Repetitive application of caffeine sensitizes caffeine-induced Ca2+ release in bullfrog sympathetic ganglion neurons

Higure, Yoko; Nohmi, Mitsuo

doi:10.1016/s0006-8993(02)03397-8

Cited by 3 publications

(1 citation statement)

References 30 publications

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“…Results have revealed deleterious effects on the nervous system (Nehlig, 1999;Higure and Nohmi, 2002), on the sensitization of DNA to damage (MacPhee and Leyden, 1985;Pons and Muller, 1990), on the delayed entry of cells into mitosis and on other aspects of cell division (La Pena et al, 1981;Hepler and Bonsignore, 1990;Narayanan et al, 1997;Deplanque et al, 2000), on the development of organisms (Sehgal and Simões, 1976;Sehgal et al, 1977;Kawano and Simões, 1987;Fort et al, 1998;Castellanos and Rapoport, 2002;Burdan, 2003), on fertility (Hewavitharanage et al, 1999), and on chromatin structure (Terasaka and Niitsu, 1987), to mention but a few. Caffeine (CAF) also increased the production of chromosomal damage induced by chemicals or ionizing radiation (Timson, 1977;Targa and Rodriguez, 1982).…”

Section: Introductionmentioning

confidence: 99%

Effects of caffeine and used coffee grounds on biological features of Aedes aegypti (Diptera, Culicidae) and their possible use in alternative control

2003

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Caffeine and used coffee grounds completely blocked the development of Aedes aegypti in the early stages, in treatments with the concentrations 1.0 mg/mL and 50 mg/mL, respectively. More advanced stages and even adults were obtained in lower concentrations of both substances, enabling observations to be made of mortality rate, longevity and esterase patterns. The experiments involved treatments using either eggs or 3 rd instar larvae (L3), with or without the addition of fish food. Mortality rates prior to the adult stage and adult longevity were significantly different in the comparisons among treatments, in every kind of experiment, but in those using L3 larvae, their percentages were smaller. Observations of the time of larva and adult onset suggested that developmental time was also delayed in treatments with both substances. The addition of fish food increased significantly the number of adults produced in caffeine 0.2 and in the control, but in used coffee grounds, the opposite effect occurred. Longevity was apparently not affected by the addition of food, except again in coffee grounds, in which it decreased. In an attempt to detect a mechanism involved in the action of caffeine and coffee grounds, esterases (enzymes involved in the detoxification of xenobiotics) were analyzed in polyacrylamide gels of treated 4 th instar larvae (L4). In treatments with both substances, the expression of some carboxylesterases was affected, suggesting that they may be involved in the observed impairment.

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Section: Introductionmentioning

confidence: 99%

Effects of caffeine and used coffee grounds on biological features of Aedes aegypti (Diptera, Culicidae) and their possible use in alternative control

2003

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Can 4-chloro-m-cresol be substituted for caffeine as an activator of calcium oscillation in bullfrog sympathetic ganglion cells?

2006

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Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons

Verkhratsky¹

2005

Physiological Reviews

675

602

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The endoplasmic reticulum (ER) is the largest single intracellular organelle, which is present in all types of nerve cells. The ER is an interconnected, internally continuous system of tubules and cisterns, which extends from the nuclear envelope to axons and presynaptic terminals, as well as to dendrites and dendritic spines. Ca(2+) release channels and Ca(2+) pumps residing in the ER membrane provide for its excitability. Regulated ER Ca(2+) release controls many neuronal functions, from plasmalemmal excitability to synaptic plasticity. Enzymatic cascades dependent on the Ca(2+) concentration in the ER lumen integrate rapid Ca(2+) signaling with long-lasting adaptive responses through modifications in protein synthesis and processing. Disruptions of ER Ca(2+) homeostasis are critically involved in various forms of neuropathology.

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Repetitive application of caffeine sensitizes caffeine-induced Ca2+ release in bullfrog sympathetic ganglion neurons

Cited by 3 publications

References 30 publications

Effects of caffeine and used coffee grounds on biological features of Aedes aegypti (Diptera, Culicidae) and their possible use in alternative control

Effects of caffeine and used coffee grounds on biological features of Aedes aegypti (Diptera, Culicidae) and their possible use in alternative control

Can 4-chloro-m-cresol be substituted for caffeine as an activator of calcium oscillation in bullfrog sympathetic ganglion cells?

Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons

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