Repeated Antigen Challenge Modulates Expression of Follicular Dendritic Cell (FDC) Related Molecule in Draining Lymph Nodes.

Ohmori, Yoshiaki; Yoshida, Toshiko; Okabe, Motonori; Takaya, Kenichi; Koizumi, Fumitomo; Sasahara, Masakiyo

doi:10.1267/ahc.34.265

Cited by 1 publication

(1 citation statement)

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“…Therefore, in the type 3s node, it seems unlikely that the functional unit of the lymph node depends on the afferent territory (Bélisle & Sainte‐Marie, 1981b; Sainte‐Marie et al ., 1982; Nagata et al ., 1996). Activities of the follicular dendritic cells in antigen trapping (Horie et al ., 1999; Ohmori et al ., 2001) and in triggering B lymphocyte proliferation (Dubois et al ., 1999) seemed not to depend on one specific afferent route due to the common sinus in the type 3s node.…”

Section: Discussionmentioning

confidence: 99%

Gaps and fragmentation of the superficial cortex in the abdominal and pelvic lymph nodes of elderly Japanese

et al. 2003

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Gaps and fragmentation of the superficial lymph node cortex are considered to provide intranodal shunt flow between the afferent and efferent vessels. Using serial sections of 205 nodes obtained from 27 donated cadavers more than 70 years of age, we examined the histological architecture of the abdominal and pelvic nodes in elderly Japanese. Secondary follicles were rare in the specimens. Cortex gaps were, to a greater or lesser degree, found in all nodes. We classified these nodes into three types according to how often the gap occurred. Type 1 nodes, with a relatively complete shield for the afferent lymph, were most frequently found in gastric nodes, whereas type 3 nodes, with numerous gaps, were often observed in the colic, para-aortic and pelvic nodes. The type 3 nodes showed a specific architecture characterized by a fragmented superficial cortex, three-dimensionally assembled cords and a common sinus between them. Primary follicles were located in the assembled cord structures as well as at the superficial cortex. Irrespective of the type, B and T lymphocyte areas were intermingled in the cortex-like areas. The present results reveal region-specific histological heterogeneity in aged human visceral nodes. Due to increased surface areas, the type 3 architecture seemed to accelerate systemic immunity rather than act as a local barrier in the para-aortic and pelvic nodes, which are located centrally along the lymphatic drainage routes. However, thick trabeculae often seemed to develop in the type 3 sinus to decrease nodal function with aging.

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Section: Discussionmentioning

confidence: 99%