Repercussões sistêmicas da icterícia obstrutiva

Rizzo, C.; Silva, Orlando de Castro e; Sankarankutty, Ajith Kumar; Menegazzo, Luiz Alfredo G.; Granato, Rubens Gutierrez

doi:10.11606/issn.2176-7262.v30i2p173-182

Cited by 3 publications

(6 citation statements)

References 4 publications

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“…The enlargement of livers in TAA treated rats signified hepatic lesions and liver injury associated with the toxicological effects of TAA. Studies that relate to liver weight change are complex ( Rizzo et al, 1997 ). Many factors are involved in the pathogenesis of this interaction, including control of feeding behavior, fat storage mechanisms, regulation of energy intake and energy expenditure, as well as hormonal, genetic and psychological influences ( Lissner, 1993 ).…”

Section: Discussionmentioning

confidence: 99%

Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats

Al-Attar

Al-Rethea

2017

Saudi Journal of Biological Sciences

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The current study was designed to investigate the possible protective effect of omega-3 fatty acids from fish oil on hepatic fibrosis induced by thioacetamide (TAA) in male rats. The experimental animals were divided into four groups. The first group was received saline solution and served as control. The second group was given 250 mg/kg body weight of TAA. The third group was treated with omega-3 fatty acids and TAA. The fourth group was given saline solution and supplemented with omega-3 fatty acids. Treatment of rats with TAA for three and six weeks resulted in a significant decrease in body weight gain, while the value of liver/body weight ratio was statistically increased. Furthermore, the levels of serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma glutamyl transferase and total bilirubin were significantly increased. After three weeks of exposure to only TAA, liver sections showed an abnormal morphology characterized by noticeable fibrosis with the extracellular matrix collagen contents and damage of liver cells' structure. Liver sections from rats treated with only TAA for six weeks revealed an obvious increase in extracellular matrix collagen content and bridging fibrosis. Treating TAA-intoxicated rats with omega-3 fatty acids significantly attenuated the severe physiological and histopathological changes. Finally, the present investigation suggests that omega-3 fatty acids could act against hepatic fibrosis induced by TAA due to its antioxidant properties, thus supporting its use in hepatic fibrosis therapy.

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Section: Discussionmentioning

confidence: 99%

Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats

Al-Attar

Al-Rethea

2017

Saudi Journal of Biological Sciences

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“…In such cases, the rate of progression of the disease and its prognosis could be determined by the intrinsic characteristics of the individual, such as age, nutrition and immune status [1][2][3][4][5] . In the present work, the fact that some animals showed higher levels of bilirubin could also justify this hypothesis.…”

Section: Groupsmentioning

confidence: 99%

“…The reduction in body weight of both males and females after biliopancreatic duct ligation may be directly related to hyperbilirubinemia. It is known that jaundiced patients with advanced liver disease lose weight not only due to the disease itself, but also by low food intake [1][2][3][4][5] . In the literature, there are reports of weight loss Body weight all the groups (g average), assessed on day 1 (initial) and in the 7th week (final) of the experiment.…”

Section: Groupsmentioning

confidence: 99%

“…Its organic repercussions may be followed by serious sequelae 1 . While there are discussions about possible effects of hyperbilirubinemia in body metabolism, there are still studies that examine the impact of liver disease on body weight [2][3][4][5] . Zaina et al, In 2004, studied 219 candidates to liver transplant of both genders and observed that patients with cholestatic diseases were more malnourished when compared to patients with non-cholestatic diseases 6 .…”

Section: Introduction Introduction Introduction Introductionmentioning

confidence: 99%

“…Other authors also suggested interaction between hepatic metabolism and body mass [7][8][9] . Studies that relate to liver weight change are complex 3 . Many factors are involved in the pathogenesis of this interaction, including control of feeding behavior, fat storage mechanisms, regulation of energy intake and energy expenditure, as well as hormonal, genetic and psychological influences 10 .…”

Section: Introduction Introduction Introduction Introductionmentioning

confidence: 99%

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Influência da icterícia colestática na variação ponderal em modelo experimental

Vasconcellos¹,

Alberti²,

Romeiro³

et al. 2012

Rev. Col. Bras. Cir.

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OBJETIVO: Avaliar a influência da icterícia colestática na variação ponderal. MÉTODOS: Foram utilizados 64 ratos adultos, distribuídos em seis grupos: F1 (n=6) - fêmeas normais, F2 (n=6) - fêmeas laparotomizadas, F3 (n=20) - fêmeas ictéricas, M1 (n=6) - machos normais, M2 (n=6) - machos laparotomizados, M3 (n=20) - machos ictéricos. A icterícia foi obtida com ligadura e secção do ducto biliopancreático. Os pesos dos animais foram registrados semanalmente, durante sete semanas. No 14º dia de experimento, dosaram-se as bilirrubinas séricas e os hormônios gonadais. Após a sétima semana, realizou-se estudo histológico do fígado. RESULTADOS: Os animais dos grupos F3 e M3 apresentaram bilirrubinas elevadas e diminuição da massa corpórea, quando comparados com os demais grupos. As diferenças ponderais foram significativas a partir da quarta semana entre as fêmeas e da quinta semana entre os machos. Nos animais ictéricos houve aumento do estradiol e diminuição da progesterona e da testosterona total. Septos de fibroses perivenular e periportal, colangite e hiperplasia de ductos biliares ocorreram no fígado dos animais ictéricos. Nenhum animal apresentou cirrose. CONCLUSÃO: Ocorreu redução do peso corpóreo murino em presença de icterícia colestática em ambos os sexos.

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Hepatoprotective Effects of Biochanin A on Thioacetamide-Induced Liver Cirrhosis in Experimental Rats

Ibrahim,

Alamri,

Juma

et al. 2023

Molecules

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The protective effect of biochanin A (BCA) on the histopathology, immunohistochemistry, and biochemistry of thioacetamide (TAA)-induced liver cirrhosis in vivo was investigated. There was a significant reduction in liver weight and hepatocyte propagation, with much lower cell injury in rat groups treated with BCA (25 mg/kg and 50 mg/kg) following a TAA induction. These groups had significantly lower levels of proliferating cell nuclear antigen (PCNA) and α-smooth muscle actin (α-SMA). The liver homogenates showed increased antioxidant enzyme activity of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), as well as decreased malondialdehyde (MDA) levels. The serum biomarkers associated with liver function, namely alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma glutamyl transaminase (GGT), returned to normal levels, comparable to those observed in both the normal control group and the reference control group. Taken together, the normal microanatomy of hepatocytes, the inhibition of PCNA and α-SMA, improved antioxidant enzymes (SOD, CAT, and GPx), and condensed MDA with repairs of liver biomarkers validated BCA’s hepatoprotective effect.

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Repercussões sistêmicas da icterícia obstrutiva

Cited by 3 publications

References 4 publications

Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats

Chemoprotective effect of omega-3 fatty acids on thioacetamide induced hepatic fibrosis in male rats

Influência da icterícia colestática na variação ponderal em modelo experimental

Hepatoprotective Effects of Biochanin A on Thioacetamide-Induced Liver Cirrhosis in Experimental Rats

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