Repercussions of intermittent fasting on the intestinal microbiota community and body composition: a systematic review

Abstract

Context Several therapies have been tested for combating weight gain and obesity-related metabolic diseases, and among these therapies, intermittent fasting (IF) has gained a great deal of interest. Objective The aim of this study was to provide the reader with a current survey of IF protocols and an understanding of the outcomes found to date in terms of the profile of the intestinal microbiota (IM) in obese organisms. Data Sources Data were obtained from 4 databases: PubMed, SCOPUS, LILACs, and Web of Science. Data Extraction Data from studies relating IF protocols to the microbiota and weight loss were extracted using a protocol in START program. Data Analysis Of the 82 original articles identified from the databases, 35 were eliminated due to duplication, and 32 were excluded due to not meeting the inclusion criteria. Two additional articles found in a new search were added, yielding a total of 17 studies to be included in this review. Among the protocols, alternate-day fasting (ADF) and time-restricted feeding (TRF) were the most common, and they were shown to have different mechanisms of metabolic signaling. TRF influences weight control and biochemical parameters by regulating the circadian system, and improving satiety control systems by acting on leptin secretion. On the other hand, ADF leads to a reduction of ±75% of all energy consumption regardless of dietary composition in addition to promoting hormonal adjustments that promote weight control. Furthermore, both protocols showed the ability to remodel the IM by changing the Firmicutes/Bacteroidetes ratio and increasing the abundance of strains such as Lactobacillus spp. and Akkermansia m. that have a protective effect on metabolism against the effects of weight gain. Conclusion In short, the ADF and TRF protocols have a positive effect on the remodeling of the IM and can possibly be used to control body adiposity, improve insulin sensitivity, and achieve other obesity-related metabolic changes.

The Effects of Time-Restricted Eating on Metabolism and Gut Microbiota: A Real-Life Study

“…Owing to the small number of studied patients, the medium/high risk of bias of the available studies, and the current low level of evidence [54], further studies, assessing the mechanistic and functional aspects of microbiota-host relationships, are needed to better define the impact of TRE on human-gut microbiota.…”

Intermittent Fasting to the Eye: A New Dimension Involved in Physiological and Pathological Changes

“…Intestinal microecology is a new aspect of the metabolic regulatory role of IF, and several studies have shown the potential of IF to alter flora composition. Pinto et al ( 100 ) recently published a systematic review on the role of IF in remodeling the gut microbiota in humans and rats/mice. In this study, the authors found that both alternate-day fasting and time-restricted fasting regimens altered the ratio of intestinal flora, mainly the Firmicutes/Bacteroidetes ratio and Lactobacillus spp abundance.…”

Pathogenic Mechanisms of the Severe Acute Respiratory Syndrome Coronavirus 2 and Potential Direct and Indirect Counteractions by Intermittent Fasting

“…The gut microbiome, including the appendix that is now recognized as a non-vestigial well that maintains the microbiome [ 72 ], is recognized today for substantial influences on human health [ 30 , 31 , 32 , 73 , 74 , 75 , 76 ]. The microbiome impacts human health, both in the prevention of or acceleration of chronic diseases and in limiting or enhancing infectious diseases [ 16 , 30 , 31 , 32 , 73 , 74 , 75 , 76 ]. This includes the potential for acute infections in the intestine or in the appendix to radically alter organ-level health [ 73 , 74 , 75 , 76 ].…”

“…The microbiome impacts human health, both in the prevention of or acceleration of chronic diseases and in limiting or enhancing infectious diseases [ 16 , 30 , 31 , 32 , 73 , 74 , 75 , 76 ]. This includes the potential for acute infections in the intestine or in the appendix to radically alter organ-level health [ 73 , 74 , 75 , 76 ]. SARS-CoV-2 may be one of such infections, inducing gut microbiome dysbiosis that leads to enhanced proliferation of pathogenic microbial species, including anti-microbial resistant strains, and to the movement of harmful secondary pathogens into the bloodstream from the gut [ 30 , 73 ].…”