Repetitive Thoughts and Behavior in Pervasive Developmental Disorders

McDougle, Christopher J.

doi:10.1007/978-1-4615-5369-4_13

Cited by 50 publications

(54 citation statements)

References 51 publications

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“…In the author's opinion, the sub-threshold OC symptoms detected in our AS sample might be read as the sign of a phenomenological and possibly neurobiological overlap between ASD and OCD according to the concept of a broader spectrum of OC-related disorders, in line with previous bibliography [4]. This model seems sustained by some evidence derived from the association between ASD and OCD in family studies [1,14] and by some findings from clinical trials of a positive pharmacologic treatment response to SRIs in ASD [15,24,25].…”

Section: Resultssupporting

confidence: 81%

“…Higher prevalence of autistic traits has been found in OCD samples both in adults [5,6] and children [16], and some evidence suggests that treatments effective for OCD may be effective for repetitive thoughts and behaviours in ASD as well [15,19,24,25]. Also, family studies have reported an association between restrictive or repetitive behaviours in probands with autism and obsessive-compulsive features in parents both in multiplex [14] and sporadic autism families [1].…”

Section: Introductionmentioning

confidence: 99%

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Obsessive–compulsive traits in children and adolescents with Asperger syndrome

Ruta

Mugno

D'Arrigo

et al. 2009

Eur Child Adolesc Psychiatry

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The objective of this study is to examine the occurrence and characteristic features of obsessive-compulsive behaviours in children and adolescents with Asperger syndrome (AS), with respect to a matched obsessive compulsive disorder group (OCD) and a typically developing control group (CG). For this purpose, 60 subjects (20 OCD; 18 AS; 22 CG), aged 8-15 years, matched for age, gender and IQ were compared. AS and OCD patients were diagnosed according to the DSM-IV-TR criteria. The Autism Diagnostic Interview-Revised and the Autism Diagnostic Observation Schedule were used to assist in the AS diagnosis; the WISC-R was administered to assess IQ. Obsessive and compulsive symptoms were evaluated by using the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS). None of the AS children received a formal diagnosis of OCD. The AS group presented significantly higher frequencies of Hoarding obsessions and Repeating, Ordering and Hoarding compulsions compared to CG. The OCD group, in turn, reported significantly higher frequencies of Contamination and Aggressive obsessions and Checking compulsions compared to both the AS group and CG. As expected, the OCD group displayed a higher severity of symptoms (Moderate level of severity) than did the AS group (Mild level of severity). Finally, in our sample, neither the OCD group nor the AS group demonstrated a completely full awareness of the intrusive, unreasonable and distressing nature of symptoms, and the level of insight did not differ between the OCD group and CG, although an absence of insight was observed in the AS group. Children with AS showed higher frequencies of obsessive and compulsive symptoms than did typically developing children, and these features seem to cluster around Hoarding behaviours. Additionally, different patterns of symptoms emerged between the OCD and AS groups. Finally, in our sample, the level of insight was poor in both the OCD and the AS children. Further research should be conducted to better understand the characteristics of repetitive thoughts and behaviours in autism spectrum disorders, and to clarify the underlying neurobiological basis of these symptoms.

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Section: Resultssupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Obsessive–compulsive traits in children and adolescents with Asperger syndrome

Ruta

Mugno

D'Arrigo

et al. 2009

Eur Child Adolesc Psychiatry

View full text Add to dashboard Cite

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“…Significant improvements in repetitive thoughts and behavior, maladaptive behavior, aggression, social relatedness and language usage were reported. In contrast to this adult trial of fluvoxamine, a subsequent trial in children and adolescents with ASD conducted by the same group found poor response to fluvoxamine, only one of 18 responded, while 14 had adverse effects (McDougle et al, 2000). However, subjects were started on a relatively high dose of 50 mg, which may have contributed to early activation symptoms that limited tolerability.…”

Section: Introductionmentioning

confidence: 77%

A Placebo Controlled Crossover Trial of Liquid Fluoxetine on Repetitive Behaviors in Childhood and Adolescent Autism

Hollander

Phillips

Chaplin

et al. 2004

Neuropsychopharmacol

353

214

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Repetitive behaviors are a core symptom domain in autism that has been linked to alterations in the serotonin system. While the selective serotonin-receptive inhibitor fluvoxamine has been shown to be effective in adults with autism, as yet no published placebo controlled trials with these agents document safety and efficacy in children with autism. This study examines the selective serotonin reuptake inhibitor liquid fluoxetine in the treatment of repetitive behaviors in childhood and adolescent autism spectrum disorders (ASDs). In total, 45 child or adolescent patients with ASD were randomized into two acute 8-week phases in a double-blind placebocontrolled crossover study of liquid fluoxetine. Study design included two randomized 8-week fluoxetine and placebo phases separated by a 4-week washout phase. Outcome measures included measures of repetitive behaviors and global improvement. Low-dose liquid fluoxetine (mean final dose: 9.974.35 mg/day) was superior to placebo in the treatment of repetitive behaviors by CY-BOCS compulsion scale. The effect size was in the moderate to large range, and the doses used were low. Liquid fluoxetine was only slightly, and not significantly, superior to placebo on CGI autism score partially due to a phase order effect. However, fluoxetine was marginally superior to placebo on a composite measure of global effectiveness. Liquid fluoxetine did not significantly differ from placebo on treatment emergent side effects. Liquid fluoxetine in low doses is more effective than placebo in the treatment of repetitive behaviors in childhood autism. Limitations include small sample size and the crossover design of the study. Further replication and long-term maintenance trials are needed.

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“…122 Two controlled studies with adult autistic patients (one with fluoxetine and one with fluvoxamine) showed improvement of repetitive behaviors, compared to placebo. 123 Akathisia or excessive activation seems to be a relatively frequent dose-dependent side effect.…”

Section: Pharmacotherapymentioning

confidence: 99%

Autismo e doenças invasivas de desenvolvimento

Gadia¹,

Tuchman²,

Rotta³

2004

J. Pediatr. (Rio J.)

121

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Objective: To review the current knowledge on neurobiological aspects of autism and pervasive developmental disorders, as well as to provide pediatricians with up to date information on diagnosis and treatment of autism. Sources of data: Review of MEDLINE and Internet.Summary of the findings: Autism is the 3rd developmental disorder, with an incidence of 40 to 130/100,000 individuals. Diagnosis is based on clinical findings, following DSM IV criteria. Neuroimaging, investigation of fetal neurological status, and genetic investigation contribute towards a better understanding of the neurobiology of autism. Conclusion:Pediatricians are the first health professional to come in contact with patients with autism. Thus, they should be able to diagnose and to coordinate the multidisciplinary treatment of these patients.J Pediatr (Rio J). 2004;80(2 Suppl):S83-S94: Autism, child behavior, child development.

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Repetitive Thoughts and Behavior in Pervasive Developmental Disorders

Cited by 50 publications

References 51 publications

Obsessive–compulsive traits in children and adolescents with Asperger syndrome

Obsessive–compulsive traits in children and adolescents with Asperger syndrome

A Placebo Controlled Crossover Trial of Liquid Fluoxetine on Repetitive Behaviors in Childhood and Adolescent Autism

Autismo e doenças invasivas de desenvolvimento

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