid distribution.…”

Section: Administration Of Diclofenac and Stanozololmentioning

confidence: 99%

Inhibitory Effects of Diclofenac on Steroid Glucuronidation in Vivo Do not Affect Hair-Based Doping Tests for Stanozolol

Zachár

Deshmukh

Petróczi

et al. 2017

Preprint

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In vitro studies show that diclofenac inhibits enzymatic steroid glucuronidation. This study was designed to investigate the influence of diclofenac on the excretion of stanozolol and 3'-hydroxystanozolol via analyses in hair, blood and urine in vivo in a rat study. Brown Norway rats were administered with stanozolol (weeks 1-3) and diclofenac (weeks 1-6). Weekly assessment of steroid levels in hair was complemented with spot urine and serum tests. Levels of both stanozolol and 3'-hydroxystanozolol steadily increased in hair during stanozolol treatment and decreased post-treatment, but remained readily detectable for 6 weeks. In contrast, compared to control rats, diclofenac significantly reduced urinary excretion of 3’-hydroxystanozolol which was undetectable in most samples. This is the first report of diclofenac altering steroid metabolism in vivo, detrimentally affecting detection in urine, but not in hair which holds considerable advantages over urinalysis for anti-doping tests.

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Repeated anabolic androgenic steroid treatment causes antidepressant-reversible alterations of the hypothalamic–pituitary–adrenal axis, BDNF levels and behavior

Cited by 51 publications

References 65 publications

The Sturm und Drang of anabolic steroid use: angst, anxiety, and aggression

The Sturm und Drang of anabolic steroid use: angst, anxiety, and aggression

Purging Behavior Modulates the Relationships of Hormonal and Behavioral Parameters in Women with Eating Disorders

Inhibitory Effects of Diclofenac on Steroid Glucuronidation in Vivo Do not Affect Hair-Based Doping Tests for Stanozolol

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