Repetitive exposure of mice to strong static magnetic fields in utero does not impair fertility in adulthood but may affect placental weight of offspring

Zaun, Gregor; Zahedi, Yasmin; Maderwald, Stefan; Orzada, Stephan; Pütter, Carolin; Scherag, André; Winterhager, Elke; Ladd, Mark E.; Grümmer, Ruth

doi:10.1002/jmri.24208

Cited by 9 publications

(4 citation statements)

References 42 publications

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“…37 In fact, we also did some short-term behavior tests in combination with some mechanistic studies about the neural system to investigate the transient effects of these high SMF exposure, which will be reported in a separate paper later. Moreover, according to studies investigating the effects of on the skeletal, 38,39 cardiovascular, 40 and reproductive and developmental 41,42 systems, it is possible that other physiological aspects could be affected by ultra-high SMFs, which will need further investigation.…”

Section: Discussionmentioning

confidence: 99%

Safety evaluation of mice exposed to 7.0–33.0 T high‐static magnetic fields

Tian

Yang

et al. 2020

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) of 7 T and higher can provide superior image resolution and capability. Clinical tests have been performed in 9.4 T MRI, and 21.1 T small‐bore‐size MRI has also been tested in rodents. Although the safety issue is a prerequisite for their future medical application, there are very few relevant studies for the safety of static magnetic fields (SMFs) of ≧20 T. The aim of this study was to assess the biological effects of 7.0–33.0 T SMFs in healthy adult mice. This was a prospective study, in which 104 healthy adult C57BL/6 mice were divided into control, sham control, and 7.0–33.0 T SMF‐exposed groups.The sham control group and SMF group were handled identically, except for the electric current for producing SMF. A separate control group was placed outside the magnet and their data were used as normal range. After 1 h exposure, all mice were routinely fed for another 2 months while their body weight and food/water consumption were monitored. After 2 months, their complete blood count, blood biochemistry, key organ weight, and histomorphology were examined. All data are normally distributed. Differences between the sham and SMF‐exposed groups were evaluated by unpaired t test. Most indicators did not show statistically significant changes or were still within the normal ranges, with only a few exceptions. For example, mono % in Group 2 (11.1 T) is 6.03 ± 1.43% while the normal range is 6.60–9.90% (p < 0.05). The cholesterol level in 33 T group is 3.38 ± 0.36 mmol/L while the normal range is 2.48–3.29 mmol/L (p < 0.05). The high‐density lipoprotein cholesterol level in 33 T group is 2.54 ± 0.29 mmol/L while the normal reference range is 1.89–2.43 mmol/L (p < 0.01). Exposure to 7.0–33.0 T for 1 h did not have detrimental effects on normal adult mice. Level of Evidence 1 Technical Efficacy Stage 1

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Section: Discussionmentioning

confidence: 99%

Safety evaluation of mice exposed to 7.0–33.0 T high‐static magnetic fields

Tian

Yang

et al. 2020

Magnetic Resonance Imaging

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“…1 Possible adverse effects on reproductive systems by exposure to NIR from MRI system are one of the concerning issues for female employees at MRI facility. Although there are several animal studies whose results showed no adverse effects on fetal developing processes by SMF exposure [5][6][7] or a large-scale epidemiology study which aimed to clarify the influence of fetal MRI examination and showed no harmful effects, 8 these studies do not directly lead to the answers of our concerns. Our present study implemented a questionnaire survey among female employees who worked at MRI facilities and examined the influence of occupational NIR exposure from MRI systems on delivery outcomes to supplement the lack of updated epidemiological evidence.…”

Section: Discussionmentioning

confidence: 84%

Survey of Delivery Outcomes for Employees at MR Imaging Facilities in Japan Based on Information Recorded in the Maternal and Child Health Handbook

Yamaguchi-Sekino

Kojimahara²

2024

magn reson med sci

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“…For example, Bekhite et al [2016] exposed pregnant mice to homogeneous 1 or 10 mT SMFs generated by electromagnets for 20 days and found that only 10 mT treatment caused fetal liver, kidney, and lung tissue damage, and affected eye development, but not the 1 mT treatment group. Zaun et al [2014] placed pregnant mice at the entrance and center of 1.5 and 7 T MRI devices, which provide inhomogeneous and homogeneous SMFs, respectively. There were no abnormalities in sperm morphology or density in all groups, though the sperm motility of offspring exposed to the entrance of 1.5 T MRI (inhomogeneous field) was decreased, but not the other groups (the center of 1.5 or 7 T).…”

Section: Factors That Contribute To the Differential Effects On Repro...mentioning

confidence: 99%

“…Most studies reported absence of SMF effects on sperm, or observed sperm alignment changes. However, there are also a few studies that reported changes [Tablado et al, 1996] or negative effects [Tablado et al, 1998;Tablado et al, 2000;Monfared et al, 2009;Zaun et al, 2014]. Moreover, most studies that showed negative effects were generated by inhomogeneous SMFs [Tablado et al, 1998[Tablado et al, , 2000Monfared et al, 2009;Zaun et al, 2014].…”

Section: The Effects Of Smfs On Male Spermmentioning

confidence: 99%

Effects of Moderate to High Static Magnetic Fields on Reproduction

Chen

Wang

et al. 2022

Bioelectromagnetics

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With the wide application of magnetic resonance imaging in hospitals and permanent magnets in household items, people have increased exposure to various types of static magnetic fields (SMFs) with moderate and high intensities, which has caused a considerable amount of public concern. Studies have shown that some aspects of gametogenesis and early embryonic development can be significantly affected by SMFs, while others have shown no effects. This review summarizes the experimental results of moderate to high‐intensity SMFs (1 mT–16.7 T) on the reproductive development of different model animals, and we find that the effects of SMFs are variable depending on experimental conditions. In general, the effects of inhomogeneous SMFs seem to be more significant compared to that of homogeneous SMFs, which is likely due to magnetic forces generated by the magnetic field gradient. Moreover, some electromagnetic fields may have induced bioeffects because of nonnegligible gradient and heat effect, which are much reduced in superconducting magnets. We hope this review can provide a starting point for more in‐depth analysis of various SMFs on reproduction, which is indispensable for evaluating the safety and potential applications of SMFs on living organisms in the future. © 2022 Bioelectromagnetics Society.

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Repetitive exposure of mice to strong static magnetic fields in utero does not impair fertility in adulthood but may affect placental weight of offspring

Abstract: Repetitive in utero exposure to strong static magnetic fields does not impair fertility but may have a parental-dependent effect on fetal programming with regard to placental development and fetal growth.

Cited by 9 publications

References 42 publications

Safety evaluation of mice exposed to 7.0–33.0 T high‐static magnetic fields

Safety evaluation of mice exposed to 7.0–33.0 T high‐static magnetic fields

Survey of Delivery Outcomes for Employees at MR Imaging Facilities in Japan Based on Information Recorded in the Maternal and Child Health Handbook

Effects of Moderate to High Static Magnetic Fields on Reproduction

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