Repeated Low-dose Aerosolized Dust Mite Allergen Exposure In Asthmatic And Non-asthmatic Dust Mite Allergic Patients In An Environmental Exposure Chamber Induces Specific Asthma Symptoms As Well As Allergic Rhinoconjunctivitis Symptoms

Efficacy and safety of sublingual tablets of house dust mite allergen extracts: Results of a dose-ranging study in an environmental exposure chamber

“…In the published literature and experience at Cetero Research/PRACS Institute, aerosolization of Der p 1 allergen in this concentration range has been shown to induce both nasal and nonnasal symptoms in patients allergic to dust mite. 19 Randomized subjects underwent five, 4-hour allergen challenges during the study: at baseline and after 1, 2, 4, and 6 treatment months (Fig 1). During the challenges, participants recorded the severity of their 4 nasal symptoms (rhinorrhea, nasal congestion, sneezing, and nasal pruritus) on a scale of 0 (no symptoms), 1 (mild), 2 (moderate) to 3 (severe).…”

Aeroallergens in Canada: Distribution, Public Health Impacts, and Opportunities for Prevention

“…When an individual has this type of imbalanced immune system, repeated exposures to a myriad of specific proteins (e.g., pollen, certain molds, dust mite feces, eggs, peanuts) can induce the creation of IgE antibodies [ 10 ]. These initial encounters with the proteins produce a sensitization to these specific molecules, and subsequent exposures will trigger symptoms each time [ 10 , 11 ].…”