Repeated social defeat stress exacerbates lipopolysaccharide-induced behavioural deficits in mice: ameliorative role of Chrysophyllum albidum fruit extract through anti-neuroinflammation, antioxidant and neurochemical balance

Ajayi, Abayomi Mayowa; Ben‐Azu, Benneth; Ogunkolade, Gracious E.; Melete, John; Oyedele, Ayomide T.; Umukoro, Solomon

doi:10.1007/s11011-022-01053-x

Cited by 4 publications

(2 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gallic acid, chlorogenic acid, rutin, quercetin, resveratrol, syringic acid, and kuromanine are renowned for their antioxidant and anti-inflammatory properties. They have demonstrated the ability to shield against oxidative stress and neuroinflammation, thereby holding promise in potentially reducing the risk of neurodegenerative diseases [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Fermented Blueberry and Black Rice Against Particulate Matter 2.5 μm-Induced Inflammation In Vitro and In Vivo

Bayazid,

Jeong,

Azam

et al. 2023

Preprint

View full text Add to dashboard Cite

The escalating prevalence of particulate matter (PM) has raised serious concerns regarding its detrimental effects on human health. This study aimed to investigate the potential of fermented blueberry and black rice (FBBR) in mitigating the effects of PM2.5, both in SH-SY5Y cells and mice exposed to PM2.5. Various assays, including MTT, NO, western blot, ELISA, and behavioral studies (MWM and Y-maze) were conducted. Our results demonstrated that PM2.5 induced significant cytotoxicity and elevated nitric oxide (NO) production at a concentration of 100μg/mL of PM2.5 in SH-SY5Y cells. Additionally, administration of FBBR effectively attenuated PM2.5-induced cytotoxicity and suppressed NO production in SH-SY5Y cells. In an intranasal instilled mice model, exposure to 10 mg/kg body weight of PM2.5 resulted in cognitive impairments. However, FBBR treatment ameliorated these impairments in both the Y-maze and MWM tests in PM2.5-exposed mice. Furthermore, FBBR administration increased the expression of brain-derived neurotrophic factor (BDNF) and reduced inflammatory markers in the brains of PM2.5-exposed SH-SY5Y cells. These findings underscore the detrimental effects of PM2.5 on the nervous system and highlight the potential of FBBR as a nutraceutical agent for mitigating these effects. Overall, this study emphasizes the urgency of addressing the harmful impact of PM2.5 on the nervous system and suggests the promising role of FBBR as a protective intervention against the adverse effects associated with PM2.5 exposure.

show abstract

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Fermented Blueberry and Black Rice Against Particulate Matter 2.5 μm-Induced Inflammation In Vitro and In Vivo

Bayazid,

Jeong,

Azam

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…In addition, genes related to the HPA axis may influence the risk of depressive and posttraumatic stress symptoms contingent on the experience of child abuse ( Gillespie et al, 2009 ). The social defeat stress, an important animal model, which mice and rats are exposed to repeated social stress causes biological alterations, such as changes in corticosterone levels and it is can be related with genetic alterations ( Ajayi et al, 2022 ; Avgustinovich et al, 2022 ).…”

Section: Depression and Resilience To Stress: Genetic Factorsmentioning

confidence: 99%

Neurobiological mechanisms of mood disorders: Stress vulnerability and resilience

Marcolongo-Pereira

Castro

Barcelos

et al. 2022

Front. Behav. Neurosci.

View full text Add to dashboard Cite

Stress is an important factor in the development of several human pathologies. The response of rodents and humans to stress depends on many factors; some people and rodents develop stress-related mood disorders, such as depression and anxiety in humans, depression-like and anxiety-like behavior in mice and rats, while others report no new psychological symptoms in response to chronic or acute stress, and are considered susceptible and resilient to stress, respectively. Resilience is defined as the ability to thrive in the face of adversity and is a learned process that can help protect against occupational stressors and mental illnesses. There is growing interest in the underlying mechanisms involved in resilience and vulnerability to depression caused by stress, and some studies have demonstrated that individual variability in the way animals and humans respond to stress depends on several mechanisms, such as oxidative stress, neuronal plasticity, immunology and genetic factors, among others not discussed in this review, this review provides a general overview about this mechanism.

show abstract

Sleep deprivation aggravates lipopolysaccharide-induced anxiety, depression and cognitive impairment: The role of pro-inflammatory cytokines and synaptic plasticity-associated proteins

Zhang,

Wei,

Feng

et al. 2024

Journal of Neuroimmunology

View full text Add to dashboard Cite

Repeated social defeat stress exacerbates lipopolysaccharide-induced behavioural deficits in mice: ameliorative role of Chrysophyllum albidum fruit extract through anti-neuroinflammation, antioxidant and neurochemical balance

Cited by 4 publications

References 77 publications

Neuroprotective Effects of Fermented Blueberry and Black Rice Against Particulate Matter 2.5 μm-Induced Inflammation In Vitro and In Vivo

Neuroprotective Effects of Fermented Blueberry and Black Rice Against Particulate Matter 2.5 μm-Induced Inflammation In Vitro and In Vivo

Neurobiological mechanisms of mood disorders: Stress vulnerability and resilience

Sleep deprivation aggravates lipopolysaccharide-induced anxiety, depression and cognitive impairment: The role of pro-inflammatory cytokines and synaptic plasticity-associated proteins

Contact Info

Product

Resources

About