Repeated toluene exposure alters the synaptic transmission of layer 5 medial prefrontal cortex

Cruz, Silvia L.; Torres-Flores, Mayra; Galván, Emilio J.

doi:10.1016/j.ntt.2019.02.002

Cited by 11 publications

(8 citation statements)

References 22 publications

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“…The effects of inhalants on the central nervous system (CNS), including cognition, have been relatively well studied, and it is thought that inhibited N ‐methyl‐D‐aspartate (NMDA) receptor signaling and region‐specific changes to glutamatergic and gamma‐Aminobutyric acid (GABA)‐ergic signaling underpin these effects . However, inhalants can also have a wide range of peripheral effects throughout the body, including on the renal, cardiovascular, and pulmonary systems .…”

Section: The Effects Of Inhalant Abuse On Energy Balancementioning

confidence: 58%

The effect of adolescent inhalant abuse on energy balance and growth

Crossin

Qama

Andrews

et al. 2019

Pharmacology Res & Perspec

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The abuse of volatile solvents such as toluene is a significant public health concern, predominantly affecting adolescents. To date, inhalant abuse research has primarily focused on the central nervous system; however, inhalants also exert effects on other organ systems and processes, including metabolic function and energy balance. Adolescent inhalant abuse is characterized by a negative energy balance phenotype, with the peak period of abuse overlapping with the adolescent growth spurt. There are multiple components within the central and peripheral regulation of energy balance that may be affected by adolescent inhalant abuse, such as impaired metabolic signaling, decreased food intake, altered dietary preferences, disrupted glucose tolerance and insulin release, reduced adiposity and skeletal density, and adrenal hypertrophy. These effects may persist into abstinence and adulthood, and the long‐term consequences of inhalant‐induced metabolic dysfunction are currently unknown. The signs and symptoms resulting from chronic adolescent inhalant abuse may result in a propensity for the development of adult‐onset metabolic disorders such as type 2 diabetes, however, further research investigating the long‐term effects of inhalant abuse upon energy balance and metabolism are needed. This review addresses several aspects of the short‐ and long‐term effects of inhalant abuse relating to energy and metabolic processes, including energy balance, intake and expenditure; dietary preferences and glycemic control; and the dysfunction of metabolic homeostasis through altered adipose tissue, bone, and hypothalamic‐pituitary‐adrenal axis function.

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Section: The Effects Of Inhalant Abuse On Energy Balancementioning

confidence: 58%

The effect of adolescent inhalant abuse on energy balance and growth

Crossin

Qama

Andrews

et al. 2019

Pharmacology Res & Perspec

View full text Add to dashboard Cite

show abstract

“…This is in accordance with Scheepers research entitled Assessment of Exposure of Gas Station Attendants in Sri Lanka to Benzene, Toluene and Xylene (BTX) with a reduction in work duration to 40 hours/week can reduce BTX concentrations in workers' blood to safe limits 9 . Repeated toluene exposure can cause cognitive impairment in mice 10 . Based on table 2, the average glutathione concentration in the Osowilangun shoe home industry workers was 35,655 µg/L.…”

Section: Resultsmentioning

confidence: 99%

Correlation of Toluene Safe Duration (Hours/Day) and Glutathione Concentration, Malondialdehyde and Neurotoxic Symptoms in Osowilangun Shoe Home Industry Workers

Ningrum

Tualeka

Jalaludin

et al. 2020

IJFMT

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Introduction: Exposure of toluene can cause a decrease in glutathione concentration, increase in malondialdehyde and neurotoxic symptoms. The safe duration of toluene in hours/day for each person can vary. The purpose of this study is to determine the relationship between the safe duration of toluene (hours/ day) with the concentration of glutathione, malondialdehyde and neurotoxic symptoms in Osowilangun shoe home industry workers.Methods: This research was observational with quantitative approach and cross-sectional design. The sampling technique used was accidental sampling with 25 respondents. The variables studied were safe toluene duration (hours/day), glutathione concentration, malondialdehyde concentration, and neurotoxic symptoms. Data were analyzed using Pearson and Phi correlation. Result:The average of safe duration was 1,489 hours/day, glutathione concentration was 58,349 µg/L, and malondialdehyde was 7,847 MU. As many as 11 out of 14 workers experienced neurotoxic symptoms. The relationship between safe duration (hours/day) with glutathione concentration (r=0.139) and malondialdehyde (r=-0.146) was very weak. While, the relationship between safe duration (hours/day) and neurotoxic symptoms was weak (φ=-0.223). Conclusion:The relationship between safe duration in hours/day with glutathione concentration and malondialdehyde was very weak, while relationship with neurotoxic symptoms was weak.

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“…Moreover, CIT‐induced downregulation of critical plasticity genes may also reflect altered mPFC physiology as two acute exposures to toluene (10 500 ppm) in adolescent but not adult rats alter the intrinsic excitability of mPFC neurons projecting to the NAc 6 . Thus, future studies that focus on the consequences of adolescent CIT exposure upon mPFC neurophysiology and the responsivity of the mPFC transcriptome to subsequent stimuli (e.g., additional toluene exposure or learning) are warranted, particularly in light of recent findings that N ‐methyl‐ d ‐aspartate (NMDA)‐mediated plasticity within the mPFC may underlie the cognitive deficits associated with CIT 43 . Moreover, future studies should functionally validate the role of identified candidate genes in CIT‐induced cognitive deficits employing viral‐mediated gene knock‐down or overexpression within the mPFC, although this is beyond the scope of the present study.…”

Section: Discussionmentioning

confidence: 99%

Adolescent chronic intermittent toluene inhalation dynamically regulates the transcriptome and neuronal methylome within the rat medial prefrontal cortex

et al. 2020

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Inhalants containing the volatile solvent toluene are misused to induce euphoria or intoxication. Inhalant abuse is most common during adolescence and can result in cognitive impairments during an important maturational period. Despite evidence suggesting that epigenetic modifications may underpin the cognitive effects of inhalants, no studies to date have thoroughly investigated toluene‐induced regulation of the transcriptome or discrete epigenetic modifications within the brain. To address this, we investigated effects of adolescent chronic intermittent toluene (CIT) inhalation on gene expression and DNA methylation profiles within the rat medial prefrontal cortex (mPFC), which undergoes maturation throughout adolescence and has been implicated in toluene‐induced cognitive deficits. Employing both RNA‐seq and genome‐wide Methyl CpG Binding Domain (MBD) Ultra‐seq analysis, we demonstrate that adolescent CIT inhalation (10 000 ppm for 1 h/day, 3 days/week for 4 weeks) induces both transient and persistent changes to the transcriptome and DNA methylome within the rat mPFC for at least 2 weeks following toluene exposure. We demonstrate for the first time that adolescent CIT exposure results in dynamic regulation of the mPFC transcriptome likely relating to acute inflammatory responses and persistent deficits in synaptic plasticity. These adaptations may contribute to the cognitive deficits associated with chronic toluene exposure and provide novel molecular targets for preventing long‐term neurophysiological abnormalities following chronic toluene inhalation.

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Repeated toluene exposure alters the synaptic transmission of layer 5 medial prefrontal cortex

Cited by 11 publications

References 22 publications

The effect of adolescent inhalant abuse on energy balance and growth

The effect of adolescent inhalant abuse on energy balance and growth

Correlation of Toluene Safe Duration (Hours/Day) and Glutathione Concentration, Malondialdehyde and Neurotoxic Symptoms in Osowilangun Shoe Home Industry Workers

Adolescent chronic intermittent toluene inhalation dynamically regulates the transcriptome and neuronal methylome within the rat medial prefrontal cortex

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