Repetitive Magnetic Stimulation for the Management of Peripheral Neuropathic Pain: A Systematic Review

Aamir, Abdullah; Girach, Ayesha; Sarrigiannis, Ptolemaios G.; Hadjivassiliou, Marios; Paladini, Antonela; Varrassi, Giustino; Zis, Panagiotis

doi:10.1007/s12325-020-01231-2

Cited by 26 publications

(24 citation statements)

References 45 publications

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“…Repetitive transcranial magnetic stimulation (rTMS) is a safe and well-tolerated intervention that has been used for the treatment of many forms of neuropathic pain [82,83]. The use of rTMS of the motor cortex for the treatment of CPSP has only been studied in small studies (fewer than 25 subjects in each study) with contradictory results.…”

Section: Magnetic Stimulationmentioning

confidence: 99%

Prevalence and Management Challenges in Central Post-Stroke Neuropathic Pain: A Systematic Review and Meta-analysis

et al. 2020

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Introduction: Central post-stroke pain (CPSP) is defined as the neuropathic pain that arises either acutely or in the chronic phase of a cerebrovascular event and is a result of central lesions of the somatosensory tract. The aim of this systematic review and meta-analysis was to establish the prevalence of CPSP, to describe its characteristics, and to discuss the associated management challenges. Methods: After a systematic Medline search, we identified 69 papers eligible to be included. Results: The pooled prevalence of CPSP in patients with stroke at any location was 11% (95% CI 7-18%), which can increase to more than 50% in the subgroups of patients with medullary or thalamic strokes. CPSP onset coincides with stroke occurrence in 26% of patients (95% CI 18-35%); CPSP manifests within a month since symptom onset in 31% of patients (95% CI 22-42%), and occurs between the first month and the first year in 41% of patients (95% CI 33.9-49.0%). CPSP develops more than 12 months after stroke onset in 5% of patients (95% CI 3-8%). Conclusions: Clinicians should look for any evidence of central neuropathic pain for at least 12 months after stroke. Both pharmacological and non-pharmacological interventions can be used for the management of CPSP. Lamotrigine has the strongest evidence (Level II of evidence, derived from small randomized controlled trials) for being effective in the management of CPSP. Future research should focus on well-designed trials of pharmacological and non-pharmacological interventions aiming to relief CPSP, which is a very common but often neglected pain syndrome.

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Section: Magnetic Stimulationmentioning

confidence: 99%

Prevalence and Management Challenges in Central Post-Stroke Neuropathic Pain: A Systematic Review and Meta-analysis

et al. 2020

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“…Neuromodulation has many strengths: "reversibility, programmability, low risk and specificity" [12]. The benefits of neuromodulation include improved quality of life, relief from pain, and enhanced functional status [13]. All of these correspond to a reduction in overall healthcare needs and utilization of healthcare resources.…”

Section: Introductionmentioning

confidence: 99%

“…In this paper, we will provide detailed analysis and discussion on some of the most common neuromodulation techniques currently utilized to treat chronic, refractory pain: transcranial direct current stimulation (tDCS), transcutaneous electrical nerve stimulation (TENS), repetitive transcranial magnetic stimulation (rTMS), pulsed electromagnetic field (PEMF), and peripheral nerve stimulation (PNS). Transcranial direct current stimulation Overview tDCS is a non-invasive cortico-neuromodulatory stimulation treatment that utilizes a constant lowintensity electrical current to modulate neuronal activity [13][14][15]. By applying anodal or cathodal currents via electrodes positioned on the scalp, clinicians can target regional areas of the brain and produce subthreshold excitatory or inhibitory effects on the resting membrane potential based on the polarity of the electrode and can enhance or weaken synaptic connections [16].…”

Section: Introductionmentioning

confidence: 99%

Neuromodulation for Pain Management in the Inpatient Setting: A Narrative Review

Abd‐Elsayed

Tang

Karri

et al. 2021

Cureus

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“…Non-pharmacological interventions have been proposed to be used in PNP, mostly as adjuvant to pharmacological treatments [16][17][18]. The aim of this systematic review was to evaluate the currently available evidence, derived from randomized controlled trials (RCTs) that assess non-pharmacological interventions for the treatment of peripheral neuropathic pain.…”

Section: Introductionmentioning

confidence: 99%

Non-Pharmacological Management of Painful Peripheral Neuropathies: A Systematic Review

et al. 2020

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Repetitive Magnetic Stimulation for the Management of Peripheral Neuropathic Pain: A Systematic Review

Cited by 26 publications

References 45 publications

Prevalence and Management Challenges in Central Post-Stroke Neuropathic Pain: A Systematic Review and Meta-analysis

Prevalence and Management Challenges in Central Post-Stroke Neuropathic Pain: A Systematic Review and Meta-analysis

Neuromodulation for Pain Management in the Inpatient Setting: A Narrative Review

Non-Pharmacological Management of Painful Peripheral Neuropathies: A Systematic Review

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