Repercusión clínica de la alfa-talasemia en nuestro medio. Impacto del  screening  neonatal

Aristizábal, Ana M.; Merino, Sonia; Catediano, E.; Sasieta, M.; Aragües, P.; Navajas, Aurora

doi:10.1016/j.anpedi.2014.10.014

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…In most cases, this can result in mild anaemia in an individual, which can also be mistaken for an iron deficiency (6). However, individuals who inherit this gene from their parents need to be very cautious when they have children of their own as the chances of their children inheriting more severe forms of thalassemia, increase significantly (7). The three types of thalassemia minor include alpha plus thalassemia trait which involves one of the four alpha genes to be missing, alpha zero thalassemia trait which involves two missing alpha haemoglobin genes, and beta thalassemia trait which involves the absence of one out of two beta haemoglobin genes (2, 3, 5).…”

Section: Introductionmentioning

confidence: 99%

“…Alpha thalassemia major, however, can be identified during the pregnancy since Haemoglobin production in the foetus does not start. In such cases, efforts can only be directed at taking the necessary precautions to avoid maternal complications that range from toxaemia to premature delivery and higher chances of delivery by caesarean sections (5, 7). The best option while dealing with thalassemia is to ensure that it is prevented, which can be done by checking both parents for the presence of any gene mutations before the couple decides to have a child (5, 8).…”

Section: Introductionmentioning

confidence: 99%

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Thalassemia review: features, dental considerations and management

Helmi¹,

Bashir²,

Shireen³

et al. 2017

Electron physician

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Thalassemia is a genetic disorder that involves abnormal haemoglobin formation. The two main categories of thalassemia are alpha and beta thalassemia that are then divided into further subcategories. While some mild forms of thalassemia might even go unnoticed and only cause mild anaemia and iron deficiency problems in patients, other more severe forms of thalassemia can even result in death. Individuals with thalassemia can get treatment according to the level of severity of their condition. The main oral manifestations of thalassemia are Class II malocclusion, maxillary protrusion, high caries index, severe gingivitis. Any dental surgical procedure for such patients should be done under antibiotic cover and immediately after transfusion. Caution should be exercised in thalassemia patients due to complications related to compromised immunity and cardiovascular issues. Multidisciplinary approach involving dental surgeon, haematologist and orthodontist is the best advised approach.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thalassemia review: features, dental considerations and management

Helmi¹,

Bashir²,

Shireen³

et al. 2017

Electron physician

View full text Add to dashboard Cite

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Congenital Hematological and Metabolic Disorders Causing Intrinsic Discoloration of Pediatric Dentition at Pre-Eruptive Stage

Ghoshal,

Singh

2024

DJIGIMS

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The current review assesses the literature and depicts the hematological and metabolic diseases of newborns resulting in intrinsic stains of primary dentition. The appearance of dentition is an esthetic concern to the child as well as to the caregivers. The correct diagnosis claims prime importance to the dentist as it has profound value in deciding the appropriate treatment protocol and describing it to the patient. The review describes the hematological and metabolic diseases of newborns which can affect the color of normal pediatric dentition. Erythroblastosis fetalis, icterus gravis neonatorum, congenital erythropoietic porphyria, thalassemia, sickle cell anemia, and alkaptonuria are found to have a definite impact on the intrinsic discoloration of deciduous teeth. The article is an overview of those congenital hematological and metabolic disorders and their direct and indirect effects on primary dentition at the pre-eruptive stage resulting in discoloration.

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Repercusión clínica de la alfa-talasemia en nuestro medio. Impacto del screening neonatal

Cited by 2 publications

References 5 publications

Thalassemia review: features, dental considerations and management

Thalassemia review: features, dental considerations and management

Congenital Hematological and Metabolic Disorders Causing Intrinsic Discoloration of Pediatric Dentition at Pre-Eruptive Stage

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