Repellent and adulticide efficacy of a combination containing 10% imidacloprid and 50% permethrin against Aedes aegypti mosquitoes on dogs

Tiawsirisup, Sonthaya; Nithiuthai, Suwannee; Kaewthamasorn, Morakot

doi:10.1007/s00436-007-0508-9

Cited by 18 publications

(14 citation statements)

References 9 publications

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“…The repellency of the fipronil and permethrin combination against A. aegypti was similar to, or higher than, previously reported for other commercial permethrin-containing products [ 9 , 15 , 16 ]. The repellency of a single-active 65% permethrin product ranged from 78.0% to 89.9% until Day 21 and then declined to 61.9% on Day 28; for a combination of permethrin and imidacloprid, repellency ranged from 84.9% to 94.1% through Day 21 and then declined to 50.4% on Day 28; and for a combination of permethrin, dinotefuran and pyriproxyfen repellency ranged from 91.5% to 94.0% through Day 21 and remained at 87.0% on Day 28 [ 9 , 15 , 16 ]. The excellent duration of effect of the new combination may relate to the product’s formulation, the combination of the effects of permethrin with those of fipronil, or other factors.…”

Section: Discussionsupporting

confidence: 86%

“…Permethrin has been applied in different formulations for the control of ectoparasites on both companion and production animals, as well as humans. Both single-active formulations, as well as combination products, have been shown to effectively control mosquitoes [ 9 , 15 , 16 ]. Fipronil, a phenylpyrazole, has both insecticidal and acaricidal activity.…”

Section: Introductionmentioning

confidence: 99%

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Repellent and insecticidal efficacy of a new combination of fipronil and permethrin against three mosquito species (Aedes albopictus, Aedes aegypti and Culex pipiens) on dogs

Fankhauser¹,

Dumont

Hunter³

et al. 2015

Parasites Vectors

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BackgroundThree laboratory studies were conducted to assess the repellent and insecticidal efficacy of a combination of fipronil and permethrin (Frontline Tri- Act®/Frontect®) against three mosquito species (Aedes albopictus, Aedes aegypti and Culex pipiens) on dogs.MethodsIn each study, 16 healthy adult dogs were allocated to two groups. Eight dogs were treated with the new topical spot-on combination of fipronil and permethrin on Day 0 and the other eight dogs served as untreated controls. Each dog was exposed to mosquitoes on Days 1, 7, 14, 21 and 28 (and also on Day 35 in the A. aegypti study). After a 1-h exposure period, all mosquitoes were counted and categorized as live or dead and fed or non-fed. Live mosquitoes were kept in an insectary and observed for mortality counts 4, 24 and 48 h post-exposure (PE) for Aedes spp. and 24 and 48 h PE for C. pipiens. Repellency and insecticidal efficacies were defined as the percent reduction in the number of fed and live mosquitoes, respectively, in the treated group as compared to the untreated control group.ResultsRepellency against A. albopictus was ≥93.4% through Day 21 and 86.9% on Day 28. It was ≥91.0% through Day 35 against A. aegypti and ≥90.4% through Day 28 against C. pipiens. Insecticidal efficacy against A. albopictus was ≥97.1% at 24 h PE from Day 7 to Day 28. It was ≥98.0% for the first 3 weeks and still 75.7% on Day 35 against A. aegypti at 24 h PE. For C. pipiens, insecticidal efficacy ranged from 93.8% (Day 7) to 30.9% (Day 28) at 48 h PE.ConclusionsA single topical administration of the combination of fipronil and permethrin provides repellency against mosquitoes on dogs for at least 4 weeks. The product may therefore significantly reduce the potential for the transmission of vector-borne pathogens through the inhibition of mosquito feeding, as well as the discomfort associated with mosquito bites. Moreover, mosquito mortality was induced by contact with the treated dogs, which could aid in the control of mosquitoes, and hence the control of mosquito-borne diseases, in the local vicinity of treated dogs.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Repellent and insecticidal efficacy of a new combination of fipronil and permethrin against three mosquito species (Aedes albopictus, Aedes aegypti and Culex pipiens) on dogs

Fankhauser¹,

Dumont

Hunter³

et al. 2015

Parasites Vectors

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“…In veterinary medicine, target species such as dogs are often involved in parasiticide testing without preliminary efficacy assessments in animal models (Tiawsirisup et al, 2007;Machida et al, 2008;Bonneau et al, 2010;Franc et al, 2012;Molina et al, 2012;Dumont et al, 2015aDumont et al, , 2015bVarloud & Hodgkins, 2015). However, these models can provide preliminary and complementary information that may be useful in further testing on the targeted animal.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, additive effects were observed in numerous studies in which permethrin was administered in combination with other insecticides. In the same species of mosquito, a formulation containing 10% imidacloprid and 50% permethrin provided repellency that ranged from 84.9 to 94.1% until day 21 and then declined to 50.4% at 28 days after treatment (Tiawsirisup et al, 2007). In a recent combination, 6.7% fipronil and 50.4% permethrin continued to have high repellency against S. aegypti (96.1%) and Culex pipiens (Diptera: Culicidae) (90.4%) for 28 days post-treatment.…”

Section: Discussionmentioning

confidence: 99%

Anti‐feeding and insecticidal efficacy of a topical administration of dinotefuran–pyriproxyfen–permethrin spot‐on (Vectra® 3D) on mice against Stegomyia albopicta (= Aedes albopictus)

