Repeated-dose oral toxicity study of crude antifungal compounds produced by Lactobacillus plantarum AF1 in rats

Lee, Hwan; Lee, Myung-Yul; Chang, Hae-Choon; Lee, Jae‐Joon

doi:10.11002/kjfp.2013.20.3.394

Cited by 3 publications

(2 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of this study are in agreement with a study performed using crude antifungal compounds produced by L. plantarum AF1 (16). Neutrophils, lymphocytes, and monocytes in the male 2.0 g/kg/d group differed slightly from the control group, but these values were still within the reference range Values are expressed as mean±SE (n=5).…”

Section: Subacute Toxicity Of Hematological Parameterssupporting

confidence: 91%

“…No toxic effects were detected in rats following acute and subacute oral administration of L. plantarum AF1 (13,14). Furthermore, in another study, the acute and repeated-dose oral toxicity of crude antifungal compounds produced by L. plantarum AF1 in rodents showed these compounds were non-toxic (15,16). However, no toxicity studies have been performed on the crude antifungal compounds produced by L. plantarum HD1.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acute and Subacute Oral Toxicity Evaluation of Crude Antifungal Compounds Produced by Lactobacillus plantarum HD1 in Rats

Son¹,

Chang²,

Lee³

2015

JFN

Self Cite

View full text Add to dashboard Cite

ABSTRACT:The aim of this study was to investigate the acute and subacute oral toxicity of crude antifungal compounds produced by Lactobacillus plantarum HD1 in Sprague-Dawley rats. In the acute toxicity study, the crude antifungal compounds (0.625, 1.25, 2.5, and 5.0 g/kg) did not produce mortality, significant changes in general behavior, or changes in the gross appearance of the organs. In the subacute toxicity study, the crude antifungal compounds were administered orally to rats at doses of 0, 0.5, 1.0, and 2.0 g/kg daily for 28 days. There were no test article-related deaths, abnormal clinical signs, or body weight changes. The study also showed no significant differences between the control and treated groups in hematological and serum biochemical parameters, histopathological examination, or any other findings. These results suggest that acute or subacute oral administration of crude antifungal compounds from L. plantarum HD1 is not toxic in rats.

show abstract

Section: Subacute Toxicity Of Hematological Parameterssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Acute and Subacute Oral Toxicity Evaluation of Crude Antifungal Compounds Produced by Lactobacillus plantarum HD1 in Rats

Son¹,

Chang²,

Lee³

2015

JFN

Self Cite

View full text Add to dashboard Cite

show abstract

Oral Toxicity of Crude Antifungal Compounds Produced by Lactobacillus Plantarum AF1 and Lactobacillus Plantarum HD1

Chang¹,

Koh²,

Lee³

2015

The Korean Journal of Community Living Science

View full text Add to dashboard Cite

This study investigates the acute and repeated-dose oral toxicity of crude antifungal compounds produced by Lactobacillus plantarum AF1 (Lb. plantarum AF1) and Lactobacillus plantarum HD1 (Lb. plantarum HD1) in male and female Sprague Dawley rats. In the acute toxicity study, crude antifungal compounds (500, 1,000, and 2,000 mg/kg) did not reduce mortality or produce significant changes in general behaviors or the gross appearance of external and internal organs. In the repeated-dose toxicity study, crude antifungal compounds were administered orally to rats at doses of 500, 1,000, and 2,000 mg/kg daily for 28 days. There were no test-article-related deaths, abnormal clinical signs, or body weight changes. In addition, there were no significant differences between groups treated with crude antifungal compounds and the control group in their organ weight, hematological and serum biochemical parameters, or any other factors. These results suggest that the acute or repeated-dose oral administration of crude antifungal compounds produced by Lb. plantarum AF1 plus Lb. plantarum HD1 is not toxic in male and female rats.

show abstract

Single Oral Dose Toxicity Test and Four Weeks Repeated Oral Dose Determination Test of Crude Antifungal Compounds Produced by Bacillus subtilis SN7 in Rats

Chang¹,

Koh²,

Lee³

2016

KJCLS

View full text Add to dashboard Cite

Repeated-dose oral toxicity study of crude antifungal compounds produced by Lactobacillus plantarum AF1 in rats

Cited by 3 publications

References 23 publications

Acute and Subacute Oral Toxicity Evaluation of Crude Antifungal Compounds Produced by Lactobacillus plantarum HD1 in Rats

Acute and Subacute Oral Toxicity Evaluation of Crude Antifungal Compounds Produced by Lactobacillus plantarum HD1 in Rats

Oral Toxicity of Crude Antifungal Compounds Produced by Lactobacillus Plantarum AF1 and Lactobacillus Plantarum HD1

Single Oral Dose Toxicity Test and Four Weeks Repeated Oral Dose Determination Test of Crude Antifungal Compounds Produced by Bacillus subtilis SN7 in Rats

Contact Info

Product

Resources

About