Repeated application of autologous bone marrow-derived stem cell therapy in patients with severe Buerger’s disease

Abstract

Stem cell therapy (SCT) is a promising and prospective approach in the treatment of patients with severe peripheral arterial disorders, primarily with Buerger's disease. However, very little is known about the duration of the effect of SCT, and to our best knowledge no data are available on the efficacy and safety of repeated SCT in patients with Buerger's disease. Here we report on two patients with severe Buerger's disease, who received repeated autologous bone marrow-derived stem cell therapy. Our results show that a second SCT, applied to a previously treated leg 30 or 36 months after the first treatment was efficient in both cases. After twelve months, the clinical state of the repeatedly treated lower limb improved spectacularly and non-healing ulcers healed more rapidly than after the first SCT. No severe adverse events were detected. Thus repeated SCT offers a safe and efficient treatment option for relapsing patients at the advanced stage of Buerger's disease.

The impact of repeated autologous infusion of haematopoietic stem cells in patients with liver insufficiency

“…The ideal strategy for stem cell delivery is that it should be easy to perform, minimally invasive, has very little side effects, has high cell survival and should be based on clinical settings. Moreover, under certain circumstances, the combination of more than one method may be considered [ 29 , 30 ].…”

Regenerative Capacity of Autologous Stem Cell Transplantation in Elderly: A Report of Biomedical Outcomes

“…Patients with POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein or monoclonal gammopathy and skin changes) have improvements in forced expiratory volume and total lung capacity after receiving mononuclear cells [57,58] and nonhealing ulcers in patients with Buerger's disease treated with autologous bone marrow stem cells demonstrate accelerated healing [59]. Improvements in limb ischemia due to ischemic leg ulcers have also been reported [60][61][62][63].…”