Repeated ketamine treatment induces sex-specific behavioral and neurochemical effects in mice

Thelen, Connor; Sens, Jonathon P.; Mauch, Joseph; Pandit, Radhika; Pitychoutis, Pothitos M.

doi:10.1016/j.bbr.2016.06.041

Cited by 63 publications

(53 citation statements)

References 44 publications

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“…On the other hand, there is also emerging evidence that repeated ketamine treatment (daily injections of 10 mg/kg for 21 days) effectively sustains the antidepressant response in male mice, whereas it may actually worsen depression and anxiety-related phenotypes in female mice [60] (Table 3). Therefore, further research into the sex specific effects of ketamine is warranted.…”

Section: Sex Differences In Ketamine's Antidepressant Response At Basmentioning

confidence: 99%

Sex Differences in the Antidepressant Effects of Ketamine in Animal Models of Depression

Adu-Nti¹,

Ghartey‐Kwansah²,

Aboagye³

2019

Int J Depress Anxiety

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Major depressive disorder (MDD) is the most common psychiatric disease and it affects millions of people across the world. Patients suffering from MDD consistently complain about cognitive disturbances, significantly worsening the burden of this illness. The second most frequent mental illness in Europe is mood disorders and they are dominated by MDD, a-ecting 7% of the population. The recent discovery that the N-methyl-D-aspartate receptor (NMDAR) antagonist; ketamine; a revolutionary novel antidepressant, rapidly relieves depressive symptoms and suicidal imaginations, particularly amongst those with treatment-resistant depression have generated a new wave of excitement. This article discusses the sex differences that exist in depressive patients, summarizes the antidepressant activity of ketamine and reviews the mechanisms underlying the rapid antidepressant effects of ketamine. It further discusses the sexual differences in the antidepressant activity of ketamine in preclinical studies.

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Section: Sex Differences In Ketamine's Antidepressant Response At Basmentioning

confidence: 99%

Sex Differences in the Antidepressant Effects of Ketamine in Animal Models of Depression

Adu-Nti¹,

Ghartey‐Kwansah²,

Aboagye³

2019

Int J Depress Anxiety

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show abstract

“…Interestingly, daily injections of 10 mg/kg ketamine in mice for 21 days induce anti- or pro-depressant-like effects in males or females, respectively [12], which, while still potentially linked to the females’ higher sensitivity to ketamine, highlights the importance of administration paradigm in preclinical studies and warrants further investigations into the interaction between the treatment regimen and ketamine’s sex-dependent behavioral outcome.…”

Section: Sex Differences In Effects Of Ketamine Under Baseline Conditmentioning

confidence: 99%

Integrative analysis of sex differences in the rapid antidepressant effects of ketamine in preclinical models for individualized clinical outcomes

Saland

Duclot

Kabbaj

2017

Current Opinion in Behavioral Sciences

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In major depressive disorder, women exhibit higher lifetime prevalence and different antidepressant response rates than men, which illustrates the importance of examining individual differences in the pathophysiology of depression and therapeutic response. In recent years, the consideration of sex in related preclinical research has thus gained interest—particularly in light of novel evidence for rapid-acting antidepressants. Notably, the literature recently revealed a higher sensitivity of females to the antidepressant effects of the N-methyl-D-aspartate receptor antagonist ketamine, in both baseline and preclinical conditions. Combined with its fast-acting and relatively sustained properties, this evidence highlights ketamine as a particularly interesting therapeutic alternative for this sensitive population, and supports the value in considering sex as a critical factor for improved individualized therapeutic strategies.

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“…25 Therefore, fur ther research into the sexspecific effects of ketamine is war ranted. It is also important to note that such preclinical studies involving prolonged expos ure to ketamine over sev eral days have also reported neurotoxicity in animal models of schizophrenia.…”

Section: J Psychiatry Neurosci 2017;42(4)mentioning

confidence: 99%

Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism

Aleksandrova

Phillips

Wang

2017

JPN

186

124

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Repeated ketamine treatment induces sex-specific behavioral and neurochemical effects in mice

Cited by 63 publications

References 44 publications

Sex Differences in the Antidepressant Effects of Ketamine in Animal Models of Depression

Sex Differences in the Antidepressant Effects of Ketamine in Animal Models of Depression

Integrative analysis of sex differences in the rapid antidepressant effects of ketamine in preclinical models for individualized clinical outcomes

Antidepressant effects of ketamine and the roles of AMPA glutamate receptors and other mechanisms beyond NMDA receptor antagonism

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