Repeated hyperthermia exposure increases circulating Brain Derived Neurotrophic Factor levels which is associated with improved quality of life, and reduced anxiety: A randomized controlled trial

Глазачев, О. С.; Запара, М. А.; Дудник, Е. Н.; Самарцева, В. Г.; Суста, Давиде

doi:10.1016/j.jtherbio.2019.102482

Cited by 6 publications

(4 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As such, to confidently prescribe effective and safe passive heating protocols for a wide range of (clinical) populations (e.g., older adults and persons with chronic heart failure), further research into passive heating protocols with a reduced cardiovascular strain and thermal discomfort is needed. Aside from exploring additional tolerable and yet effective protocols, chronic intervention studies could build on Glazachev et al [ 12 ] to further investigate the effects of repeated passive heating on BDNF concentration and cognitive function. Importantly, such studies should focus on persons at risk for reduced BDNF expression or cognitive function due to metabolic dysfunction or impaired mobility.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, 20 min of whole-body immersion in 42°C water also acutely elevates serum BDNF concentration [ 11 ]. In support of this acute effect, a recent trial found that 10 weeks of repeated head-out, dry hyperthermic exposure significantly increased serum BDNF concentration in young adults [ 12 ]. However, as with exercise, the cardiovascular and heat strain induced by whole-body passive heating may preclude some individuals from engaging in this activity [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating

et al. 2021

View full text Add to dashboard Cite

Brain-derived neurotrophic factor (BDNF) plays a key role in neuronal adaptations. While previous studies suggest that whole-body heating can elevate circulating BDNF concentration, this is not known for local heating protocols. This study investigated the acute effects of whole-body versus local passive heating on serum and plasma BDNF concentration. Using a water-perfused suit, ten recreationally active males underwent three 90 min experimental protocols: heating of the legs with upper-body cooling (LBH), whole-body heating (WBH) and a control condition (CON). Blood samples were collected before, immediately after and 1 h post-heating for the determination of serum and plasma BDNF concentration, platelet count as well as the BDNF release per platelet. Rectal temperature, cardiac output and femoral artery shear rate were assessed at regular intervals. Serum and plasma BDNF concentration were elevated after WBH (serum: 19.1±5.0 to 25.9±11.3 ng/ml, plasma: 2.74±0.9 to 4.58±2.0; p<0.044), but not LBH (serum: 19.1±4.7 to 22.3±4.8 ng/ml, plasma: 3.25±1.13 to 3.39±0.90 ng/ml; p>0.126), when compared with CON (serum: 18.6±6.4 to 16.8±3.4 ng/ml, plasma: 2.49±0.69 to 2.82±0.89 ng/ml); accompanied by an increase in platelet count (p<0.001). However, there was no change in BDNF content per platelet after either condition (p = 0.392). All physiological measures were elevated to a larger extent after WBH compared with LBH (p<0.001), while shear rate and rectal temperature were higher during LBH than CON (p<0.038). In conclusion, WBH but not LBH acutely elevates circulating BDNF concentration. While these findings further support the use of passive heating to elevate BDNF concentration, a larger increase in shear rate, sympathetic activity and/or rectal temperature than found after LBH appears needed to induce an acute BDNF response by passive heating.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Common acute effects of cannabis, psychedelics, and disassociatives, as well as acute stressors such as exercise, fasting, hyperthermia and psychosocial stress, include a transient increase in brain‐derived neurotrophic factor (BDNF) which is implicated in neuroprotection and neuroplasticity. 91 , 92 , 93 , 94 , 95 , 96 , 97 All psychotomimetics and various acute stressors also (typically) increase phasic dopamine release and subsequent DA sensitization, which is crucial to understanding how individuals are cross‐sensitized to psychosis via stress and/or drugs (see Figure 3 ; and below).…”

Section: Psychopharmacology Of Psychotomimetic Compensationmentioning

confidence: 99%

Psychotomimetic compensation versus sensitization

Brouwer,

Carhart‐Harris,

Raison

2024

Pharmacology Res & Perspec

View full text Add to dashboard Cite

It is a paradox that psychotomimetic drugs can relieve symptoms that increase risk of and cooccur with psychosis, such as attention and motivational deficits (e.g., amphetamines), pain (e.g., cannabis) and symptoms of depression (e.g., psychedelics, dissociatives). We introduce the ideas of psychotomimetic compensation and psychotomimetic sensitization to explain this paradox. Psychotomimetic compensation refers to a short‐term stressor or drug‐induced compensation against stress that is facilitated by engagement of neurotransmitter/modulator systems (endocannabinoid, serotonergic, glutamatergic and dopaminergic) that mediate the effects of common psychotomimetic drugs. Psychotomimetic sensitization occurs after repeated exposure to stress and/or drugs and is evidenced by the gradual intensification and increase of psychotic‐like experiences over time. Theoretical and practical implications of this model are discussed.

show abstract

“…Some clinical interventions reverse brain functional and structural changes associated with chronic pain [ 24 , 27 , 28 , 29 , 30 ]. Additionally, a strong body of evidence indicates the brain is plastic across the lifespan and non-invasive strategies (e.g., exercise, intermittent fasting, intermittent hypoxia, brief hyperthermia, or hypothermia exposure) can enhance neuroplastic responsiveness [ 31 , 32 , 33 , 34 , 35 ]. Thus, pairing strategies that promote neuroplasticity with existing chronic pain treatments might optimize their clinical effectiveness [ 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness: A Pilot Randomized Controlled Trial

et al. 2021

View full text Add to dashboard Cite

Chronic pain affects mental and physical health and alters brain structure and function. Interventions that reduce chronic pain are also associated with changes in the brain. A number of non-invasive strategies can promote improved learning and memory and increase neuroplasticity in older adults. Intermittent fasting and glucose administration represent two such strategies with the potential to optimize the neurobiological environment to increase responsiveness to recognized pain treatments. The purpose of the pilot study was to test the feasibility and acceptability of intermittent fasting and glucose administration paired with a recognized pain treatment activity, relaxation and guided imagery. A total of 32 adults (44%W, 56%M), 50 to 85 years of age, with chronic knee pain for three months or greater participated in the study. Four sessions were completed over an approximate two-week period. Findings indicate the ability to recruit, randomize, and retain participants in the protocol. The procedures and measures were reasonable and completed without incident. Participant adherence was high and exit interview feedback positive. In summary, the pilot study was feasible and acceptable, providing the evidence necessary to move forward with a larger clinical trial.

show abstract

Repeated hyperthermia exposure increases circulating Brain Derived Neurotrophic Factor levels which is associated with improved quality of life, and reduced anxiety: A randomized controlled trial

Cited by 6 publications

References 22 publications

Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating

Serum and plasma brain-derived neurotrophic factor concentration are elevated by systemic but not local passive heating

Psychotomimetic compensation versus sensitization

Optimizing Chronic Pain Treatment with Enhanced Neuroplastic Responsiveness: A Pilot Randomized Controlled Trial

Contact Info

Product

Resources

About