Repeated treatment with antidepressant drugs increases the behavioural response to apomorphine

Abstract

The effect of repeated treatment (twice a day for 14 days) with antidepressant drugs (AD): imipramine, amitriptyline, zimelidine, citalopram and mianserin on the behavioural response to apomorphine in rats (open field test) was investigated. AD studied, given alone in a single dose or repeatedly, do not change the rats behaviour. A repeated but not single-dose treatment with AD facilitates the behaviour stimulation induced by apomorphine. This facilitation is observed 2 hours after the last dose of imipramine, zimelidine, citalopram and mianserin but 72 hours after the last dose of amitriptyline. The results presented suggest that the AD given repeatedly are able to increase the responsiveness of the brain DA system, probably the mesolimbic one.

Antidepressant drugs increase the locomotor hyperactivity induced by MK-801 in rats

“…Our previous studies showed that various AD which neither have affinity for dopamine receptors nor produce symptoms of dopaminergic stimulation, potentiate behavioural effects induced by dopaminomimetics, such as D-amphetamine, nomifensine and apomorphine (Maj, 1984(Maj, , 1986Maj et al, 1984Maj et al, , 1985Maj et al, , 1986Maj et al, , 1987. Similar results for some AD have also been described by other authors (Spyraki and Fibiger, 1981;Martin-Iverson et al, 1983;Arnt et al, 1984;Ptalnik and Kostowski, 1987;De Montis et al, 1989, 1990a.…”

Effects of antidepressant drugs on the dopamine D2/D3 receptors in the rat brain differentiated by agonist and antagonist binding – an autoradiographic analysis

“…Repeated administrations of antidepressant drugs have been found to potentiate the locomotor stimulant effects of dopamine D 2 /D 3 agonists. These effects were apparent following systemic administration ; Maj and Wędzony 1988;Maj et al 1984Maj et al , 1989Martin-Iverson et al 1983;Płaźnik and Kostowski 1987;Willner and Montgomery 1981) or direct injection of D 2 /D 3 agonists into the nucleus accumbens Wędzony 1985,1988;Maj et al 1987). It is noteworthy that stereotypy, a behavioral effect induced by D-amphetamine and apomorphine, was not increased by repeated treatment of antidepressant drugs (Delini-Stula and Vassout 1979;Serra et al 1990;Spyraki and Fibiger 1981).…”

D1 dopamine receptor binding in mood disorders measured by positron emission tomography

“…Recent studies have particularly focused on the possible role of altered dopamine receptor activities in mood disorders. Chronic administration of different antidepressants to rats results in potentiation of the behavioral responses to apomorphine and d-amphetamine, which are considered to be mediated by activation of postsynaptic Dz dopamine receptors (Spyraki and Fibiger 1981;Maj et al 1984Maj et al , 1987Serra et al 1990). In contrast to behavioral * Preliminary results of this study were presented at the 17th Congress of Collegium Internationale Neuro-Psychopharmacologicum, Kyoto International Conference Hall, Kyoto, Japan, September 10-14, 1990 Offprint requests to."…”