Repeated Electroacupuncture in Obese Zucker Diabetic Fatty Rats: Adiponectin and Leptin in Serum and Adipose Tissue

Peplow, Philip V.

doi:10.1016/j.jams.2014.06.013

Cited by 11 publications

(10 citation statements)

References 18 publications

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“…S3 ). This was in concurrence with earlier reports that have shown, diet rich in high saturated fats and sugars modulates the ratio of adiponectin:leptin & HDL-C/Total-C resulting in altered glucose & lipid metabolism and development of obesity associated co-morbidities 47 , 48 . The study thus clearly showed the vulnerability of WNIN to develop obesity, which may be due to genotype-diet interaction by epigenetic mechanisms.…”

Section: Discussionsupporting

confidence: 92%

Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity

Smvk

Battula

et al. 2017

Sci Rep

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Obesity, a multifactorial disorder, results from a chronic imbalance of energy intake vs. expenditure. Apart from excessive consumption of high calorie diet, genetic predisposition also seems to be equally important for the development of obesity. However, the role of genetic predisposition in the etiology of obesity has not been clearly delineated. The present study addresses this problem by selecting three rat strains (WNIN, F-344, SD) with different genetic backgrounds and exposing them to high calorie diets. Rat strains were fed HF, HS, and HFS diets and assessed for physical, metabolic, biochemical, inflammatory responses, and mRNA expression. Under these conditions: significant increase in body weight, visceral adiposity, oxidative stress and systemic pro-inflammatory status; the hallmarks of central obesity were noticed only in WNIN. Further, they developed altered glucose and lipid homeostasis by exhibiting insulin resistance, impaired glucose tolerance, dyslipidemia and fatty liver condition. The present study demonstrates that WNIN is more prone to develop obesity and associated co-morbidities under high calorie environment. It thus underlines the cumulative role of genetics (nature) and diet (nurture) towards the development of obesity, which is critical for understanding this epidemic and devising new strategies to control and manage this modern malady.

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Section: Discussionsupporting

confidence: 92%

Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity

Smvk

Battula

et al. 2017

Sci Rep

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“…The beneficial therapeutic effects of acupuncture treatment could attribute to the regulation on lipid metabolism. A study using Obese Zucker Diabetic Fatty Rats reported that repeated acupuncture at Zhongwan (CV12) and Guanyuan (CV4) acupoints caused an increase in adiponectin and a decrease in leptin [52]. Recently, another study also demonstrated that acupuncture lowered the weight of visceral white adipose tissue (WAT) and increased the levels of protein pPKA, pPKC, pERK and TRPV1 in DRG and SC [53].…”

Section: Evidence From Animal Studiesmentioning

confidence: 99%

Mechanisms of Acupuncture Therapy for Simple Obesity: An Evidence-Based Review of Clinical and Animal Studies on Simple Obesity

Wang

Huang

Wei

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Simple obesity is a worldwide epidemic associated with rapidly growing morbidity and mortality which imposes an enormous burden on individual and public health. As a part of Traditional Chinese Medicine (TCM), acupuncture has shown the positive efficacy in the management of simple obesity. In this article, we comprehensively review the clinical and animal studies that demonstrated the potential mechanisms of acupuncture treatment for simple obesity. Clinical studies suggested that acupuncture regulates endocrine system, promotes digestion, attenuates oxidative stress, and modulates relevant molecules of metabolism in patients of simple obesity. Evidence from laboratory indicated that acupuncture regulates lipid metabolism, modulates inflammatory responses, and promotes white adipose tissue browning. Acupuncture also suppresses appetite through regulating appetite regulatory hormones and the downstream signaling pathway. The evidence from clinical and animal studies indicates that acupuncture induces multifaceted regulation through complex mechanisms and moreover a single factor may not be enough to explain the beneficial effects against simple obesity.

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“…Acupuncture group: starting from week 12, rats in the acupuncture group were given acupuncture treatment daily for 60 consecutive days. Zusanli (ST36, 5 mm lateral to the anterior tubercle of tibia [ 30 ], bilateral), Zhongwan (CV12, 9/14 above the pubic crest of the distance measured between the top of the xiphoid process and the pubic crest [ 30 ]), and Pishu (BL20, lateral to the lower border of the 11th thoracic vertebra in the back [ 31 ], bilateral) acupoints were selected. Rats were lightly immobilized, and the acupuncture needles (Suzhou Medical Appliance Factory; 0.25 mm × 15 mm) were inserted to a depth of 3 mm at the acupoints and retained for 15 min.…”

Section: Methodsmentioning

confidence: 99%

Acupuncture Decreases NF‐κB p65, miR‐155, and miR‐21 and Increases miR‐146a Expression in Chronic Atrophic Gastritis Rats

Zhang

Huang

Zhong

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Acupuncture has been used to treat chronic atrophic gastritis (CAG) in traditional Chinese medicine (TCM) for centuries. In this study, we evaluated the effect of acupuncture at Zusanli (ST36), Zhongwan (CV12), and Pishu (BL20) acupoints on weight changes of rats, histological changes of gastric glands, and expressions changes of nuclear factor-kappa B (NF-κB) p65, microRNA- (miR-) 155, miR-21, and miR-146a in CAG rats induced by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) combined with irregular diet. Consequently, we found that acupuncture treatment elevated body weight of rats significantly when compared to the model group. By observing histological changes, we found that the acupuncture group showed better improvement of gastric mucosa injury than the model group. Our results also demonstrated upregulation of NF-κB p65, miR-155, and miR-21 in gastric tissue of CAG rats and a positive correlation between miR-155 and miR-21. Relatively, expression of miR-146a was downregulated and negative correlation relationships between miR-146a and miR-155/miR-21 in CAG rats were observed. Additionally, expressions of NF-κB p65, miR-155, and miR-21 were downregulated and miR-146a was upregulated after acupuncture treatment. Taken together, our data imply that acupuncture can downregulate NF-κB p65, miR-155, and miR-21 and upregulate miR-146a expression in CAG rats. NF-κB p65, miR-155, miR-21, and miR-146a may play important roles in therapeutic effect of acupuncture in treating CAG.

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Repeated Electroacupuncture in Obese Zucker Diabetic Fatty Rats: Adiponectin and Leptin in Serum and Adipose Tissue

Cited by 11 publications

References 18 publications

Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity

Differential response of rat strains to obesogenic diets underlines the importance of genetic makeup of an individual towards obesity

Mechanisms of Acupuncture Therapy for Simple Obesity: An Evidence-Based Review of Clinical and Animal Studies on Simple Obesity

Acupuncture Decreases NF‐κB p65, miR‐155, and miR‐21 and Increases miR‐146a Expression in Chronic Atrophic Gastritis Rats

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