Repeated psychosocial stress causes glutamic acid decarboxylase isoform-67, oxidative-Nox-2 changes and neuroinflammation in mice: Prevention by treatment with a neuroactive flavonoid, morin

Ben‐Azu, Benneth; Emokpae, Osagie; Ajayi, Abayomi Mayowa; Jarikre, Theophilus Aghogho; Orhode, Valiant; Aderibigbe, Adegbuyi Oladele; Umukoro, Solomon; Iwalewa, Ezekiel O.

doi:10.1016/j.brainres.2020.146917

Cited by 37 publications

(13 citation statements)

References 76 publications

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“…Stressors produced in several environments in which the individual develops, such as family, work, academic and socio-environmental, lead to the development of serious psychiatric disorders, among which post-traumatic stress disorder, anxiety and depression stand out [ 1 , 2 ]. The same effects of stress have been identified at preclinical research [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 62%

Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause

et al. 2023

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Women have a high susceptibility to the negative effects of stress. Hormonal changes experienced throughout their reproductive life partially contribute to a higher incidence of anxiety and depression symptoms, particularly, during natural or surgical menopause. In preclinical research, the flavonoid chrysin (5,7-dihydroxyflavone) exerts anxiolytic- and anti-despair-like effects; however, it is unknown whether chrysin exerts a protective effect against the behavioral changes produced by acute stress on locomotor activity and behavioral despair in rats at 12-weeks post-ovariectomy. Ovariectomized female Wistar rats were assigned to eight groups: vehicle group (10% DMSO), three groups with chrysin and three groups with the same dose of allopregnanolone (0.5, 1, and 2 mg/kg), and one group with diazepam (2 mg/kg). The treatments were administered for seven consecutive days and the effects were evaluated in the locomotor activity and swimming tests. Chrysin (2 mg/kg) increased the latency to first immobility and decreased the total immobility time in the swimming test as the reference drugs allopregnanolone and diazepam (2 mg/kg); while locomotor activity prevented the behavioral changes produced by swimming. In conclusion, chrysin exerts a protective effect against the behavioral changes induced by acute stress, similarly to the neurosteroid allopregnanolone and the benzodiazepine diazepam in rats subjected to a surgical menopause model.

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Section: Introductionmentioning

confidence: 62%

Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause

et al. 2023

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“…Rats were considered immobile when completely motionless or suspended passively. Immobility time was recorded as a depressive behavior index in this experimental model (Ben‐Azu et al., 2020; Gosavi & Kamdi, 2020).…”

Section: Methodsmentioning

confidence: 99%

Neuroprotective effects of Olea europaea L. fruit extract against cigarette smoke‐induced depressive‐like behaviors in Sprague–Dawley rats

et al. 2021

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Depression is broadly acclaimed as a mental health anomaly and despite advancements in the development of antidepressant drugs, they are linked with side effects. Dietary modifications and medicinal plants like olives can be used as effective strategies due to their antioxidant, immune‐modulatory, antiinflammatory, and anticonvulsant properties. Considering the compositional alterations in olive fruits during ripening, the antidepressant potential of olive fruits at different degrees of ripeness, that is, un‐ripened (green) and ripened (black) was investigated. Rats were randomly divided into five groups: G0 (Normal diet), G1 (Normal diet + smoke exposure (SE), G2 (Normal diet + SE + Citalopram), G3 (Normal diet + SE + Green olive extract), and G4 (Normal diet + SE + Black olive extract). Depressive‐like behaviors were induced in all groups through cigarette smoke exposure except G0. Green and black olive extracts prevented depressive behaviors by reducing the immobility time of rats in forced swim test and tail suspension test while increased the latency to respond in hot plate assay. Moreover, lipid peroxidation in brain tissue was reduced with citalopram, green, and black olive extracts. Additionally, treatments also enhanced the antioxidant pool of brain tissues. Histological examination revealed that olive extracts and citalopram prevented cigarette smoke‐induced moderate to severe necrosis and congestion in the brain parenchyma and elucidated antidepressant potential by improving the expression of monoamine oxidase‐A, solute carrier family 6 member 4, and brain‐derived neurotrophic factor genes. Conclusively, olives may act as a promising antidepressant agent in ameliorating cigarette smoke‐induced depressive‐like behaviors. Practical applications Olive extracts at both ripening stages revealed an antidepressant‐like effect almost similar to the standard antidepressant drug and also prevented oxidative damages. Therefore, from the current findings, it can be recommended that food ingredients with antidepressant potential like olives should be incorporated in future interventions to combat depression/psychiatric anomalies and diet therapy should be encouraged to alleviate lifestyle‐related disorders.

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“…Lots of researches have intensely demonstrated the anti-neuroinflammatory properties of morin ( 43 , 44 ). Morin has been reported to decrease the secretion of NO, TNF-α, and IL-6, and suppress the protein expression of NF-κB in the striatum, prefrontal cortex and hippocampus from social defeat stress-induced mice ( 45 ) and in the hippocampus from Aβ 1-42 -induced AD rats ( 46 ). Besides, morin represses the production of nNOS and GFAP in brain of ifosfamide-induced neurotoxicity rats via decreasing the production of NF-κB and JNK, and increasing Nrf2 expression ( 47 ).…”

Section: Effects Of Natural Flavonoids On Neuroinflammationmentioning

confidence: 99%

Beneficial effects of natural flavonoids on neuroinflammation

et al. 2022

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Neuroinflammation is the fundamental immune response against multiple factors in the central nervous system and is characterized by the production of inflammatory mediators, activated microglia and astrocytes, and the recruitment of innate and adaptive immune cells to inflammatory sites, that contributes to the pathological process of related brain diseases, such as Alzheimer’s disease, Parkinson’s disease, depression, and stroke. Flavonoids, as a species of important natural compounds, have been widely revealed to alleviate neuroinflammation by inhibiting the production of pro-inflammatory mediators, elevating the secretion of anti-inflammatory factors, and modulating the polarization of microglia and astrocyte, mainly via suppressing the activation of NLRP3 inflammasome, as well as NF-κB, MAPK, and JAK/STAT pathways, promoting Nrf2, AMPK, BDNF/CREB, Wnt/β-Catenin, PI3k/Akt signals and SIRT1-mediated HMGB1 deacetylation. This review will provide the latest and comprehensive knowledge on the therapeutic benefits and mechanisms of natural flavonoids in neuroinflammation, and the natural flavonoids might be developed into food supplements or lead compounds for neuroinflammation-associated brain disorders.

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Repeated psychosocial stress causes glutamic acid decarboxylase isoform-67, oxidative-Nox-2 changes and neuroinflammation in mice: Prevention by treatment with a neuroactive flavonoid, morin

Cited by 37 publications

References 76 publications

Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause

Behavioral Despair Is Blocked by the Flavonoid Chrysin (5,7-Dihydroxyflavone) in a Rat Model of Surgical Menopause

Neuroprotective effects of Olea europaea L. fruit extract against cigarette smoke‐induced depressive‐like behaviors in Sprague–Dawley rats

Beneficial effects of natural flavonoids on neuroinflammation

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