Repeated inspiratory occlusions in anesthetized rats acutely increase blood coagulability as assessed by thromboelastography

Othman, Maha; Gordon, S.P.; Iscoe, Steve

doi:10.1016/j.resp.2010.01.010

Cited by 14 publications

(9 citation statements)

References 58 publications

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“…As demonstrated above, many studies have attempted to determine the relationship between OSA and coagulation. However, only two studies to date have examined whole blood coagulability and OSAone animal model of OSA (85) and one study involving human subjects (86). Both studies used thromboelastography, which is a global assay of hemostatic function.…”

Section: Whole Blood Coagulability (Table 10)mentioning

confidence: 99%

Coagulability in Obstructive Sleep Apnea

Liak

Fitzpatrick

2011

Canadian Respiratory Journal

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There is considerable evidence that OSA is associated with a procoagulant state. Several factors are involved in the procoagulant state associated with OSA. There is a need for adequately powered clinical studies involving well-matched control groups to address potential confounding variables, and to accurately delineate the individual factors involved in the procoagulant state associated with OSA and their response to treatment.

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Section: Whole Blood Coagulability (Table 10)mentioning

confidence: 99%

Coagulability in Obstructive Sleep Apnea

Liak

Fitzpatrick

2011

Canadian Respiratory Journal

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“…In this respect, thromboelastography, a unique test of hemostasis, has been suggested for risk evaluation of future cardiovascular disease in patients with OSAS. 33 Hemostatic measurements from studies that investigate OSAS are difficult to compare except if it addresses a relationship between AHI, the severity index of OSAS, and hemostasis variables. In this study, however, we could not document a significant relationship between ADP aggregation and the severity of OSAS, indicated by AHI or the oxygenation parameters.…”

Section: Discussionmentioning

confidence: 99%

Adenosine Diphosphate-Induced Platelets Aggregability in Polysomnographically Verified Obstructive Sleep Apnea

Alkhiary

Morsy

Yousef

et al. 2015

Clin Appl Thromb Hemost

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Obstructive sleep apnea syndrome (OSAS) is a risk factor for arterial thrombosis and cardiovascular morbidity. Activated platelets play key roles in the development of atherothrombosis, thus may be involved in these complications of OSAS. Herein, we evaluated the relationship between severity of OSAS and the degree of platelet aggregates as a marker of activated platelets in 64 patients with OSAS. Platelet aggregations were determined by means of optical aggregometry, using adenosine diphosphate (ADP) as an agonist. Compared with the control group, ADP-induced platelet aggregability was increased in patients with total OSAS, severe OSAS, and in mild to moderate OSAS. Moreover, ADP-induced platelet aggregation was correlated with the Epworth sleepiness scale (ESS) in patients with severe OSAS. Obstructive sleep apnea syndrome is associated with enhanced platelets aggregations, which may predispose the cardiovascular sequels. The ESS may be important in predicting platelet activation and thus atherothrombotic complications in those with OSAS.

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“…This model allows the study of the potential consequences of strenuous breathing against an obstructed airway and can be used to study the cardiovascular consequences and risk factors of OSA (e.g., systemic inflammation and coagulation), and to investigate the mechanisms that underlie OSA (Salejee et al, 1993; Nácher et al, 2007, 2009; Almendros et al, 2008, 2011; Othman et al, 2010). However, to the best of our knowledge, no study has yet shown that this obstruction model is able to mimic HT related to OSA.…”

Section: What Models Are Available To Study Ht Related To Osa?mentioning

confidence: 99%

The efficacy of antihypertensive drugs in chronic intermittent hypoxia conditions

Diogo

Monteiro

2014

Front. Physiol.

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Sleep apnea/hypopnea disorders include centrally originated diseases and obstructive sleep apnea (OSA). This last condition is renowned as a frequent secondary cause of hypertension (HT). The mechanisms involved in the pathogenesis of HT can be summarized in relation to two main pathways: sympathetic nervous system stimulation mediated mainly by activation of carotid body (CB) chemoreflexes and/or asphyxia, and, by no means the least important, the systemic effects of chronic intermittent hypoxia (CIH). The use of animal models has revealed that CIH is the critical stimulus underlying sympathetic activity and hypertension, and that this effect requires the presence of functional arterial chemoreceptors, which are hyperactive in CIH. These models of CIH mimic the HT observed in humans and allow the study of CIH independently without the mechanical obstruction component. The effect of continuous positive airway pressure (CPAP), the gold standard treatment for OSA patients, to reduce blood pressure seems to be modest and concomitant antihypertensive therapy is still required. We focus this review on the efficacy of pharmacological interventions to revert HT associated with CIH conditions in both animal models and humans. First, we explore the experimental animal models, developed to mimic HT related to CIH, which have been used to investigate the effect of antihypertensive drugs (AHDs). Second, we review what is known about drug efficacy to reverse HT induced by CIH in animals. Moreover, findings in humans with OSA are cited to demonstrate the lack of strong evidence for the establishment of a first-line antihypertensive regimen for these patients. Indeed, specific therapeutic guidelines for the pharmacological treatment of HT in these patients are still lacking. Finally, we discuss the future perspectives concerning the non-pharmacological and pharmacological management of this particular type of HT.

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Repeated inspiratory occlusions in anesthetized rats acutely increase blood coagulability as assessed by thromboelastography

Cited by 14 publications

References 58 publications

Coagulability in Obstructive Sleep Apnea

Coagulability in Obstructive Sleep Apnea

Adenosine Diphosphate-Induced Platelets Aggregability in Polysomnographically Verified Obstructive Sleep Apnea

The efficacy of antihypertensive drugs in chronic intermittent hypoxia conditions

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