Repetition Suppression Dissociates Spatial Frames of Reference in Human Saccade Generation

Pelt, Stan van; Toni, Ivan; Diedrichsen, Jörn; Medendorp, W. Pieter

doi:10.1152/jn.00393.2010

Cited by 21 publications

(35 citation statements)

References 69 publications

(75 reference statements)

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“…In comparison, evidence suggests that the FEF and IPS contain a salience map in gaze-centered coordinates that helps guide exploration of the visual environment (16,30,31), consistent with our mapping of the FEF-IPS2 pathway. In addition to using the FEF-IPS2 and SEF-SPL1 pathways to guide eye movements and provide attentional feedback to sensory areas, these pathways may act in concert to remap space across saccades, considering that the relative positions of objects and viewer-centered information help maintain visual stability (32).…”

Section: Discussionsupporting

confidence: 86%

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Functional and structural architecture of the human dorsal frontoparietal attention network

Szczepanski

Pinsk

Douglas³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

190

118

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The dorsal frontoparietal attention network has been subdivided into at least eight areas in humans. However, the circuitry linking these areas and the functions of different circuit paths remain unclear. Using a combination of neuroimaging techniques to map spatial representations in frontoparietal areas, their functional interactions, and structural connections, we demonstrate different pathways across human dorsal frontoparietal cortex for the control of spatial attention. Our results are consistent with these pathways computing object-centered and/or viewer-centered representations of attentional priorities depending on task requirements. Our findings provide an organizing principle for the frontoparietal attention network, where distinct pathways between frontal and parietal regions contribute to multiple spatial representations, enabling flexible selection of behaviorally relevant information.parietal cortex | frontal cortex | DTI | fMRI | connectivity V isual scenes usually contain many different objects, which cannot all be processed simultaneously because of the limited capacity of the visual system. Attention mechanisms are thus needed to select the most behaviorally relevant information for further processing. Previous studies have demonstrated activations over large portions of dorsal frontoparietal cortex during a variety of selective attention tasks (1, 2). In humans, these regions include intraparietal sulcus areas 1-5 (IPS1-IPS5) and superior parietal lobule area 1 (SPL1) in posterior parietal cortex (PPC), defined by spatial topographic mapping (3, 4), as well as the frontal eye field (FEF) and the putative human supplementary eye field (SEF) in frontal cortex (Fig. S1). Although these areas are commonly conceptualized as a frontoparietal attention network, the circuitry linking areas, the functions of different circuit paths, and the different roles of individual areas in representing attentional priorities remain unclear.Because everyday actions rely on representations of attentional priorities in egocentric (gaze-centered, body-centered) and allocentric (object-centered, world-centered) spatial reference frames (5-9)-for example, to pick up a coffee cup, we must know where the cup is relative to our body, as well as where the handle is relative to the cup-we need to flexibly specify and read out attentional priorities in different reference frames. However, human neuroimaging studies have largely focused on gaze-centered representations and have been relatively unsuccessful in finding representations in other spatial reference frames, perhaps because they have focused on visual cortex (e.g., refs. 10 and 11). In frontoparietal cortex, the topographic organization of IPS1-5, SPL1, and FEF suggests that they contain spatial representations at least in egocentric reference frames (3,12,13). In contrast, human SEF lacks a clear topography ( Fig. S1; refs. 14-16). Macaque SEF also lacks a clear topography (17,18), although macaque SEF neurons have been shown to represent space in gaze-centered as...

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Section: Discussionsupporting

confidence: 86%

“…S1; refs. [14][15][16]. Macaque SEF also lacks a clear topography (17,18), although macaque SEF neurons have been shown to represent space in gaze-centered as well as head-, body-, and objectcentered reference frames (9,19).…”

mentioning

confidence: 99%

Functional and structural architecture of the human dorsal frontoparietal attention network

Szczepanski

Pinsk

Douglas³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

190

118

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“…Future work will need to differentiate between these various possibilities. Interestingly, a recent study using fMRI repetition suppression found similar evidence for a clear retinotopic representation in all studied regions, but on top of that, weaker evidence for nonretinal coding were also found in the IPS (Van Pelt et al 2010).…”

Section: Discussionmentioning

confidence: 70%

Multiple Reference Frames for Saccadic Planning in the Human Parietal Cortex

Pertzov¹,

Avidan²,

Zohary³

2011

J. Neurosci.

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We apply functional magnetic resonance imaging and multivariate analysis methods to study the coordinate frame in which saccades are represented in the human cortex. Subjects performed a memory-guided saccade task in which equal-amplitude eye movements were executed from several starting points to various directions. Response patterns during the memory period for same-vector saccades were correlated in the frontal eye fields and the intraparietal sulcus (IPS), indicating a retinotopic representation. Interestingly, response patterns in the middle aspect of the IPS were also correlated for saccades made to the same destination point, even when their movement vector was different. Thus, this region also contains information about saccade destination in (at least) a head-centered coordinate frame. This finding may explain behavioral and neuropsychological studies demonstrating that eye movements are also anchored to an egocentric or an allocentric representation of space rather than strictly to the retinal visual input and that parietal cortex is involved in maintaining these representations of space.

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“…The contrast of interest was computed for each unilateral ROI as the sum of the two regressors capturing saccade planning to an updated target presented within the contra-illusion (i.e., the L-illusion for the right hemisphere and the R-illusion for the left hemisphere) minus the sum of the two regressors capturing saccade planning to an updated target within the ipsi-illusion (i.e., the R-illusion for the right hemisphere and the L-illusion for the left hemisphere). Next, to assess whether the BOLD response during the delay was lateralized as a result of the illusion, we computed a contralateral bias C that scales the contrast to the sum of the BOLD response (e.g., Schluppeck et al, 2006;Van Pelt et al, …”

Section: General Linear Model and Regions Of Interestmentioning

confidence: 99%

The Müller-Lyer illusion affects visuomotor updating in the dorsal visual stream

et al. 2015

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Repetition Suppression Dissociates Spatial Frames of Reference in Human Saccade Generation

Cited by 21 publications

References 69 publications

Functional and structural architecture of the human dorsal frontoparietal attention network

Functional and structural architecture of the human dorsal frontoparietal attention network

Multiple Reference Frames for Saccadic Planning in the Human Parietal Cortex

The Müller-Lyer illusion affects visuomotor updating in the dorsal visual stream

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