Repeated ultrasound-guided intra-articular injections of 40mg of Hyalgan® may be useful in symptomatic relief of hip osteoarthritis

Migliore, Alberto; Tormenta, Sandro; Massafra, Umberto; Carloni, Emilia; Padalino, C.; Iannessi, F.; Alimonti, Andrea; Martin, Luis Severino Martin; Granata, M.

doi:10.1016/j.joca.2005.08.001

Cited by 25 publications

(15 citation statements)

References 5 publications

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“…The present study demonstrates the safety and efficacy of Jointe x® for the treatment of hip OA injected under ultrasound-controlled procedure (13) . The data from this cohort study are simi lar to our previous studies (12)(13)(14)(15), giving additional evidence that viscosupplementation may be useful in treating hipOA.…”

Section: Discussionsupporting

confidence: 78%

“…For such reasons, it has been suggested to perform intra-articular injection of the hip under radiological or ultrasound control. Although several ultrasound guidance techniques were available (16)(17)(18), we developed a personal one using an anterosuperior approach (12)(13)(14)(15). We had reported several observational trials to assess viscosupplementation for the treatment of hip OA with a progressive number of patients and longer follow-up using different HA products.…”

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confidence: 99%

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Efficacy and Safety Profile of Intra-Articular Administration of Jointex® in Patients Suffering from Symptomatic Hip Osteoarthritis: An Open, Prospective Study with a 12-Month Follow-up

et al. 2011

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Hip osteoarthritis represents a statistically relevant problem in clinical practice; previous reports showed different efficacy and safety profiles for intra-articular use of hyaluronic acid in hip osteoarthritis-affected patients, and in this sense, to add evidence to this topic, data regarding safety and efficacy of ultrasound-guided viscosupplementation are reported in order to establish whether such a therapeutic tool may represent a valid option. This study investigates the safety and efficacy profiles of ultrasound-guided intra-articular injections of Jointex® in hip osteoarthritis affected patients. This is a prospective multicentric study carried out in public hospitals. Adult outpatients suffering from symptomatic hip OA (Kellgren and Lawrence Grade 2, 3 or 4) were injected with one syringe of 4 ml (2 vials) of Jolntex" under ultrasound guidance, repeated after six months; when clinically necessary an adjunctive injection was performed. Patients' characteristics, such as gender, age, weight, height and BMI, smoking habit, unilateral or bilateral hip OA, radiological grade for hip OA following KellgrenLawrence grading and duration of disease, were evaluated. Patients were assessed at baseline and at every control visit and injection time for Lequesne index as primary endpoint, pain (evaluated by VAS) and NSAID consumption (number of days patients assumed NSAID in the last month) both as secondary endpoint. A total of 180 patients entered the study, all of whom received at least one IA US-guided injection of .lointex" into the hip joint. A total of 36 drop outs were registered, and both distribution and causes of drop out were recorded. A total of 389 injections were carried out, as 18 patients were affected by bilateral hip OA and 7 patients affected by monolateral hip OA required one more injection for symptomatic relief in respect to other patients. Scores obtained for primary as well as secondary study endpoints reached statistical significance when compared with scores obtained at baseline visit. Lequesne index mean scores obtained at each control visit, when compared with baseline mean value, were significantly different (p

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Section: Discussionsupporting

confidence: 78%

mentioning

confidence: 99%

Efficacy and Safety Profile of Intra-Articular Administration of Jointex® in Patients Suffering from Symptomatic Hip Osteoarthritis: An Open, Prospective Study with a 12-Month Follow-up

et al. 2011

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“…From the papers retrieved in the search the following data were extracted: sample size, inclusion / exclusion criteria, treatment procedures, evaluation methods, clinical results and follow-up duration. The case series, published by Migliore et al (16)(17)(18)(19)(20)(21) and Van den Bekerom et al (22,23), at different times, were considered cumulative. Methodological quality of included studies was assessed by assigning Levels of Evidence as previously defined by the Centre for Evidence Based Medicine (CEBM) (24).…”

Section: Methods Of Literature Analysismentioning

confidence: 99%

Viscosupplementation with Hyaluronic Acid in Hip Osteoarthritis (a review)

Abate¹,

Pelotti²,

Amicis³

et al. 2008

Upsala Journal of Medical Sciences

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Background: Viscosupplementation (VS) with hyaluronic acid (HA) is largely used for knee osteoarthritis therapy, but the evidences for its usefulness in hip osteoarthritis (OA) are limited. Methods: In this review, an extensive search of published trials on VS in hip OA was performed. From the selected papers the following data were extracted: sample size, inclusion / exclusion criteria, treatment procedures, evaluation methods, follow-up duration and clinical outcomes. Results: The level of evidence was low in quite all the trials (no placebo controlled groups). A reduction of pain and an improvement of function after 3 months, persistent in the long term (12 -18 months), was observed. Patients with mild morphological alterations responded better to therapy. Side effects were negligible, and were limited to pain and a sensation of heaviness in the injection site. No clear differences among Low (LMW) and High Molecular Weight (HMW) HA preparations were found in the clinical outcomes. However, for HMW-HA preparations, a lower number of injections was, in general, necessary in order to reach the therapeutic effect. Conclusions: Despite the initial promising results, some questions still remain open : 1) the characteristics of responders must be more precisely defined; 2) the treatment schedules, at present mainly based on the individual clinical experience, need a proper and accepted standardization. Finally, larger and placebo controlled trials are necessary to confirm the efficacy of VS in hip OA.

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“…The need for concomitant analgesia like NSAIDS, opiods etc and modalities like ultrasound therapy, short wave diathermy etc is reduced. There is increasing interest in the use of HAs for OA at sites other than the knee including shoulder and hip OA [34,35].…”

Section: Discussionmentioning

confidence: 99%

Efficacy, Tolerability and Adverse Events of Single-Shot Intra-Articular Hyaluronic Acid Injection in Knee Osteoarthritis

Hussain¹,

Rather²,

Qayoom³

2014

J Trauma Treat

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Repeated ultrasound-guided intra-articular injections of 40mg of Hyalgan® may be useful in symptomatic relief of hip osteoarthritis

Cited by 25 publications

References 5 publications

Efficacy and Safety Profile of Intra-Articular Administration of Jointex® in Patients Suffering from Symptomatic Hip Osteoarthritis: An Open, Prospective Study with a 12-Month Follow-up

Efficacy and Safety Profile of Intra-Articular Administration of Jointex® in Patients Suffering from Symptomatic Hip Osteoarthritis: An Open, Prospective Study with a 12-Month Follow-up

Viscosupplementation with Hyaluronic Acid in Hip Osteoarthritis (a review)

Efficacy, Tolerability and Adverse Events of Single-Shot Intra-Articular Hyaluronic Acid Injection in Knee Osteoarthritis

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