Repercussions of Breastfeeding by Diabetic Women for Breast Cancer

Abstract

Diabetes represents a serious health problem. In the diabetic state, alterations in metabolism, increased susceptibility to infections and immunological changes occur. The suppression of the immune response has been identified as a relevant factor that contributes to the increase in the rate of infections in these patients. At the same time, breast cancer is the most frequent malignant tumor in women. The molecular and cellular mechanisms underlying cancer development have revealed that immune cells functionally regulate epithelial cancer development and progression. Breastfeeding has been hypothesized to reduce the risk of breast cancer. However, early systematic reviews have not yielded consistent findings for this association. The demand for human milk is increasing due to the promotion and consumer acceptance of the health benefits of consuming a natural product rich in bioactive components. However, due to changes in glucose metabolism, the components of the milk from diabetic women are modified depending on the time of evaluation. In this literature review, we summarize important new findings revealing the paradoxical role of breastfeeding in preventing the onset of breast cancer in diabetic mothers. We hypothesized that the milk component production in diabetic mothers is affected by changes in glucose metabolism. Therefore, adequate maternal glycemic control and an adequate duration of breastfeeding for diabetic mothers are crucial to ensure that the immunity components are able to confer protection against breast cancer.

Intracellular calcium is a target of modulation of apoptosis in MCF-7 cells in the presence of IgA adsorbed to polyethylene glycol

“…Clinical and epidemiological studies have shown that breastfeeding has a protective effect on breast cancer risk. 1 – 3 Accumulating evidence has suggested that human breast milk may confer long-term benefits, such as reduced risks of certain autoimmune diseases, inflammatory bowel disease, and certain malignancies. Some studies have also indicated that a reduced incidence of breast cancer is the most well-documented long-term effect of breastfeeding on mothers; 4 however, the degree to which some of these health benefits may be realized depends on the breastfeeding duration, breastfeeding frequency, breastfeeding exclusivity, and other personal factors.…”

“…Some studies have also indicated that a reduced incidence of breast cancer is the most well-documented long-term effect of breastfeeding on mothers; 4 however, the degree to which some of these health benefits may be realized depends on the breastfeeding duration, breastfeeding frequency, breastfeeding exclusivity, and other personal factors. 3 …”

Influence of Propofol, Isoflurane and Enflurance on Levels of Serum Interleukin-8 and Interleukin-10 in Cancer Patients

“…Immunological dysfunction, which is common in cancer patients and can be aggravated by surgery-induced traumatic inflammation, becomes one of the important risk factors for cancer (Franca et al, 2013;Yu et al, 2014). With the development of molecular biology, cytokine has received more and more attentions due to its critical role in traumatic inflammatory responses.…”

Nanodoses of melatonin induces apoptosis on human breast cancer cells co-cultured with colostrum cells

“…Clinical and experimental evidence has supported the hypothesis that colostrum is important in the protection against breast cancer [1] and can reduce the risk of disease in women who breastfeed [2,3]. Colostrum contains soluble and cellular components, such as lipids, carbohydrates, cytokynes, viable leukocytes [particularly macrophages] [4], and hormones, which are important for immune defense [5] and exhibit a circadian rhythm [6].…”