Repetitive non-typhoidal Salmonella exposure is an environmental risk factor for colon cancer and tumor growth

Colon cancer and cell transformation by clinicalSalmonellastrains are associated with bacterial virulence and intracellular fitness

“…Besides, the patients with SL - tumors may have been exposed to NTS while developing no or mild symptoms. Those most commonly mild and unreported infections are sufficient to promote colon cancer (van Elsland et al, 2022) but are not registered as patients with an NTS infection. Despite these intrinsic limits, the outcomes of our pathology analyses are aligned with earlier research showing that colon tumors of patients with a history of NTS infection were mostly of low grade (Mughini-Gras et al, 2018).…”

“…We previously reported that Salmonella -induced cell transformation required at least two host pre-transforming steps before infection, in particular the inactivation of the p53 pathway (by knocking out Arf) and the overexpression of the proto-oncogene c-MYC (Scanu et al, 2015). We thus performed an in cellulo characterization of the 60 clinical strains in mouse embryonic fibroblasts (MEF) overexpressing c-MYC and Arf -deficient, a model cell line that allows monitoring transformation with classical anchorage-independent colony-forming assays (Scanu et al, 2015; van Elsland et al, 2022; Stévenin and Neefjes, 2023). We normalized the results to the transformation efficiency of the lab strain S .…”

“…In the last decade, evidence provided by us and others support that NTS infections increase the risk of colon cancer development (Scanu et al, 2015; Mughini-Gras et al, 2018; Zha et al, 2019; van Elsland et al, 2022). To thrive within its host cell, Salmonella hijacks many intracellular signaling pathways (Galan, 2021), some of which may result in host cell transformation (Scanu et al, 2015; Lu et al, 2016).…”

Microbiome and Diet in Colon Cancer Development and Treatment

“…Bacterial pathogens, such as Helicobacter pylori , E. coli psk , and Salmonella , are known to increase the risk of gastrointestinal cancers, as reviewed in recent articles 96,97 . Systemic Salmonella typhi infections are linked to gallbladder cancer, whereas nontyphoidal Salmonella infections are associated with colon cancer 98 . Fungal component of the intestinal microbiome is also altered in CRC.…”

“…96,97 Systemic Salmonella typhi infections are linked to gallbladder cancer, whereas nontyphoidal Salmonella infections are associated with colon cancer. 98 Fungal component of the intestinal microbiome is also altered in CRC. In fact, an abundance of a specific fungal genus actually promotes the disease.…”