Tahir

Davoust

Alméras

et al. 2017

Medical Vet Entomology

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Abstract. An ectoparasiticide combining three active ingredients [dinotefuran, permethrin and pyriproxyfen (DPP)] was used in mice in an experiment designed to evaluate its anti-feeding and insecticidal efficacy against Stegomyia albopicta (= Aedes albopictus) (Diptera: Culicidae) mosquitoes. Twenty-two adult mice were randomly allocated into two groups consisting of an untreated control group and a DPP-treated group. Mice were exposed individually for 1 h to a mean ± standard deviation of 27 ± 2 starved female mosquitoes on days 1, 7, 14, 21 and 28 post-treatment. At the end of the exposure (1 h), mosquitoes were assessed for immediate survival and engorgement status. Additionally, live mosquitoes in both groups were incubated separately and observed for mortality at 24 h after the end of the exposure. The anti-feeding efficacy of DPP after the 1-h exposure period was 99.2, 100, 98.0, 89.3 and 87.4% at 1, 7, 14, 21 and 28 days, respectively. Levels of insecticidal efficacy evaluated at 1 h and 24 h after exposure on days 1, 7, 14, 21 and 28 were 36.7, 28.9, 30.8, 23.1 and 11.9%, and 68.4, 45.0, 43.3, 37.9 and 19.9%, respectively. Based on the mouse model, the present study demonstrates that the DPP combination has significant anti-feeding and insecticidal efficacy against S. albopicta for at least 4 weeks.

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“…A spot-type insecticide solution containing both imidacloprid and permethrin (I-P solution) is expected to show, not only an insecticidal but also a bloodsucking repellent efficacies against mosquito biting, consequently, preventing Dirofilaria immitis infection. Only a few reports, however, have studied on the bloodsucking inhibitory efficacy of imidacloprid and permethrin against ticks and fleas [1, 4-6, 8], and mosquitoes [1,7].This study was conducted to assess the inhibitory efficacy of I-P solution against bloodsucking by mosquitoes and the preventive efficacy to D. immitis infection by an experimental infection procedure. …”

mentioning

confidence: 99%

Inhibition and Prevention Efficacy against Mosquito Bloodsucking and Dirofilaria immitis Infection by Administration of Topical Insecticide

Hayasaki

Saeki

2009

The Journal of Veterinary Medical Science

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Inhibition and prevention of mosquito bloodsucking by a topical insecticide, and the consequent infection of Dirofilaria immitis were evaluated using a product containing 10% w/w imidacloprid plus 50% w/w permethrin (I-P solution). Nine healthy beagle dogs divided in three groups of 3 dogs each were administered I-P solution on day 3 (group 1), day 36 (group 2) and not administered (group 3 as a control) before starting the experimental infection. The results showed that the mosquito bloodsucking rate was significantly lower, 12.1% in group 1 (p<0.05) and 11.1% in group 2 (p<0.05), than the 40.6% in group 3, meaning that the inhibition rates in groups 1 and 2 against group 3 were 70.2% and 72.7%. The infection rate of experimental D. immitis infection was 33% in group 1, 33% in group 2 and 100% in group 3, meaning that the prevention rates in groups 1 and 2 against group 3 were 67% and 67%. KEY WORDS: canine, Dirofilaria immitis infection, mosquito bloodsucking, topical insecticide. A spot-type insecticide solution containing both imida-cloprid and permethrin (I-P solution) is expected to show, not only an insecticidal but also a bloodsucking repellent efficacies against mosquito biting, consequently, preventing Dirofilaria immitis infection. Only a few reports, however, have studied on the bloodsucking inhibitory efficacy of imi-dacloprid and permethrin against ticks and fleas [1, 4-6, 8], and mosquitoes [1, 7]. This study was conducted to assess the inhibitory efficacy of I-P solution against bloodsucking by mosquitoes and the preventive efficacy to D. immitis infection by an experimental infection procedure. MATERIALS AND METHODS Dogs and experimental groups: Nine healthy female bea-gles were obtained commercially (Nihon Nousan Kogyo Co., Ltd., Tokyo)(weight between 7 and 11 kg, age 9 months) and confirmed to be free of D. immitis infection by the Knott test for microfilaria and a commercial antigen-detecting ELISA kit for adult worms. They were also examined by physical, hematological, blood chemistry and fecal examinations, and confirmed as normal. They were then vaccinated with a commercial mixed vaccine for dog use, housed together in a single kennel with open windows, and fed commercial dog food with free access to clean water throughout the experimental period from June 2006 to Janu-ary 2007, at the laboratory animal facility (School of Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan). Groups 1 and 2 were administered I-P solution on day 3 and day 36 before the experimental D. immitis infection, respectively , and group 3 served as a control of the experimental infection without administration of I-P solution. I-P solution: The solution contains a combination of 10% imidacloprid (100 mg/ml) and 50% permethrin (500 mg/ml) (Fortreon TM , Bayer Yakuhin Co., Ltd., Tokyo) and the standard dose is to drop 0.1 ml/kg of the solution on the inter-scapular portion of the back. According to the package insertion, the solution penetrates the sebum and spreads over the skin surface throughout the body wi...

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Repellent and adulticide efficacy of a combination containing 10% imidacloprid and 50% permethrin against Aedes aegypti mosquitoes on dogs

Cited by 18 publications

References 9 publications

Repellent and insecticidal efficacy of a new combination of fipronil and permethrin against three mosquito species (Aedes albopictus, Aedes aegypti and Culex pipiens) on dogs

Repellent and insecticidal efficacy of a new combination of fipronil and permethrin against three mosquito species (Aedes albopictus, Aedes aegypti and Culex pipiens) on dogs

Anti‐feeding and insecticidal efficacy of a topical administration of dinotefuran–pyriproxyfen–permethrin spot‐on (Vectra® 3D) on mice against Stegomyia albopicta (= Aedes albopictus)

Inhibition and Prevention Efficacy against Mosquito Bloodsucking and Dirofilaria immitis Infection by Administration of Topical Insecticide

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