Repeated arctigenin treatment produces antidepressant- and anxiolytic-like effects in mice

Du, Yuru; Li, Wenjing; Li, Yiming; Yang, Juxiang; Wang, Xinhao; Yin, Shuo; Wang, Xi; de-la-Paz, Omar Israel Velez; Gao, Yuan; Chen, Haiying; Yin, Xi; Shi, Haishui

doi:10.1016/j.brainresbull.2018.12.005

Cited by 27 publications

(17 citation statements)

References 41 publications

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“…This suggests that the effects of arctigenin on TST and FST are not related to locomotor hyperactivity. These results indicate that arctigenin has a potential antidepressant effect, which is consistent with the previous report (Du et al, 2019).…”

Section: Resultssupporting

confidence: 94%

“…Arctigenin exerted antidepressant-and anxiolytic-like effects when administered i.p. (Du et al, 2019). However, patients with depression need to take their medication over a long time, and administration by injection is not conducive to improving patients' compliance.…”

Section: Discussionmentioning

confidence: 99%

“…We recently found that arctiin has antidepressive effects by inhibiting the activation of NF‐κB mediated by the HMGB1/TLR4‐ and TNF‐α/TNFR1‐pathways, which consequently attenuates microglial activation and neuroinflammation (Xu et al, 2020). Du et al (2019) reported that arctigenin has antidepressant‐ and anxiolytic‐like effects. However, the precise mechanisms of arctigenin antidepressant action are still unclear.…”

Section: Introductionmentioning

confidence: 99%

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Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways

Piao

Aosai

et al. 2020

British J Pharmacology

158

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Background and Purpose: Arctigenin, a major bioactive component of Fructus arctii, has been reported to have antidepressant-like effects. However, the mechanisms underlying these effects are still unclear. Neuroinflammation can be caused by excessive production of proinflammatory cytokines in microglia via high-mobility group box 1 (HMGB1)/TLR4/NF-κB and TNF-α/TNFR1/NF-κB signalling pathways, leading to depression. In this study, we have investigated the antidepressant mechanism of arctigenin by conducting in vitro and in vivo studies. Experimental Approach: The effects of chronic unpredictable mild stress (CUMS) on wild-type (WT) and TLR4 −/− mice were examined. Antidepressant-like effects of arctigenin were tested using the CUMS-induced model of depression in WT mice. The effects of arctigenin were assessed on the HMGB1/TLR4/NF-κB and TNF-α/TNFR1/NF-κB signalling pathways in the prefrontal cortex (PFC) of mouse brain and HMGB1-or TNF-α-stimulated primary cultured microglia. The interaction between HMGB1 and TLR4 or TNF-α and TNFR1 with or without arctigenin was examined by localized surface plasmon resonance (LSPR) and coimmunoprecipitation assays.

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Section: Resultssupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways

Piao

Aosai

et al. 2020

British J Pharmacology

158

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“…The underlying mechanism involves reversing hypoxia-inducible factor (HIF)-1α expression, reducing PGE2 production through the inhibition of MAPKs (p42/44 MAPK, p38 MAPK, and JNK) and NF-κB (Park et al, 2018). In the In a mouse model of depression, repeated Arctigenin treatment shows antidepressant-and anxiolytic-like effects via promoting the expressions of angiogenin (ANG), thrombopoietin (TPO), and vascular endothelial growth factor (VEGF) (Du et al, 2019). Interestingly, increasing studies have proved that Arctigenin exerts a potential therapeutic drug in cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

AMPK/SIRT1 Pathway is Involved in Arctigenin-Mediated Protective Effects Against Myocardial Ischemia-Reperfusion Injury

et al. 2021

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Arctigenin, one of the active ingredients extracted from Great Burdock (Arctium lappa) Achene, has been found to relieve myocardial infarction injury. However, the specific mechanism of Arctigenin against myocardial infarction remains largely unknown. Here, both acute myocardial ischemia-reperfusion injury (AMI/R) rat model and oxygen glucose deprivation (OGD)-induced myocardial cell injury model were constructed to explore the underlying role of AMPK/SIRT1 pathway in Arctigenin-mediated effects. The experimental data in our study demonstrated that Arctigenin ameliorated OGD-mediated cardiomyocytes apoptosis, inflammation and oxidative stress in a dose-dependent manner. Besides, Arctigenin activated AMPK/SIRT1 pathway and downregulated NF-κB phosphorylation in OGD-treated cardiomyocytes, while inhibiting AMPK or SIRT1 by the Compound C (an AMPK inhibitor) or SIRT1-IN-1 (a SIRT1 inhibitor) significantly attenuated Arctigenin-exerted protective effects on cardiomyocytes. In the animal experiments, Arctigenin improved the heart functions and decreased infarct size of the AMI/R-rats, accompanied with downregulated oxidative stress, inflammation and apoptotic levels in the heart tissues. What’s more, Arctigenin enhanced the AMPK/SIRT1 pathway and repressed NF-κB pathway activation. Taken together, our data indicated that Arctigenin reduced cardiomyocytes apoptosis against AMI/R-induced oxidative stress and inflammation at least via AMPK/SIRT1 pathway.

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“…The behavioral results showed that repeated ATG (ARC) (10, 30mg/kg) administration significantly relieved the antidepressant-and anxiolyticlike effects and repeated ARC administration at the dose of 10 and 30mg/ kg could significantly block depressive-and anxiety-like behaviors caused by CMS. Finally, ELISA results showed that ARC administration increased the serum levels of angiogenin, thrombopoietin, and vascular endothelial growth factor [60].…”

Section: Anti-depressant Activitymentioning

confidence: 95%

Therapeutic Value of Arctium Lappa Linn. – A Review

Guna¹

2019

Asian J Pharm Clin Res

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Arctium lappa (AL) (Burdock) has been used for centuries to treat a variety of ailments. Extracts of burdock root (BR) are found in a variety of herbal preparations, as well as homeopathic remedies. Arctium has been used as medicine and health supplement for hundreds of years in Europe, North America, and Asia. It is popular as a medicinal plant in traditional Chinese medicine where it is extensively used for various ailments. In recent years, immense phytochemical and pharmacological screening of Arctium has shown tremendous activity against various diseases. The plant has shown biological activity as anti-inflammatory, antiallergic, antidiabetic, antineoplastic, antimutagenic, antiviral, urolytic, antitoxic, antileukemic, hepatoprotective, growth stimulating, mild laxative, mild diuretic, depurative, diaphoretic, antibacterial, antirheumatic, and antipyretic agent. The present review highlights botanical description, distribution, chemical constituents, and the pharmacological effects of AL. The aim of this review is to correlate active principles of the plant to their pharmacological activity and thus explore the potential of AL as a source of therapeutic agents.

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Repeated arctigenin treatment produces antidepressant- and anxiolytic-like effects in mice

Cited by 27 publications

References 41 publications

Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways

Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways

AMPK/SIRT1 Pathway is Involved in Arctigenin-Mediated Protective Effects Against Myocardial Ischemia-Reperfusion Injury

Therapeutic Value of Arctium Lappa Linn. – A Review

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